The influence of resistant force equations and coupling system on long train dynamics simulations

In the simulation of the longitudinal dynamics of long trains, the modeling of the resistant forces and of the coupling system are two essential aspects. The modeling of the resistant forces directly affects the speed reached by each vehicle as well as the in-train forces. A literature review witnesses different laws for the calculation of both ordinary and accidental resistances. One of the objectives of this paper is to evaluate from the numerical point of view the influence of the resistant forces modeling strategy on the simulation outputs, i.e., on the speeds and in-train forces, by comparing different laws for propulsion and curving resistances. For what concerns the connection between the vehicles of the train, it is well known that the connection system is of utmost importance for the safety and running stability of the train. In this paper, the two existing coupling systems, i.e., the European buffer-hook system and the coupler used outside the European continent are first described, both in terms of operation and modelling techniques, and then they are compared on the same simulation scenario. All the simulations are performed on the first scenario of the International benchmark of the longitudinal train dynamic simulators, using the LTDPoliTO code developed by the railway research team from Politecnico di Torino

Use of polyaspartates for the tartaric stabilisation of white and red wines and side effects on wine characteristics

Aim: The stabilising efficacy against tartaric precipitations of polyaspartates-based products (PAs), in particular potassium polyaspartate (KPA), was tested with six different wines (three white and three red). Some side effects on wine characteristics (white wine colour stability, wine turbidity and filterability) were also studied. Results and conclusions: All PAs showed good stabilising efficacy against tartaric precipitations according to the cold test. With the same test, the PAs were stable in wine for 1 year of storage, which was the total duration of the study. The dose of 100 mg/L was sufficient to stabilise the tested wines. No differences in filterability were observed in comparison with MTA (metatartaric acid). The hypothesised protective effect against colour browning in white wines was not observed. Significance and impact of the study: The international wine trade requires stable wines. This paper provides information to support wineries in managing the use of KPA, as little information is available to date in the literature on this stabilising additive

Monolithically integrated DBR waveguidelaser and intensity modulator in erbiumdoped LiNbO3

For the first time, a DBR laser has been integrated with a Mach Zehnder intensity modulator in Er diffusion doped, Z cut LiNbO,, with Ti indiffused waveguides and dry etched Bragg gratings. The monolithically integrated device has a threshold of 54.8mW incident pump power (hp = 1480nm) and emits, in a single longitudinal mode, up to 0.65 mW CW output power at hs = 1561nm. The Mach-Zehnder type intensity modulator has an optical bandwidth > 3GHz

Trends in and predictors of carbapenem consumption across North American hospitals: Results from a multicenter survey by the MAD-ID research network

This Special Issue is dedicated to the late Dr. Charles (Charlie) D. Hufford, former Professor of Pharmacognosy and Associate Dean for Research and Graduate Studies at University of Mississippi [...]

Cytotoxicity of an innovative pressurised cyclic solid–liquid (Pcsl) extract from artemisia annua

Therapeutic treatments with Artemisia annua have a long-established tradition in various diseases due to its antibacterial, antioxidant, antiviral, anti-malaria and anti-cancer effects. However, in relation to the latter, virtually all reports focused on toxic effects of A. annua extracts were obtained mostly through conventional maceration methods. In the present study, an innovative extraction procedure from A. annua, based on pressurised cyclic solid–liquid (PCSL) extraction, resulted in the production of a new phytocomplex with enhanced anti-cancer properties. This extraction procedure generated a pressure gradient due to compressions and following decompressions, allowing to directly perform the extraction without any maceration. The toxic effects of A. annua PCSL extract were tested on different cells, including three cancer cell lines. The results of this study clearly indicate that the exposure of human, murine and canine cancer cells to serial dilutions of PCSL extract resulted in higher toxicity and stronger propensity to induce apoptosis than that detected by subjecting the same cells to Artemisia extracts obtained through canonical extraction by maceration. Collected data suggest that PCSL extract of A. annua could be a promising and economic new therapeutic tool to treat human and animal tumours

Phenolic profile and biological activity of table grapes (Vitis vinifera L.)

Table grapes are largely produced and consumed in the Mediterranean area. Furthermore, in the last years, the commercial interest in table grapes and other non-alcoholic grape products has notably increased worldwide. In addition to the nutritional aspects, polyphenol compounds in fresh grapes could exert positive effects on human health. The aim of this study was the characterization of the phenolic pattern of sixteen grape varieties and the evaluation of the associated antioxidant capacity and anti-inflammatory activity at gastric level. The methods used were: 1) Folin-Cocalteau\u2019s assay for the quantification of total polyphenol content; 2) High-Performance Liquid Chromatography (HPLC) coupled with Diode-Array Detector (DAD) to perform the quantitative analysis of grapes phenolic fraction 3) DPPH (1,1,-diphenil-2-picrylhydrazyl) spectrophotometric assay for the assessment of radical scavenging activity; 4) assessment of IL-8 release from human gastric epithelial cells to evaluate the anti-inflammatory activity of grape extracts. Some grapes, including seedless varieties, showed that the phenolic pattern was highly correlated with the biological activities, and, in particular, with peel and seeds portion. These results suggest that selected grape varieties could represent, also for consumers who do not drink wine, a source of healthy compounds potentially able to counteract oxidative stress and gastric inflammation