Efficient Access to o-Phenylendiamines and Their Use in the Synthesis of a 1,2-Dialkyl-5-trifluoromethylbenzimidazoles Library Under Microwave Conditions

A quick access toward a 1,2-dialkyl-5-trifluoromethylbenzimidazoles library by a three-step synthesis sequence starting from 1-chloro-2-nitro-4-(trifluoromethyl)benzene is described. The synthesis proceed via o-phenylendiamines eficiently isolated, which also are key synthetic intermediates of another valuable heterocyclic compounds. Likewise, the trifluoromethyl group is part of the obtained benzimidazoles, affording an important structural feature for their possible applications. The advantages of this methodology are the modular lipophilicity of products, easy work-up, up to 83% overall yield, the convenient use of microwave-assisted reactions, and the production of compounds (intermediates and products) of high-added value using cheap reagents and simple protocols.Fil: Vargas Oviedo, Diana. Universidad de los Andes; ColombiaFil: Charris Molina, Andres Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentina. Universidad de los Andes; ColombiaFil: Portilla, Jaime. Universidad de los Andes; Colombi