894 research outputs found
A study of possible sea state information in the sample and hold gate statistics for the GEOS-3 satellite altimeter
The statistical variations in the sample gate outputs of the GEOS-3 satellite altimeter were studied for possible sea state information. After examination of a large number of statistical characteristics of the altimeter waveforms, it was found that the best sea predictor for H-1/3 in the range of 0 to 3 meters was the 75th percentile of sample and hold gate number 11
The Notch pathway is a critical regulator of angiogenesis in a skin model of ischemia
WOS: 000355334000001PubMed ID: 25834117The Notch pathway is definitely required for normal vascular development. Although the contribution of Notch in postnatal angiogenesis is the focus of intense investigation, the implication of Notch in reparative neovascularization in the skin remains unexplored. In this study, we investigated Notch changes using a skin model of ischemia. Thirty Sprague-Dawley rats were divided into two groups. In the surgery group (n = 24), a caudally based dorsal skin flap was raised and sutured back into its initial position. In the control group, no surgical procedure was performed. Tissue biopsies were obtained at different time intervals. Tissue specimens were assessed for Delta-like ligand 4 (DLL4) and vascular endothelial growth factor (VEGF) gene expression by real-time polymerase chain reaction (PCR). Immunohistochemical staining was used for detection of DLL4 in tissue materials. Quantitative assessment of skin flap microvasculature was made. Compared with normoperfused tissue, VEGF and DLL4 expressions increased significantly (p < 0.01). Immunohistochemical analysis revealed weak and patchy expression of DLL4 in microvascular endothelial cells of normoperfused tissues. Conversely, DLL4 expression was upregulated in capillary endothelial cells after ischemia. In conclusion, in this study we have shown that the Notch ligand DLL4 is upregulated in skin tissue after ischemia. A deeper understanding of these fundamental principles will aid in the development of new avenues for the treatment of blood vessel-related skin pathologies.Baskent University Research FundBaskent UniversityThis study was approved by Baskent University Ethical Committee for Experimental Research on Animals and supported by Baskent University Research Fund
Transition phenomena in unstably stratified turbulent flows
We study experimentally and theoretically transition phenomena caused by the
external forcing from Rayleigh-Benard convection with the large-scale
circulation (LSC) to the limiting regime of unstably stratified turbulent flow
without LSC whereby the temperature field behaves like a passive scalar. In the
experiments we use the Rayleigh-B\'enard apparatus with an additional source of
turbulence produced by two oscillating grids located nearby the side walls of
the chamber. When the frequency of the grid oscillations is larger than 2 Hz,
the large-scale circulation (LSC) in turbulent convection is destroyed, and the
destruction of the LSC is accompanied by a strong change of the mean
temperature distribution. However, in all regimes of the unstably stratified
turbulent flow the ratio varies slightly (even in the range
of parameters whereby the behaviour of the temperature field is different from
that of the passive scalar). Here are the integral scales of
turbulence along x, y, z directions, T and \theta are the mean and fluctuating
parts of the fluid temperature. At all frequencies of the grid oscillations we
have detected the long-term nonlinear oscillations of the mean temperature. The
theoretical predictions based on the budget equations for turbulent kinetic
energy, turbulent temperature fluctuations and turbulent heat flux, are in
agreement with the experimental results.Comment: 14 pages, 14 figures, REVTEX4-1, revised versio
Correlation effects during liquid infiltration into hydrophobic nanoporous mediums
Correlation effects arising during liquid infiltration into hydrophobic
porous medium are considered. On the basis of these effects a mechanism of
energy absorption at filling porous medium by nonwetting liquid is suggested.
In accordance with this mechanism, the absorption of mechanical energy is a
result expenditure of energy for the formation of menisci in the pores on the
shell of the infinite cluster and expenditure of energy for the formation of
liquid-porous medium interface in the pores belonging to the infinite cluster
of filled pores. It was found that in dependences on the porosity and,
consequently, in dependences on the number of filled pores neighbors, the
thermal effect of filling can be either positive or negative and the cycle of
infiltration-defiltration can be closed with full outflow of liquid. It can
occur under certain relation between percolation properties of porous medium
and the energy characteristics of the liquid-porous medium interface and the
liquid-gas interface. It is shown that a consecutive account of these
correlation effects and percolation properties of the pores space during
infiltration allow to describe all experimental data under discussion
MultiPath TCP: From Theory to Practice
Abstract. The IETF is developing a new transport layer solution, MultiPath TCP (MPTCP), which allows to efficiently exploit several Internet paths between a pair of hosts, while presenting a single TCP connection to the application layer. From an implementation viewpoint, multiplexing flows at the transport layer raises several challenges. We first explain how this major TCP extension affects the Linux TCP/IP stack when considering the establishment of TCP connections and the transmission and reception of data over multiple paths. Then, based on our implementation of MultiPath TCP in the Linux kernel, we explain how such an implementation can be optimized to achieve high performance and report measurements showing the performance of receive buffer tuning and coupled congestion control
Interactions in vivo between the Vif protein of HIV-1 and the precursor (Pr55GAG) of the virion nucleocapsid proteins
The abnormality of viral core structure seen in vif-defective HIV-1 grown in PBMCs has suggested a role for Vif in viral morphogenesis. Using an in vivo mammalian two-hybrid assay, the interaction between Vif and the precursor (Pr55GAG) of the virion nucleocapsid proteins has been analysed. This revealed the amino-terminal (aa 1–22) and central (aa 70–100) regions of Vif to be essential for its interaction with Pr55GAG, but deletion of the carboxy-terminal (aa 158–192) region of the protein had only a minor effect on its interaction. Initial deletion studies carried out on Pr55GAG showed that a 35-amino-acid region of the protein bridging the MA(p17)–CA(p24) junction was essential for its ability to interact with Vif. Site-directed mutagenesis of a conserved tryptophan (Trp21) near the amino terminus of Vif showed it to be important for the interaction with Pr55GAG. By contrast, mutagenesis of the highly conserved YLAL residues forming part of the BC-box motif, shown to be important in Vif promoting degradation of APOBEC3G/3F, had little or no effect on the Vif–Pr55GAG interaction
Reverberation Mapping Results for Five Seyfert 1 Galaxies
We present the results from a detailed analysis of photometric and
spectrophotometric data on five Seyfert 1 galaxies observed as a part of a
recent reverberation mapping program. The data were collected at several
observatories over a 140-day span beginning in 2010 August and ending in 2011
January. We obtained high sampling-rate light curves for Mrk 335, Mrk 1501,
3C120, Mrk 6, and PG2130+099, from which we have measured the time lag between
variations in the 5100 Angstrom continuum and the H-beta broad emission line.
We then used these measurements to calculate the mass of the supermassive black
hole at the center of each of these galaxies. Our new measurements
substantially improve previous measurements of MBH and the size of the broad
line-emitting region for four sources and add a measurement for one new object.
Our new measurements are consistent with photoionization physics regulating the
location of the broad line region in active galactic nuclei.Comment: 45 pages, 5 figures. Accepted for publication in ApJ. For a brief
video explaining the key results of this paper, see
http://www.youtube.com/user/OSUAstronom
Reverberation Mapping of the Seyfert 1 Galaxy NGC 7469
A large reverberation mapping study of the Seyfert 1 galaxy NGC 7469 has
yielded emission-line lags for Hbeta 4861 and He II 4686 and a central black
hole mass measurement of about 10 million solar masses, consistent with
previous measurements. A very low level of variability during the monitoring
campaign precluded meeting our original goal of recovering velocity-delay maps
from the data, but with the new Hbeta measurement, NGC 7469 is no longer an
outlier in the relationship between the size of the Hbeta-emitting broad-line
region and the AGN luminosity. It was necessary to detrend the continuum and
Hbeta and He II 4686 line light curves and those from archival UV data for
different time-series analysis methods to yield consistent results.Comment: 9 Pages, 7 figures, 6 tables. Accepted for publication in The
Astrophysical Journa
Recommended from our members
The uronic acid content of coccolith-associated polysaccharides provides insight into coccolithogenesis and past climate
Unicellular phytoplanktonic algae (coccolithophores) are among the most prolific producers of calcium carbonate on the planet, with a production of ∼1026 coccoliths per year. During their lith formation, coccolithophores mainly employ coccolith-associated polysaccharides (CAPs) for the regulation of crystal nucleation and growth. These macromolecules interact with the intracellular calcifying compartment (coccolith vesicle) through the charged carboxyl groups of their uronic acid residues. Here we report the isolation of CAPs from modern day coccolithophores and their prehistoric predecessors and we demonstrate that their uronic acid content (UAC) offers a species-specific signature. We also show that there is a correlation between the UAC of CAPs and the internal saturation state of the coccolith vesicle that, for most geologically abundant species, is inextricably linked to carbon availability. These findings suggest that the UAC of CAPs reports on the adaptation of coccolithogenesis to environmental changes and can be used for the estimation of past CO2 concentrations
Clinical experience with the Bicarbon heart valve prosthesis
BACGROUND: We have previously reported mid-term results of a study, which ended in January 2000, on the Bicarbon valve. The study concluded that the valve showed excellent clinical results, associated with a low incidence of valve-related complications. In the present study, the same patients were prospectively followed for an additional 5 years. METHODS: Forty-four patients had aortic valve replacement (AVR), 48 had mitral valve replacement (MVR), and 13 had both aortic and mitral valve replacement (DVR). The mean age of the 105 patients was 61.2 ± 11.3 years. The mean follow-up was 6.1 ± 1.9 years with a cumulative follow-up of 616 patient-years. RESULTS: There were 5 early deaths (4.7%: 4 in the AVR group and 1 in the MVR group) and 21 late deaths (3.4%/patient-year: 5 valve related deaths and 16 valve unrelated deaths). Survival at 8 years was 75.2 ± 7.0% in the AVR group, 76.6 ± 6.2% in the MVR group, and 55.4 ± 16.1% in the DVR group. The linearized incidence of thrombo-embolic complications, hemorrhagic complications, and paravalvular leaks in all patients was 0.65 ± 1.48%, 0.81 ± 1.69%, and 0.16 ± 0.54%/patient-year respectively. No other complications were observed. CONCLUSION: The Bicarbon prosthetic heart valve has shown excellent long-term clinical results, associated with a low incidence of valve-related complications
- …