1,386 research outputs found
Buckling vs. particle desorption in a particle-covered drop subject to compressive surface stresses: a simulation study
We study via a new simulation method the transition between buckling and particle desorption when a particle-covered drop is compressed.</p
Accuracy Trends and Sources of Forecast Errors in WASDE Balance Sheet Categories for Corn and Soybeans
Marketing,
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation
Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation. Here we show that C1q, but not C4, is expressed in the stroma and vascular endothelium of several human malignant tumours. Compared with wild-type (WT) or C3- or C5-deficient mice, C1q-deficient (C1qa(-/-)) mice bearing a syngeneic B16 melanoma exhibit a slower tumour growth and prolonged survival. This effect is not attributable to differences in the tumour-infiltrating immune cells. Tumours developing in WT mice display early deposition of C1q, higher vascular density and an increase in the number of lung metastases compared with C1qa(-/-) mice. Bone marrow (BM) chimeras between C1qa(-/-) and WT mice identify non-BM-derived cells as the main local source of C1q that can promote cancer cell adhesion, migration and proliferation. Together these findings support a role for locally synthesized C1q in promoting tumour growth
Comparison of contact parameters measured with two different friction rigs for nonlinear dynamic analysis
The accurate measurement of contact interface parameters is of great importance for nonlinear dynamic response computations since there is a lack of predictive capabilities for such input parameters. Several test rigs have been developed at different institutions, and a series of measurements published, but their reliability remains unknown due to a lack of direct comparisons. To somehow address this issue, a Round-Robin test campaign was performed including the high frequency friction rigs of Imperial College London and Politecnico di Torino. Comparable hysteresis loops were recorded on specimen pairs manufactured from the same batch of raw stainless steel, for a wide range of test conditions, including varying normal loads, sliding distances and nominal areas of contact. Measurements from the two rigs were compared to quantify the level of agreement between the two very different experimental setup, showing a reasonably good matching in the results, but also highlighting some differences. Results also demonstrated that loading conditions can strongly affect the contact parameters, and consequently their effect must be included in future nonlinear dynamic simulations for more reliable predictions
Towards biological control strategies for the bronze bug, Thaumastocoris peregrinus, on eucalyptus plantations in South America.
Edição dos abstracts do 24Âș IUFRO World Congress, 2014, Salt Lake City. Sustaining forests, sustaining people: the role of research
Sporadic flat ileal adenocarcinoma: an intriguing challenge in the comprehension of a rare neoplasia and its genesis. Case report and review of literature
Small bowel adenocarcinoma is a rare tumor, with a still not well studied tumorigenesis process, usually presenting in an advanced stage. The clinical diagnosis is often difficult; surgery is the treatment of choice when feasible, while the chemotherapic approach is still not well codified. We describe the case of a 71-yr-old male patient, presenting with an acute right abdomen. At laparotomy the terminal ileum appeared chronically inflamed and thickened. An ileocecal resection with laterolateral
ileocolic anastomosis was performed. The gross appearance resembled an inflammatory bowel disease, but microscopic examination revealed the extensive presence of an infiltrating ileal adenocarcinoma. Literature about small bowel adenocarcinoma has been reviewed for better understanding its pathogenesis
Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance
Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses. The balance between these two opposing effects is critical in the context of transplantation. Here, we report that female mice deficient in C1q (C1qa(â/â)) or C3 (C3(â/â)) reject male syngeneic grafts (HY incompatible) at an accelerated rate compared with WT mice. Intranasal HY peptide administration, which induces tolerance to syngeneic male grafts in WT mice, fails to induce tolerance in C1qa(â/â) or C3(â/â) mice. The rejection of the male grafts correlated with the presence of HY D(b)Uty-specific CD8(+) T cells. Consistent with this, peptide-treated C1qa(â/â) and C3(â/â) female mice rejecting male grafts exhibited more antigen-specific CD8(+)IFN-Îł(+) and CD8(+)IL-10(+) cells compared with WT females. This suggests that accumulation of IFN-Îł- and IL-10-producing T cells may play a key role in mediating the ongoing inflammatory process and graft rejection. Interestingly, within the tolerized male skin grafts of peptide-treated WT mice, IFN-Îł, C1q and C3 mRNA levels were higher compared to control female grafts. These results suggest that C1q and C3 facilitate the induction of intranasal tolerance
A novel control architecture based on behavior trees for an omni-directional mobile robot
Robotic systems are increasingly present in dynamic environments. This paper proposes a hierarchical control structure wherein a behavior tree (BT) is used to improve the flexibility and adaptability of an omni-directional mobile robot for point stabilization. Flexibility and adaptability are crucial at each level of the senseâplanâact loop to implement robust and effective robotic solutions in dynamic environments. The proposed BT combines high-level decision making and continuous execution monitoring while applying non-linear model predictive control (NMPC) for the point stabilization of an omni-directional mobile robot. The proposed control architecture can guide the mobile robot to any configuration within the workspace while satisfying state constraints (e.g., obstacle avoidance) and input constraints (e.g., motor limits). The effectiveness of the controller was validated through a set of realistic simulation scenarios and experiments in a real environment, where an industrial omni-directional mobile robot performed a point stabilization task with obstacle avoidance in a workspace.This work was financed by national funds from the FCT (Foundation for Science and
Technology), I.P., through IDMEC under LAETA, project UIDB\50022\2020. The work of Rodrigo
Bernardo was supported by the PhD Scholarship BD\6841\2020 from the FCT. This work indirectly
received funding from the European Unionâs Horizon 2020 programme under StandICT.eu 2026
(Grant Agreement No. 101091933).info:eu-repo/semantics/publishedVersio
Assessment of hemostasis in dogs with shock after administration of hydroxyethyl starch (130/0.4) or hypertonic saline (7.5%)
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