Développement d'algorithmes pour la fonction NCTR - Application des calculs parallèles sur les processeurs GPU.

Le thème principal de cette thèse est l'étude d'algorithmes de reconnaissance de cibles non coopératives (NCTR). Il s'agit de faire de la reconnaissance au sein de la classe "chasseur" en utilisant le profil distance. Nous proposons l'étude de quatre algorithmes : un basé sur l'algorithme des KPPV, un sur les méthodes probabilistes et deux sur la logique floue. Une contrainte majeure des algorithmes NCTR est le contrôle du taux d'erreur tout en maximisant le taux de succès. Nous avons pu montrer que les deux premiers algorithmes ne permettait pas de respecter cette contrainte. Nous avons en revanche proposé deux algorithmes basés sur la logique floue qui permettent de respecter cette contrainte. Ceci se fait au détriment du taux de succès (notamment sur les données réelles) pour le premier des deux algorithmes. Cependant la deuxième version de l'algorithme a permis d'augmenter considérablement le taux de succès tout en gardant le contrôle du taux d'erreur. Le principe de cet algorithme est de caractériser, case distance par case distance, l'appartenance à une classe en introduisant notamment des données acquises en chambre sourde. Nous avons également proposé une procédure permettant d'adapter les données acquises en chambre sourde pour une classe donnée à d'autres classes de cibles. La deuxième contrainte forte des algorithmes NCTR est la contrainte du temps réel. Une étude poussée d'une parallélisation de l'algorithme basé sur les KPPV a été réalisée en début de thèse. Cette étude a permis de faire ressortir les points à prendre en compte lors d'une parallélisation sur GPU d'algorithmes NCTR. Les conclusions tirées de cette étude permettront par la suite de paralléliser de manière efficace sur GPU les futurs algorithmes NCTR et notamment ceux proposés dans le cadre de cette thèse.The main subject of this thesis is the study of algorithms for non-cooperative targets recognition (NCTR). The purpose is to make recognition within "fighter" class using range profile. The study of four algorithms is proposed : one based on the KNN algorithm, one on probabilistic methods and two on fuzzy logic. A major constraint of NCTR algorithms is to control the error rate while maximizing the success rate. We have shown that the two first algorithms are not sufficient to fulfill this requirement. On the other hand, two algorithms based on fuzzy logic have been proposed and meet this requirement. Compliance with this condition is made at the expense of success rate (in particular on real data) for the first of the two algorithms based on fuzzy-logic. However, a second version of the algorithm has greatly increased the success rate while keeping control of the error rate. The principle of this algorithm is to make classification range bin by range bin, with the introduction of data acquired in an anechoic chamber. We also proposed a procedure for adapting the data acquired in an anechoic chamber for a class to another class of targets. The second major constraint algorithms NCTR is the real time constraint. An advanced study of a parallelization on GPU of the algorithm based on KNN was conducted at the beginning of the thesis. This study has helped to identify key points of a parallelization on GPU of NCTR algorithms. Findings from this study will be used to parallelize efficiently on GPU future NCTR algorithms, including those proposed in the thesis.PARIS11-SCD-Bib. électronique (914719901) / SudocSudocFranceF

The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation

SummaryAlthough DNA damaging agents have revolutionized chemotherapy against solid tumors, a narrow therapeutic window combined with severe side effects has limited their broader use. Here we show that RAD001 (everolimus), a rapamycin derivative, dramatically enhances cisplatin-induced apoptosis in wild-type p53, but not mutant p53 tumor cells. The use of isogenic tumor cell lines expressing either wild-type mTOR cDNA or a mutant that does not bind RAD001 demonstrates that the effects of RAD001 are through inhibition of mTOR function. We further show that RAD001 sensitizes cells to cisplatin by inhibiting p53-induced p21 expression. Unexpectedly, this effect is attributed to a small but significant inhibition of p21 translation combined with its short half-life. These findings provide the molecular rationale for combining DNA damaging agents with RAD001, showing that a general effect on a major anabolic process may dramatically enhance the efficacy of an established drug protocol in the treatment of cancer patients with solid tumors

The effects of laryngeal mask airway passage simulation training on the acquisition of undergraduate clinical skills: a randomised controlled trial

Background\ud Effective use of the laryngeal mask airway (LMA) requires learning proper insertion technique in normal patients undergoing routine surgical procedures. However, there is a move towards simulation training for learning practical clinical skills, such as LMA placement. The evidence linking different amounts of mannequin simulation training to the undergraduate clinical skill of LMA placement in real patients is limited. The purpose of this study was to compare the effectiveness in vivo of two LMA placement simulation courses of different durations. \ud \ud Methods\ud Medical students (n = 126) enrolled in a randomised controlled trial. Seventy-eight of these students completed the trial. The control group (n = 38) received brief mannequin training while the intervention group (n = 40) received additional more intensive mannequin training as part of which they repeated LMA insertion until they were proficient. The anaesthetists supervising LMA placements in real patients rated the participants' performance on assessment forms. Participants completed a self-assessment questionnaire. \ud \ud Results\ud Additional mannequin training was not associated with improved performance (37% of intervention participants received an overall placement rating of > 3/5 on their first patient compared to 48% of the control group, $X^2$ = 0.81, p = 0.37). The agreement between the participants and their instructors in terms of LMA placement success rates was poor to fair. Participants reported that mannequins were poor at mimicking reality. \ud \ud Conclusions\ud The results suggest that the value of extended mannequin simulation training in the case of LMA placement is limited. Educators considering simulation for the training of practical skills should reflect on the extent to which the in vitro simulation mimics the skill required and the degree of difficulty of the procedure. \ud \u