197 research outputs found
A gyökfogó dokozahexaénsav mint agyvédő = Docosahexaenoic acid (DHA) as a free radical scavenger brain protector
TelĂtetlen zsĂrsavak (PUFA) fontos szerepet játszanak mint antioxidánsok az emberi testben, kĂĽlönös tekintettel az agyban. Lipidek szisztematikus számĂtási vizsgálatait az OTKA támogatás elĹ‘tt már elkezdtĂĽk. A támogatás alatt 4 fĹ‘ tĂ©materĂĽleten Ă©rtĂĽnk el eredmĂ©nyeket: TĂ©ma 1: Molekuláris konformciĂł változások termodinamikai alapjai Egyszerű szerves molekulák, mint kĂĽlönbözĹ‘ szĂ©nhidrogĂ©n származĂ©kok, peptidek, folytonos termodinamikai fĂĽgvĂ©nyeit állĂtottuk elĹ‘ konformáciĂłs mozgások mentĂ©n. TĂ©ma 2: Zsirsavak konformáciĂłs informáciĂł Igazoltuk a PUFA-k flexibilátásbeli hasonlĂłságát a peptidekhez a potenciál felĂĽletek hasonlĂłságával. DHA a legfontosabb kĂ©pviselĹ‘je a PUFA családnak. TĂ©ma 3: Foszfolipidek konformáciĂłs informáciĂłi Az elsĹ‘ kĂ©t tĂ©ma eredmnyeinek felhasználásával egyszerű foszfolipid modelleket konstruáltunk. A kĂ©t zsirsavlánc relativ helyzte, kölcsönhatásai, membránszerű elrendezĹ‘dĂ©s esetĂ©n állt vizsgálataink homlokterĂ©ben. TĂ©ma4 Szabadgyökök reakciĂłi PUFA Ă©s PUFA modellekkel Szabadgyökök Ă©s reakciĂłik PUFA-val lipidek kettĹ‘srĂ©tegeiben biolĂłgiailag nagyon fontos folyamatok. Az E vitamin az egyik leghatĂ©konyabb gyökfogĂł membránokban. A PUFA-kban mindig megtalálhatĂł allil-C-H kötĂ©sek Ă©s kĂĽlönbözĹ‘ tĂpusĂş gyökök reakciĂłinak kiterjedt vizsgálata folyt. | Polyunsaturated fatty acids (PUFA) play an important role as an antioxidant in the whole human body but more specifically in the brain. The overall project had 4 Topics: Topic 1 Fundamental Thermodynamics of Molecular Conformational Changes: Simple organic molecules were investigated in computing continues thermodynamic functions along conformational changes. These included a variety of compounds from hydrocarbons to peptides. Topic 2 Conformational information of fatty acid: Interestingly enough their felxibility was similar to that of peptides as could be judged from the similarity of their conformational potential energy surfaces. Topic 3 Conformational information of phospholipids: The results and experience obtained from the first two topics were used to construct simple phospholipids. The relative orientations of the two fatty acids in a phospholipid had to be studied to see if the nearly parallel arrangement within the lipid bilayer is enforced by nearest neighbour interaction or if such a geometry is an intrinsically stable structure. Topic 4 Free radical reactions with PUFA and PUFA models: Free radicals and their reactions with PUFA within the lipid bilayer are a biologically very important reactions. The generation of free radicals and their transformation as well as their reactions with allylic C-H bonds, which are always present is PUFA, has been studied in details
Synthesis of glutamine and pyroglutamylglutamine derivatives substituted in the carboxamide nitrogen
- …