4 research outputs found

    Protein-DNA complexes: specificity and DNA readout mechanisms

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    Protein-nucleic acid recognition is essential in a number of cellular processes, in particular, gene regulation, DNA replication and compaction. Studies on the recognition mechanisms show that DNA sequence carries information which is read out by proteins that selectively bind to specific DNA sites. The review is focused on the processes taking place during formation of specific and nonspecific complexes of proteins and DNA. Special attention is paid to direct and indirect mechanisms of sequence-specific recognition. Several examples of protein-nucleic acid complexes are given to illustrate the variety of recognition mechanism

    Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

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