Hydrogenated pyrrolopyridines. Synthesis and reactivity

This review presents the progress in hydrogenated pyrrolopyridine synthesis and reactivity studies over the last 20 years. The emphasis has been made on the methods of synthesis and reactivity of the tetrahydrogenated derivatives, especially tetrahydropyrrolo [3,2-c]pyridines

NEW OPPORTUNITIES FOR OXYBUTININ APPLICATION AMONG CHILDREN WITH URINATION DISORDERS

The article gives the findings of M-cholinolytic oxybutinin hydrochloride (Driptane) application among children with urination disorders and enuresis caused by the hyperactivity of the urinary bladder. The researchers show efficiency and safety of the intravesical drug injection according to the elaborated methodology, which allowed for the improvement of the treatment results among children with a combined pathology of the upper urinary tracts and marked side effects in the event of the conventional oral therapy.Key words: urination disorders, enuresis, children, oxybutinin hydrochloride, hyperactivity of the urinary bladder

Heterocyclization of oximes of 3,5-dimethyl(1,3,5-trimethyl)-2,6- diphenylpiperid-4-ones and N-benzylpyrrolid-3-ones with acetylene in a superbasic medium

It has been established that on heterocyclization of 3,5-dimethyl-2,6- diphenylpiperid-4-one oxime with acetylene in a superbasic medium migration of the 3a-CH3 group to the anionic nitrogen atom occurs, leading to the formation of 5,7-dimethyl-4,6-diphenyl-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridine. The formation of the N-anion causes aromatization of the tetrahydropyridine ring. Tetrahydropyrrolo-[1,2-c]pyrimidines are formed in the Trofimov reaction as a result of decomposition of the intermediate 3H-pyrrole in a retro-Mannich reaction

Catalytic dehydrocyclization of 3-isopropyl(n-propyl)-2,6-diphenylpyridine and 3-n-propyl-2,4,6-triphenylpyridine

The catalytic dehydrocyclization of 3-isopropyl-2,6-diphenylpyridine proceeds in two directions: conversion to 10-methyl-3-phenyl-4-azaphenanthrene and conversion to 9,9-dimethyl-4-azafluorene. C(9)-Unsubstituted 4-azafluorenes were obtained in the dehydrocyclization of pyridine bases that contain a phenyl group in the α position and an n-propyl group in the β position. © 1984 Plenum Publishing Corporation

M-CHOLINOLYTICS IN PREOPERATIVE PREPARATION OF CHILDREN WITH OBSTRUCTIVE UROPATHIES

The article highlights the results of oxybutinin hydrochloride m cholinolytics application in children with disorders of the adaptive urinary bladder function against the obstructive uropathy during the preoperative preparation. It shows the efficiency and safety of the intravesical medication injection, which allowed the researchers to cut the preoperative period in children with a combined pathology of the upper urinary tracts and expand the age range for the application of the given medication.Key words: urinary bladder dysfunctions, obstructive uropathy, oxybutinin hydrochloride, preoperative preparation, children

Heterocyclization of oximes of 3,5-dimethyl(1,3,5-trimethyl)-2,6- diphenylpiperid-4-ones and N-benzylpyrrolid-3-ones with acetylene in a superbasic medium

It has been established that on heterocyclization of 3,5-dimethyl-2,6- diphenylpiperid-4-one oxime with acetylene in a superbasic medium migration of the 3a-CH3 group to the anionic nitrogen atom occurs, leading to the formation of 5,7-dimethyl-4,6-diphenyl-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridine. The formation of the N-anion causes aromatization of the tetrahydropyridine ring. Tetrahydropyrrolo-[1,2-c]pyrimidines are formed in the Trofimov reaction as a result of decomposition of the intermediate 3H-pyrrole in a retro-Mannich reaction