Pulmonary Lymphangiomyomatosis in Bourneville’s Tuberous Sclerosis: Case Report

Lymphangiomyomatosisis a rare disease characterized by a proliferation of abnormal smooth muscle cells responsible for infiltration with the destruction of tissue architecture and genesis of cystic lung and lymphatic lesions. In addition to lung damage, Bourneville’s tuberous sclerosis (BTS) also affects the skin, brain, retina, kidneys, and, less frequently, the heart and bone. We report the case of a young patient with bilateral pneumothorax revealing pulmonary lymphangiomyomatosis in the context of Bourneville’stuberoussclerosis BTS

The predictive capacity of uterine artery Doppler for preterm birth—A cohort study

Funding Information NHMRC Practitioner Fellowship. Grant Number: GNT1082548Peer reviewedPublisher PD

Study of State Estimation Using Weighted Least Squares Method

Power state estimation constitutes the core of the on-line security analysis function. The challenge number one of a state estimator is to provide the optimal estimates of system state with minimum of measurement data. This paper describes weighted least squares state estimation method and investigates how the efficiency of WLS state estimation changes according to 4 parameters: number of measurements, measurement type, measurement weight and level of noise. Different simulation cases are tested on 3-bus system and IEEE 14-bus system. The results show that accurate estimates of system state can be obtained with minimum of measurement data on condition to choose a good combination of accurate measurements with a minimum of voltage measurements and power injection measurements and these data should be properly distributed throughout the system. For best results, the two factors (weight and noise) must be combined to obtain the best estimation. Indeed, the most accurate measurements (lower level of noise) should have greater weight compared to bad measurements (higher level of noise), specially voltage measurements due to their big impact

Antifungal Activity of Essential Oils from Several Medicinal Plants against Four Postharvest Citrus Pathogens

Antifungal activity of 25 essential oils, distilled from Moroccan medicinal plants, against Penicillium digitatum, Phytophthora citrophthora, Geotrichum citri-aurantii and Botrytis cinerea is reported. Essential oil from Chrysanthemum viscidehirtum at a concentration of 150 ppm (v:v) strongly inhibited in vitro growth of all four fungi. The other 24 oils reduced fungal development less than 69% at a concentration of 250 ppm. C. viscidehirtum essential oil was further tested on citrus fruits (Citrus reticulata cv. Nules) inoculated with P. digitatum, G. citri-aurantii and P. citrophthora (105 conidia ml-1). The antifungal activity of this oil was weak at 250 ppm, but at 2000 ppm the percentage of decayed fruits was very low. The inhibition data were compared to treatments with the synthetic fungicides procymidone, thiabendazole (TBZ), guazatine and propamocarbe HCL at 1000 ppm. GC-Mass spectrum analysis indicated that C. viscidehirtum essential oil contains ß-farnesene, limonene and many oxygenated sesquiterpenes

Chemical Composition and Anticandidal Effect of Three Thymus Species Essential Oils from Southwest of Morocco against the Emerging Nosocomial Fluconazole-Resistant Strains

The purpose of this present work is to study the essential oils composition of three endemic Thymus species from southwest of Morocco: Thymus satureioides Coss., Thymus pallidus Batt. and Thymus leptobotrys Murb., as well as their antifungal activity towards nineteen strains of emerging nosocomial Fluconazole-resistant Candida species. The chemical composition of the essential oils was determined by capillary gas chromatographic-mass spectrometry analysis. The results reveal qualitative and quantitative variation in composition of Thymus species. Seventy-three different compounds, 56 for T. satureioides accounting for 99.97% of the total essential oil, 52 for T. pallidus, accounting for 98.94% of the total essential oil, and 40 for T. leptobotrys accounting for 99.20%, were determined. The results obtained for the anticandidal disc-diffusion assay shows that the 19 strains of Candida species tested were inhibited by the Moroccan Thymus essential oils to a varying degree, with the diameters of the inhibition zone ranging from 49±1.00 to 85±1.15 mm. There were significant differences (p ? 0.05) in the antifungal activities of the essential oils on all species tested who showed larger inhibition zones than the positive control fluconazole and amphotericine B. Candida albicans showed a high sensitivity to essential oils of Thymus pallidus and Thymus leptobotrys compared with essential oil of Thymus satureioides and controls. While non- albicans Candida species showed less sensitivity to essential oils of Thymus pallidus and Thymus leptobotrys and are more sensitive to essential oils of Thymus satureioides than Candida albicans. Interestingly C. krusei, C. dubliniensis and C. glabrata were found to be resistant to conventional antifungal (fluconazole and amphotericine B), while our essential oils tested were able to inhibit the growth of Candida strains resistant to antifungal agents. The value of Minimal inhibitory concentration (MIC) and Minimal Fungicidal Concentration (MFC) of the Thymus essential oils studied ranges from 0.33 mg/mL to 0.91 mg/mL. All the essential oils possessed higher antifungal potential than classical fungicide. Keywords: Thymus species, essential oils, anticandidal activity, Nosocomial fluconazole-resistant strains