Proyecto empresarial de "The Coffe Workshop": estrategia de recursos humanos.

The Coffee Workshop is an entrepreneurial firm located in Quito, Ecuador. The company is a gourmet cafeteria that offers to its clients the opportunity to experience the sensation of the coffee with all its senses. It offers an atmosphere where the coffee is the protagonist as much in the decoration as in the culinary art, from the slightest express coffee to the most distinguished gourmet meal. For our special clients we offer comfortable and private rooms with everything needed for their meetings. Our main approach is directed to executives who look for a comfortable atmosphere, safe and that counts with full-featured to carry out their meetings. This company is created by Alejandro Arguello, Mateo Baca, Rafael Borja, Jorge Castro, Nathaly Gutiérrez y Ángel Ricaurte. The project does not only offer a unique concept in the country, but it is also a great business opportunity which recovers all the investment in just 38 months.The Coffee Workshop es una empresa creada en Quito, Ecuador. La empresa es una cafetería gourmet que ofrece a sus clientes la oportunidad de experimentar la sensación del café con todos sus sentidos. En un ambiente donde el café es el protagonista tanto en la decoración como en el arte culinario, desde el más sutil café expreso hasta el más refinado plato gourmet. Para nuestros clientes estrella tenemos confortables y privadas salas de reuniones. Nuestro principal enfoque está dirigido a ejecutivos que buscan un ambiente cómodo, seguro y que cuente con todas las facilidades para llevar a cabo sus reuniones. Esta empresa es forjada por Alejandro Arguello, Mateo Baca, Rafael Borja, Jorge Castro, Nathaly Gutiérrez y Ángel Ricaurte. La empresa no sólo ofrece un concepto único en el país si no que también rentabilidad ya que recuperará el monto invertido en 38 meses

Factores para el logro del éxito en la industria de restaurantes: caso relacionado con restaurantes independientes de la provincia de Pichincha, Ecuador

The following research paper helps understand which are the factors of success for restaurants located in the province of Pichincha in Ecuador. These were based in a previous study done in Texas, United States, in order to understand what helps restaurants be successful. The research was directed to the owners, presidents, managers or administrators of different restaurants with more than 15 years in business in Pichincha, to confirm the aspects that are really important for success. To measure success we took into account the years in the market, the profits margin managed, and the monthly average sales of the different restaurants.El siguiente trabajo busca conocer cuáles son los factores de éxito en restaurantes ubicados en la provincia de Pichincha, Ecuador. Dichos factores se basaron en un estudio realizado anteriormente en Texas, Estados Unidos, con el fin de conocer que llevó a los distintos restaurantes al éxito. La investigación fue dirigida a los propietarios, presidentes, gerentes o administradores de distintos restaurantes con más de 15 años en el negocio, para validar qué factores son los que sí han tenido influencia para llevarlos al éxito. Con el propósito de medir el éxito se tomaron en cuenta los años en el mercado, los márgenes de utilidad manejados y las ventas mensuales promedio de los distintos restaurantes

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality