1,712 research outputs found
Attributions for Success and Failure in Mathematics: A Comparative Study of Catholic and Public School Students
The documented higher performance of minority students in Catholic versus public schools raises questions about motivational factors that may underlie the impact of parochial education. This study examines attributions for success and failure and their relationship to mathematics achievement in a sample of African American, Latino, and Caucasian fifth- and sixth-grade public and Catholic school students. Results showed that relative to their public school peers minority students in Catholic schools endorsed attributions that were more adaptive for learning. Specifically: 1) Latino and African American Catholic school students were less likely to attribute success in mathematics to external factors, 2) Latino Catholic school students were more likely to attribute success to ability, and 3) African American Catholic school students were less likely to attribute failure to external factors. Further, for Latino students, Catholic but not public school membership was positively associated with mathematics achievement. Results are discussed in the context of school culture
Proprioceptive feedback facilitates motor imagery-related operant learning of sensorimotor β-band modulation
Motor imagery (MI) activates the sensorimotor system independent of actual movements and might be facilitated by neurofeedback. Knowledge on the interaction between feedback modality and the involved frequency bands during MI-related brain self-regulation is still scarce. Previous studies compared the cortical activity during the MI task with concurrent feedback (MI with feedback condition) to cortical activity during the relaxation task where no feedback was provided (relaxation without feedback condition). The observed differences might, therefore, be related to either the task or the feedback. A proper comparison would necessitate studying a relaxation condition with feedback and a MI task condition without feedback as well. Right-handed healthy subjects performed two tasks, i.e., MI and relaxation, in alternating order. Each of the tasks (MI vs. relaxation) was studied with and without feedback. The respective event-driven oscillatory activity, i.e., sensorimotor desynchronization (during MI) or synchronization (during relaxation), was rewarded with contingent feedback. Importantly, feedback onset was delayed to study the task-related cortical activity in the absence of feedback provision during the delay period. The reward modality was alternated every 15 trials between proprioceptive and visual feedback. Proprioceptive input was superior to visual input to increase the range of task-related spectral perturbations in the α- and β-band, and was necessary to consistently achieve MI-related sensorimotor desynchronization (ERD) significantly below baseline. These effects occurred in task periods without feedback as well. The increased accuracy and duration of learned brain self-regulation achieved in the proprioceptive condition was specific to the β-band. MI-related operant learning of brain self-regulation is facilitated by proprioceptive feedback and mediated in the sensorimotor β-band
A Scoping Review of Digital Gaming Research Involving Older Adults Aged 85 and Older
Background: Interest in the use of digital game technologies by older adults is growing across disciplines from health and gerontology to computer science and game studies. The objective of this scoping review was to examine research evidence involving the oldest old (persons 85 years of age or greater) and digital game technology.
Materials and Methods: PubMed, CINHAL, and Scopus were searched, and 46 articles were included in this review.
Results: Results highlighted that 60 percent of articles were published in gerontological journals, whereas only 8.7 percent were published in computer science journals. No studies focused directly on the oldest old population. Few studies included sample sizes greater than 100 participants. Seven primary and 34 secondary themes were identified, of which Hardware Technology and Assessment were the most common.
Conclusions: Existing evidence demonstrates the paucity of studies engaging older adults 85 years of age and above regarding the use of digital gaming and highlights a new understudied cohort for further research focus. Recommendations for future research include intentional recruitment and proportionate representation of participants ≥85 years of age, large sample sizes, and explicit mention of specific numbers of participants ≥85 years of age, which are necessary to advance knowledge in this area. Integrating a rigorous and robust mixed-methods approach including theoretical perspectives would lend itself to further in-depth understanding and knowledge generation in this field
The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells
Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including neuroendocrine tumors (NETs). However, no preclinical data about the effects of RAD001 on NET cells have been published. In this study, we aimed to evaluate the effects of RAD001 on BON cells, a human pancreatic NET cell line that exhibits constitutively activated PI(3) K/Akt/mTOR signaling. Methods: BON cells were treated with different concentrations of RAD001 to analyze its effect on cell growth using proliferation assays. Apoptosis was examined by Western blot analysis of caspase-3/PARP cleavage and by FACS analysis of DNA fragmentation. Results: RAD001 potently inhibited BON cell growth in a dose-dependent manner which was dependent on the serum concentration in the medium. RAD001-induced growth inhibition involved G0/G1-phase arrest as well as induction of apoptosis. Conclusion: In summary, our data demonstrate antiproliferative and apoptotic effects of RAD001 in NET cells in vitro supporting its clinical use in current phase II trials in NET patients. Copyright (c) 2007 S. Karger AG, Basel
Pulse-shape discrimination and energy resolution of a liquid-argon scintillator with xenon doping
Liquid-argon scintillation detectors are used in fundamental physics
experiments and are being considered for security applications. Previous
studies have suggested that the addition of small amounts of xenon dopant
improves performance in light or signal yield, energy resolution, and particle
discrimination. In this study, we investigate the detector response for xenon
dopant concentrations from 9 +/- 5 ppm to 1100 +/- 500 ppm xenon (by weight) in
6 steps. The 3.14-liter detector uses tetraphenyl butadiene (TPB) wavelength
shifter with dual photomultiplier tubes and is operated in single-phase mode.
Gamma-ray-interaction signal yield of 4.0 +/- 0.1 photoelectrons/keV improved
to 5.0 +/- 0.1 photoelectrons/keV with dopant. Energy resolution at 662 keV
improved from (4.4 +/- 0.2)% ({\sigma}) to (3.5 +/- 0.2)% ({\sigma}) with
dopant. Pulse-shape discrimination performance degraded greatly at the first
addition of dopant, slightly improved with additional additions, then rapidly
improved near the end of our dopant range, with performance becoming slightly
better than pure argon at the highest tested dopant concentration. Some
evidence of reduced neutron scintillation efficiency with increasing dopant
concentration was observed. Finally, the waveform shape outside the TPB region
is discussed, suggesting that the contribution to the waveform from
xenon-produced light is primarily in the last portion of the slow component
A methodology for the capture and analysis of hybrid data: a case study of program debugging
No description supplie
Expression of a truncated form of hHb1 hair keratin in human breast carcinomas.
Human hHb1 belongs to the type II hard keratin family and is physiologically expressed in hair shafts. In the present study, using specific 3' and 5' probes for hHb1, we established that breast carcinomas ectopically express a hHb1 5'-truncated mRNA, and that this transcript is restricted to malignant epithelial cells. Furthermore, an in vitro study indicated that it could be translated. We concluded that, in breast carcinomas, expression of truncated hHb1 is related to epithelial cell transformation. Because the hHb1 gene maps to 12q11-q13, a chromosome region known to present several breakpoints in solid tumours, we propose that the hHb1 gene might represent a target for such alterations
CARDigues: an integrated tool for levee system diagnosis and assessment
In December 2007, a French decree related to hydraulic structures (levees and dams) has introduced for owners the necessity to produce a hazard study for each levee system. On the river Loire, three major class A* state levee systems are present and protect three main urban areas, Orléans, Tours and Authion representing some 240 000 inhabitants. Around 40 class B* and C* levee systems are also present on the river Loire and its tributaries representing 600 km of levees and requiring such hazard studies. In order to have a homogenous method to do these specific risk assessment studies on river Loire levees, a new model named CARDigues (for Levee Breach Hazard Calculation) was developed in a partnership with DREAL Centre-Val de Loire, Cerema and Irstea. This model enables to approach the probability of failure on every levee sections and to integrate and cross different “stability” parameters (topography, embedded structures, geology), hydraulic solicitations and observations from visual inspections or instrumentation results considered as disorders (seepage, burrowing animals, vegetation, pipes, etc.). This model and integrated tool CARDigues enables to check for each levee section, the probability of appearance and rupture of five breaching scenarios initiated by: overflowing, internal erosion, slope instability, external erosion and uplift. It has been recently updated and has been applied on several levee systems by different contractors. The article presents the CARDigues model (V28.00) with examples on river Loire and how it is currently used for a relevant and global levee system diagnosis and assessment. Levee reinforcement or improvement management is also a perspective of applications for this model CARDigues. (* levee classes are function of levee height and protected population
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