Examples of MAI profiles.

<p>Confirmed Gleason score 7a (3+4, left) and Gleason score 8 (4+4, right) lesions.</p

Sensitivity, specificity and Youden index of MAI-based prostate cancer detection at different mean MAI threshold values.

<p>Sensitivity, specificity and Youden index of MAI-based prostate cancer detection at different mean MAI threshold values.</p

Comparison of computed MAI diagnostic accuracy with that of human readers based on PI-RADS scoring.

<p>Comparison of computed MAI diagnostic accuracy with that of human readers based on PI-RADS scoring.</p

Overview of MAI algorithm steps.

<p>Overview of MAI algorithm steps.</p

ROC plot of MAI diagnostic accuracy.

<p>ROC plot of MAI diagnostic accuracy.</p

Parameter settings of deployed multiparametric MRI sequences.

<p>Parameter settings of deployed multiparametric MRI sequences.</p

Example of a MAI map on a T2W image overlay.

<p>Example of a MAI map on a T2W image overlay.</p

Statistical results for halo-artifact reduction of the different scatter correction variants.

<p>Statistical results for halo-artifact reduction of the different scatter correction variants.</p

Comparison of halo-artifact appearance in PET/MR and PET/CT for ⁶⁸Ga and ¹⁸F-FDG.

<p>PET images of the pelvis phantom in coronal slice orientation using absolute SSS with MaxSF = 75%. The administered tracer was either ⁶⁸Ga or ¹⁸F-FDG and scans were performed subsequently in PET/CT (mCT) and PET/MRI (mMR). The mCT data were reconstructed twice: without and with TOF information. A severe halo-artifact surrounding the bladder insert was visible in all six cases.</p

Effects of different scatter correction variants on PET quantification.

<p>(A) Patient (52 years, 160 MBq ⁶⁸Ga-PSMA-11, 188 min p.i.) with prostate carcinoma (red arrow, Gleason score 9, confirmed by surgery). Mean and maximum standardized uptake values SUV_mean/SUV_max values evaluated in the pathological lesion indicated by the red arrow: 0/0 (Rel75), 3.0/8.3 (Abs75), 4.3/10.6 (Abs40). (B) Patient (66 years, 237 MBq ⁶⁸Ga-PSMA-11, 137 min p.i.) with biochemical recurrence after prostatectomy (red arrow, Gleason score 9, confirmed by surgery). SUV_mean/SUV_max values evaluated in the pathological lesion indicated by the red arrow: 5.3/8.6 (Rel75), 9.1/14.1 (Abs75), 11.3/17.6 (Abs40). Green arrows indicate physiology (ureters). Standardized 3D-isocontour (40% of SUVmax) was used for SUV quantification.</p