The New Corporate Governance landscape and its impact on the companies’ future

The world regulatory landscape of the corporate governance (CG) changed substantially in the last six years having an impact on the company’s business operations and ability to attract capital necessary for the economic growth of the company as the quality of CG significantly contributes to the enhancement of investor and shareholder confidence in the company. Therefore, good corporate governance is a key factor in attracting both local and foreign investments, retaining investor confidence in the company and increasing the company’s competitiveness. Corporate governance refers to having the appropriate people, processes, and structures to direct and manage the business and affairs of the company to enhance long-term shareholder value, whilst considering the interests of other stakeholders. Companies that embrace the tenets of good governance, including accountability, transparency, and sustainability, are more likely to engender investor confidence and achieve long-term sustainable business performance. The attention paid to the international dynamics of corporate governance evolution has led, for example, to a focus on sustainability, through the persistence in promoting the long-term success of the company and its contribution to the community at large. Also in recent years, there has been an increased focus on the role of shareholders/investors in listed companies based on the revised EU legal framework of the dedicated Directive. In addition, G20 and OECD CG principals from 2015 and Paris Agreement from 2015 determined a lot of amendments to the CGC of the capital markets worldwide. The authors will present in this research paper the main directions of the mentioned legal provisions and their impact on the CGC analyzed in the seven years and the new directions for changes proposed by the G20 and OCED after the consultations from 2022

GCA AND SCA EFFECTS FOR RAMIFICATION CAPACITY OF TREES IN F1 APPLE SEEDLINGS

The number of branches per tree was analysed on F1 individuals originated in several crosses between apple cultivars with different architectural ideotypes: spur (Starkrimson, Golden spur), semispur (Liberty), weeping (Florina). The number of branches per tree in F1 hybrid apple, in their third year of vegetation, was different in six combinations, depending on the genotype of genitors, respectively on their architectural ideotype. There have been noticed significant differences among the tested cultivars used as genitors, the average of trait on hybrid combination being comprised between 4.28 in Goldenspur x Liberty and 7.14 in Starkrimson x Florina. A small number of branches per seedling were registered in Starkrimson x Goldenspur combination (4.32), where the both genitors are spur ideotypes. The variability of analysed characters was high, with s% between 33.9 at Liberty x Florina and 56.8 at Starkrimson x Liberty. These values suggest that seedlings with very different number of branches are likely to be identified in each combination. The analysis of variance for GCA and SCA has emphasised the fact that, in the studied apple combinations, both effects of general and specific combining ability contributed to the phenotypic expression of number of branches per tree. Goldenspur showed negative value for GCA, thus this could produce descendents with low vigour and number of branches, if they are used as genitors in apple breeding. Based on the values of general combining ability (GCA) and specific combining ability (SCA) selection of genitors can be very efficient for desirable characters of growth in apple breeding

Expression of β-Defensin-1 and 2 in HPV-Induced Epithelial Lesions

α, β, θ defensins represent a family of small antimicrobial peptides expressed predominantly by a series of cells, including neutrophils, monocytes-macrophages and epithelial cells that are involved in defense mechanisms against viral infections. β-defensins are the most widespread in this family being encountered in oral, digestive, urogenital mucosa and cutaneous lesions. β-defensins directly inactivate certain viruses, including the human papillomavirus(HPV) suppressing viral replication by altering target cells. Considering these aspects, we investigated the immunohistochemical expression of β-defensin-1 and 2 in HPV-induced epithelial lesions. For this study, tumoral and normal mucosal tissue fragments were collected from 10 patients aged between 31-60years, with previously confirmed HPV infection, diagnosed clinically and histopathologically with cervical carcinoma. Patients did not receive any chemotherapy or radiotherapy before the biopsy procedure. The tissue fragments were processed by the standard immunohistochemistry technique using anti-β-defensin-1 and 2 antibodies(Bioss Antibodies). The samples examination revealed weak positive(+) membrane, cytoplasmic and nuclear IR for hβD-1 in basal layer of normal cervical mucosa and moderate positive(++) membrane and cytoplasmic IR in squamous epithelium. For dysplastic HPV-associated tissues we highlighted a nuclear moderate positive(++) IR.For hβD-2, IR in basal layer of the normal mucosa was lower(+) compared with dysplastic cells IR and showed a strong expression(+++) at membrane, cytoplasmic and nuclear level in koilocytes of patients with HPV-associated dysplasia. It was also observed a moderate positive (++) IR in basal layer of dysplastic cells of patients without HPV. The obtained results are in agreement with some literature data, which highlighted the fact that hβD-1 and hβD-2 are very important components of the molecular pattern in HPV-induced lesions

Corelattions Between CD31, CD68, MMP-2 and MMP-9 Expression in Allograft Cardiac Rejection – Immunohistochemical Study

Introduction. The cardiac allograft rejections from the post-transplant period are attributable to the acute cellular rejection monitored by multiple endomyocardial biopsies. Compared to this, humoral rejection remains a matter of debate, with multiple therapeutic strategies, poor prognosis, and persisting uncertainty about diagnostic criteria. Acute allograft rejection is associated with significant modifications of the extracellular matrix compartment mainly regulated by matrix metalloproteinases (MMPs). In this context, the aim of this study was to evaluate the expression of MMP-2 and -9 and CD31, CD68 (endothelial and histiocytic markers) and the correlations between them using immunohistochemistry, in patients with cardiac allografts