Six Years Observation After Successful Treatment of Bacterial Vaginosis

Objective: The cure rate after treatment of bacterial vaginosis (BV) differs in various investigations, but most studies report a cure rate of 70% after 1 month

Constructions of cospectral graphs with different zero forcing numbers

Several researchers have recently explored various graph parameters that can or cannot be characterized by the spectrum of a matrix associated with a graph. In this paper we show that several NP-hard zero forcing numbers are not characterized by the spectra of several types of associated matrices with a graph. In particular, we consider standard zero forcing, positive semidefinite zero forcing, and skew zero forcing, and provide constructions of infinite families of pairs of cospectral graphs which have different values for these numbers. We explore several methods for obtaining these cospectral graphs including using graph products, graph joins, and graph switching. Among these, we provide a construction involving regular adjacency cospectral graphs; the regularity of this construction also implies cospectrality with respect to several other matrices including the Laplacian, signless Laplacian, and normalized Laplacian. We also provide a construction where pairs of cospectral graphs can have an arbitrarily large difference between their zero forcing numbers

Improving Melanoma Classification by Integrating Genetic and Morphologic Features

Boris Bastian and colleagues present a refined morphological classification of primary melanomas that can be used to improve existing melanoma classifications by defining genetically homogeneous subgroups

Cop throttling number: Bounds, values, and variants

The cop throttling number thc(G) of a graph G for the game of Cops and Robbers is the minimum of k+captk(G), where k is the number of cops and captk(G) is the minimum number of rounds needed for k cops to capture the robber on G over all possible games in which both players play optimally. In this paper, we answer in the negative a question from [Breen et al., Throttling for the game of Cops and Robbers on graphs, {\em Discrete Math.}, 341 (2018) 2418--2430.] about whether the cop throttling number of any graph is O(n−−√) by constructing a family of graphs having thc(G)=Ω(n2/3). We establish a sublinear upper bound on the cop throttling number and show that the cop throttling number of chordal graphs is O(n−−√). We also introduce the product cop throttling number th×c(G) as a parameter that minimizes the person-hours used by the cops. We establish bounds on the product cop throttling number in terms of the cop throttling number, characterize graphs with low product cop throttling number, and show that for a chordal graph G, th×c(G)=1+rad(G)

Association of blood lead levels with onset of puberty in Russian boys

BACKGROUND: Epidemiologic studies suggest a temporal trend of earlier onset and longer duration of puberty, raising concerns regarding the potential impact of environmental factors on pubertal development. Lead exposure has been associated with delayed pubertal onset in girls; however, epidemiologic data in boys are limited. METHODS: We used multivariable logistic regression models to explore the cross-sectional association of blood lead levels with growth and pubertal onset based on physician-assessed testicular volume (TV) and pubertal staging in 489 boys 8-9 years of age from Chapaevsk, Russia. We used multivariable linear regression models to assess associations of blood lead levels with somatic growth at the study entry visit. RESULTS: The median (25th-75th percentile) blood lead level was 3 microg/dL (2-5 microg/dL). Height, weight, body mass index, birth weight, and gestational age were predictive of the onset of puberty as assessed either by TV (\u3e 3 mL), genitalia stage (G2), or both. Blood lead level was inversely associated with height (p \u3c 0.001) and weight (p = 0.06) after adjustment for birth weight, gestational age, and age at examination. In multivariable adjusted analyses, boys with blood lead levels \u3e or = 5 microg/dL had 43% reduced odds of having entered G2 compared with those with lower levels (odds ratio = 0.57; 95% confidence interval, 0.34-0.95, p = 0.03). CONCLUSIONS: Relatively low environmental blood lead levels were associated with decreased growth and differences in pubertal onset in periadolescent Russian boys. Future analyses of this prospective cohort will address pubertal onset and progression in relation to lead and other environmental chemicals

Association of Blood Lead Levels with Onset of Puberty in Russian Boys

Background: Epidemiologic studies suggest a temporal trend of earlier onset and longer duration of puberty, raising concerns regarding the potential impact of environmental factors on pubertal development. Lead exposure has been associated with delayed pubertal onset in girls; however, epidemiologic data in boys are limited. Methods: We used multivariable logistic regression models to explore the cross-sectional association of blood lead levels with growth and pubertal onset based on physician-assessed testicular volume (TV) and pubertal staging in 489 boys 8–9 years of age from Chapaevsk, Russia. We used multivariable linear regression models to assess associations of blood lead levels with somatic growth at the study entry visit. Results: The median (25th–75th percentile) blood lead level was 3 μg/dL (2–5 μg/dL). Height, weight, body mass index, birth weight, and gestational age were predictive of the onset of puberty as assessed either by TV (greater than 3 mL), genitalia stage (G2), or both. Blood lead level was inversely associated with height (p less than 0.001) and weight (p = 0.06) after adjustment for birth weight, gestational age, and age at examination. In multivariable adjusted analyses, boys with blood lead levels ≥ 5 μg/dL had 43% reduced odds of having entered G2 compared with those with lower levels (odds ratio = 0.57; 95% confidence interval, 0.34–0.95, p = 0.03). Conclusions: Relatively low environmental blood lead levels were associated with decreased growth and differences in pubertal onset in periadolescent Russian boys. Future analyses of this prospective cohort will address pubertal onset and progression in relation to lead and other environmental chemicals