IMPROVED DESIGN OF THE ILC BLADE-TUNER FOR LARGE SCALE PRODUCTION

Abstract The ILC superconducting linacs ask for the use of a compact and cost effective tuner design with no interference with the cavity end group area. The integration of the piezo-assisted fast tuning option made the Blade-Tuner, successfully tested at DESY on the superstructures, the most viable candidate to be included into the ILC BCD. In the perspective of large scale production and on the basis of the experience acquired so far, two alternative prototypes have been recently designed and built. They mainly differ for the materials adopted (titanium or stainless steel) and have been optimized to minimize material and construction cost, while fulfilling the reviewed performances required for the high gradient cavity operation up to 35 MV/m or even higher. In this paper we discuss the rationales that brought us to the current solutions, together with a critical comparison of the two systems behavior and cost

Performance analysis of the European X-ray Free Electron Laser 3.9 GHz superconducting cavities

The limits of performance of the European XFEL 3.9 GHz superconducting cavities were investigated. Most cavities exhibited high field Q slope, reaching the breakdown field at approximately $22\text{ }\text{ }\mathrm{MV}/\mathrm{m}$. We hypothesize that this limit is a feature of high frequency cavities and can be explained by a thermal model incorporating field dependent surface resistance. The results obtained from simulations were in good agreement with experimental data obtained at 2 K

GeV-Class two-fold CW linac driven by an arc-compressor

We present a study of an innovative scheme to generate high repetition rate (MHz-class) GeV electron beams by adopting a two-pass two-way acceleration in a super-conducting Linac operated in Continuous Wave (CW) mode. The beam is accelerated twice in the Linac by being re-injected, after the first pass, in opposite direction of propagation. The task of recirculating the electron beam is performed by an arc compressor composed by 14 Double Bend Achromat (DBA). In this paper, we study the main issues of the two-fold acceleration scheme, the electron beam quality parameters preservation (emittance, energy spread), together with the bunch compression performance of the arc compressor, aiming to operate an X-ray Free Electron Laser. The requested power to supply the cryogenic plant and the RF sources is also significantly reduced w.r.t a conventional one-pass SC Linac for the same final energy

First operations of the LNS heavy ions facility

Abstract A heavy ion facility is now available at Laboratorio Nazionale del Sud (LNS) of Catania. It can deliver beams with an energy up to 100 MeV/amu. The facility is based on a 15MV HVEC tandem and a K = 800 superconducting cyclotron as booster. During the last year, the facility came into operation. A 58Ni beam delivered by the tandem has been radially injected in the SC and then has been accelerated and extracted at 30 MeV/amu. In this paper the status of the facility together with the experience gained during the commissioning will be extensively reported

BriXs ultra high fluxinverse compton source based on modified push-pull energy recovery linacs

We present a conceptual design for a compact X-ray Source BriXS (Bright and compact X-ray Source). BriXS, the first stage of the Marix project, is an Inverse Compton Source (ICS) of X-ray based on superconducting cavities technology for the electron beam with energy recirculation and on a laser system in Fabry-Pérot cavity at a repetition rate of 100 MHz, producing 20–180 keV monochromatic X-Rays devoted mainly to medical applications. An energy recovery scheme based on a modified folded push-pull CW-SC twin Energy Recovery Linac (ERL) ensemble allows us to sustain an MW-class beam power with almost one hundred kW active power dissipation/consumption

Sensitivity to Entrectinib Associated with a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

In metastatic colorectal cancer (CRC), actionable genetic lesions represent potential clinical opportunities. NTRK1, 2, and 3 gene rearrangements encode oncogenic fusions of the tropomyosin-receptor kinase (TRK) family of receptor tyrosine kinases in different tumor types. The TPM3-NTRK1 rearrangement is a recurring event in CRC that renders tumors sensitive to TRKA kinase inhibitors in preclinical models. We identified abnormal expression of the TRKA protein in tumor and liver metastases of a CRC patient refractory to standard therapy. Molecular characterization unveiled a novel LMNA-NTRK1 rearrangement within chromosome 1 with oncogenic potential, and the patient was treated with the pan-TRK inhibitor entrectinib, achieving partial response with decrease in hepatic target lesions from 6.8 and 8.2cm in longest diameter to 4.7 and 4.3cm, respectively. To our knowledge, this is the first clinical evidence of efficacy for therapeutic inhibition of TRKA in a solid tumor, illuminating a genomic-driven strategy to identify CRCs reliant on this oncogene to be clinically targeted with entrectinib

Conceptual Design of a Soft X‐ray SASE‐FEL Source

FELs based on SASE are believed to be powerful tools to explore the frontiers of basic sciences, from physics to chemistry to biology. Intense R&D programs have started in the USA and Europe in order to understand the SASE physics and to prove the feasibility of these sources. The allocation of considerable resources in the Italian National Research Plan (PNR) brought about the formation of a CNR‐ENEA‐INFN‐University of Roma "Tor Vergata" study group. A conceptual design study has been developed and possible schemes for linac sources have been investigated, bringing to the SPARX proposal. We report in this paper the results of a preliminary start to end simulation concerning one option we are considering based on an S‐band normal conducting linac with high brightness photoinjector integrated in a RF compressor