Computed tomography markers of liver steatosis in offspring of long-lived siblings and control subjects.

<p>Results are from linear mixed model and logistics regression analysis, correcting for age and gender (model 1) and additionally for smoking, body mass index, alcohol use in g/day, and number of hepatotoxic medications (model 2).</p>†<p>LS ratio were available in 131 offspring and 116 controls.</p><p>NAFLD: moderate-to-severe non-alcoholic fatty liver disease, L/S ratio: liver/spleen ratio, 95% CI: 95% confidence interval, HU: hounsfield units.</p

Nonfasting liver enzymes and triglycerides in offspring of long-lived siblings and control subjects.

<p>Results are from linear mixed models, correcting for age, gender, and correlation of sibling relationship (model 1) and additionally for smoking, body mass index, alcohol use in g/day and number of hepatotoxic medications (model 2). Models were fitted for natural log-transformed values of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyltransferase (GGT), and LnTriglycerides. Geometric means (95% confidence interval) are reported for transformed variables.</p

Subject demographics.

<p>Values are means (SE, standard error or 95% CI, confidence interval) or numbers (%). P values are from student’s t-test (^†), Pearson chi-square test (^‡), and from linear mixed model analysis, correcting for age, gender, BMI, and correlation of sibling relationship (^a). Models were fitted for natural log-transformed values for insulin. For transformed variables, data are presented as geometric means with 95% confidence intervals.</p><p>Age: age at serum screening, Hypertension: systolic blood pressure ≥130 mmHg and/or diastolic pressure ≥85 mmHg, or administration of antihypertensive medication, COPD: chronic obstructive pulmonary disease, Insulin: nonfasting serum insulin levels, Glucose: nonfasting serum glucose levels.</p

Association between liver biochemical test parameters and serum glucose.

<p>Tertiles of plasma LnALT, LnAST, LnGGT and serum LnTriglyceride (TG) (mmol/L) in association with nonfasting serum levels (mmol/L) of glucose. Asterisks (*p<0.05, **p<0.01, ***p<0.001) represents significant difference between groups using linear regression analysis, correcting for relation to sibling relationship, age, gender, smoking, alcohol use in g/day, and number of hepatotoxic medication. NS: not significant.</p