71 research outputs found
Fibre Distribution and the Process-Property Dilemma
- Author
- A Alhuthali
- A Borges
- AY Dzenis
- B Delaunay
- BB Mandelbrot
- D Aniszewska
- D Purslow
- DEW Stone
- DM Shotton
- E Maire
- FC Blake
- FJ Guild
- FN Cogswell
- G Mayr
- G Voronoi
- GL Dirichlet
- HL Cox
- J Summerscales
- JD Miller
- L Mishnaevsky
- LF Richardson
- LG Stringer
- M Ferrando
- N Vernet
- NCW Judd
- NRL Pearce
- NRL Pearce
- PC Carman
- PJ Clark
- R Arbter
- R Lopes
- R Pitchumani
- RK Everett
- S Pimenta
- SR Ghiorse
- WR Cribb
- Y Wang
- YA Dzenis
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/11/2016
- Field of study
The options for the fibre reinforcement of polymer matrix composites cover a range from short-fibre chopped strand mat, through woven fabric to unidirectional pre-impregnated (prepreg) reinforcements. The modelling of such materials may be simplified by assumptions such as perfect regular packing of fibres and the total absence of fibre waviness. However, these and other features such as the crimp or waviness in woven fabrics make real materials more complex than the simplified models. Clustering of fibres creates fibre-rich and resin-rich volumes (FRV and RRV respectively) in the composites. Prior to impregnation, large RRV will be pore-space that can expedite the flow of resin in liquid composite moulding processes (especially resin transfer moulding (RTM) and resin infusion under flexible tooling (RIFT). In the composite, the clustering of fibres tends to reduce the mechanical properties. The use of image processing and analysis can permit micro-/meso-structural characterisation which may correlate to the respective properties. This chapter considers the quantification of microstructure images in the context of the process-property dilemma for woven carbon-fibre reinforced composites with the aim of increasing understanding of the balance between processability and mechanical performance
Effects of the Addition of Glucose, Sodium Bicarbonate, and Vitamin E to the Drinking Water of Pre-Slaughter Broiler Chickens on Carcass Yield, Gastric Emptying and Meat Quality
- Author
- Ali ASA
- Ali MS
- Almeida EG
- ASC Pereira
- Barbut S
- Beraquet NJ
- Berri C
- Borges SA
- Boschini C
- Castro JBJ
- CHF Domingues
- Denadai JC
- Duke GE
- ET Santos
- Froning GW
- Karacay N
- Leonel FR
- Lyon BG
- Lyon CE
- Lyon CE
- Mendes AA
- Mendes AA
- Northcutt JK
- Novello D
- OM Junqueira
- Rasmussen AL
- Rui BR
- RX Rocha
- Schettino DN
- Souza Junior FN
- Souza PA
- Souza VLF
- TG Petrolli
- Warriss PD
- Whiting TS
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Snakebite cases in the municipalities of the State of Paraiba, Brazil
- Author
- Albuquerque HN
- Borges CC
- Carrasco PA
- Feitosa RFG
- Feliciano MLM
- Gutiérrez JM
- Hellyson Fidel Araujo De Oliveira
- Jackeline Araujo Pasquino
- Jorge Alves Sousa
- Kasturiratne A
- Kouyoumdjian JA
- Laisla Rangel Peixoto
- Lemos JC
- Lima JS
- Lira-da-Silva RM
- Machado C
- Mise YF
- Moreira ERF
- Oliveira FN
- Oliveira HFA
- Otero-Patinõ R
- Pinho FMA
- Pinho FMO
- Rafaella Moreno Barros
- Renner de Souza Leite
- Rojas CA
- Silva FG
- Theakston RDG
- Waldez F
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Evaluating the effectiveness of the customized Unna boot when treating patients with venous ulcers*
- Author
- Abbade LPF
- Adriana Rodrigues dos Anjos Mendonça
- Aguiar ET
- Bajay HM
- Baptista CMC
- Bergonse FN
- Borges EL
- Borges EL
- Borges EL
- Bruna Suelen Raymundo Luz
- Cordts PR
- Cristina Souza Araujo
- Cullum N
- Dealey C
- Dênia Amélia Novato Castelli Von Atzingen
- Ferreira AM
- Frade MAC
- Freitas MAS
- Guest M
- Guimarães Barbosa JA
- Koksal C
- Lopes AR
- Maffei FHA
- Magalhães MN
- Marcos Mesquita Filho
- Mauricéia Lins de Medeiros
- Moreira JW
- Neter J
- Orosco SS
- Partsch H
- Vowden K
- Yamada BFA
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
ACUTE KIDNEY INJURY CAUSED BY Crotalus AND Bothrops SNAKE VENOM: A REVIEW OF EPIDEMIOLOGY, CLINICAL MANIFESTATIONS AND TREATMENT
- Author
- Adukauskiene D
- Amaral CFS
- Amaral CFS
- Barone JM
- Barraviera B
- Bochner R
- Boer-Lima PA
- Boer-Lima PA
- Borges CC
- Bosch X
- Braga MD
- Bucaretchi F
- Burdmann EA
- Camilla N. Jacinto
- Castro I
- Chippaux JP
- Chippaux JP
- Cupo P
- Daher EF
- Elizabeth F. Daher
- Feitosa R
- Frezzatti R
- Geraldo B. Silva Junior
- Ghosh MK
- Gutiérrez JM
- Gutiérrez JM
- Juliana B. Lima
- Kanjanabuch T
- Lima JS
- Macedo E
- Maria do Socorro B. Veras
- Mise YF
- Molander M
- Monteiro HS
- Nascimento JM
- Oliveira FN
- Otero-Patiño R
- Pinho FM
- Pinho FM
- Pinto RNL
- Polianna L.M.M. Albuquerque
- Santos MFL
- Saul ME
- Sgrinolli L
- Silva HA
- Silveira PV
- Sitprija V
- Sitprija V
- Sitprija V
- Sitprija V
- Vêncio D
- Walker JP
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Promoter Complexity and Tissue-Specific Expression of Stress Response Components in Mytilus galloprovincialis, a Sessile Marine Invertebrate Species
- Author
- A Anestis
- A Clarke
- A Koga
- A Kourtidis
- A Laubriet
- AD Bradshaw
- AF Muttray
- AF Muttray
- AJ Enright
- AM Waterhouse
- AP Diz
- B Chen
- B Hamer
- B Hamer
- B Helmuth
- BR Broitman
- C Jiang
- Christos A. Ouzounis
- Chrysa Pantzartzi
- CM Barker
- CN Pantzartzi
- CW Walker
- D Vlieghe
- D Walerych
- D Walerych
- DR Filpula
- DS Chekmenev
- E Boon
- E Galimany
- E Hickey
- E Sodergren
- Elena Drosopoulou
- EP Dahlhoff
- F Dondero
- F Murray-Zmijewski
- FN Hamada
- G Mitta
- GE Hofmann
- GE Hofmann
- HG Silverman
- Ignat Drozdov
- IM Weiss
- J Kaur
- J Schug
- JE FitzGerald
- K Nanbu
- K Roy
- L Tomanek
- L Tomanek
- LE Petes
- LL Moroz
- LR Shugart
- M Banni
- M Berriman
- M Kaloyianni
- M Stifanic
- M Yuki
- M Zylicz
- MA Larkin
- ME Dillon
- MG Parisi
- Minas Yiangou
- MV Blagosklonny
- N Grabe
- N Holten-Andersen
- NC Mestre
- NF Rebbe
- NF Rebbe
- NH Putnam
- P Muller
- P Venier
- P Venier
- P Venier
- Philip E. Bourne
- R Zhao
- RB Huey
- RE Barrow
- RJ Petit
- RK Blackman
- RL Strausberg
- RM Borges
- RM Coulson
- RM Coulson
- S Bachali
- S Gorina
- S Richardt
- S Rudiger
- S Whalan
- SF Altschul
- SH Shiu
- SJ Jones
- SL Zhang
- SN Agoff
- Sophia Tsoka
- T Cavalier-Smith
- T Inoue
- WR Swindell
- WR Swindell
- Y Gong
- Y Maehara
- Y Shen
- Y Shiio
- Y Zhang
- Zacharias G. Scouras
- ZP Feng
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
The mechanisms of stress tolerance in sessile animals, such as molluscs, can offer fundamental insights into the adaptation of organisms for a wide range of environmental challenges. One of the best studied processes at the molecular level relevant to stress tolerance is the heat shock response in the genus Mytilus. We focus on the upstream region of Mytilus galloprovincialis Hsp90 genes and their structural and functional associations, using comparative genomics and network inference. Sequence comparison of this region provides novel evidence that the transcription of Hsp90 is regulated via a dense region of transcription factor binding sites, also containing a region with similarity to the Gamera family of LINE-like repetitive sequences and a genus-specific element of unknown function. Furthermore, we infer a set of gene networks from tissue-specific expression data, and specifically extract an Hsp class-associated network, with 174 genes and 2,226 associations, exhibiting a complex pattern of expression across multiple tissue types. Our results (i) suggest that the heat shock response in the genus Mytilus is regulated by an unexpectedly complex upstream region, and (ii) provide new directions for the use of the heat shock process as a biosensor system for environmental monitoring
EPIDEMIOLOGICAL PROFILE OF SNAKEBITE ACCIDENTS IN A METROPOLITAN AREA OF NORTHEAST BRAZIL
- Author
- Aguiar M
- Bochner R
- Borges C
- Camilla N. Jacinto
- Caroline B. Lima
- Correia JM
- Elizabeth F. Daher
- Feitosa RF
- Fundação Nacional de Saúde
- Geraldo B. Silva Junior
- Guimarães J
- Juliana B. Lima
- Lemos JC
- Lima AC
- Lima JS
- Maria do Socorro B. Veras
- Mise YF
- Oliveira FN
- Pacheco UP
- Pinho FM
- Pinho FM
- Polianna L.M.M. Albuquerque
- Santos MF
- Sgrignolli L
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Evaluation of oxidative stress parameters and metabolic activities of nurses working day and night shifts
- Author
- Abdussamet Hazar
- Almeida GJ
- Berntsen S
- Borges FN
- Buyukhatipoglu H
- Buyukhatipoglu H
- Camerino D
- Clissold G
- Corradi-Webster CM
- De Martino MM
- Dorrian J
- Erel O
- Fischer FM
- Fitzmaurice SD
- Flore R
- Hakan Buyukhatipoglu
- Halliwell B
- Ä°brahim Can Kurkcuoglu
- Idris Kirhan
- Ishihara I
- Mehmet Ali Eren
- Mehmet Emin Demir
- Mehmet Sinan Dal
- Mehmet Ucar
- Nasrabadi AN
- Nurten Aksoy
- Pafaro RC
- Portela LF
- Sevilay Ulas
- Sharifian A
- Trinkoff A
- Tsuboi H
- Turgay Ulas
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
- Andrade R
- Annessi V
- Annicchiarico A
- Antonakis P
- Antonopoulou M
- Aprile A
- Aremu M
- Arias-Amezquita F
- Aribi N
- Aribi S
- Arkadopoulos N
- Armao T
- Armatura G
- Arminio A
- Arnaud Alexis P
- Arora A
- Arslan K
- Ashoush F
- Athanasakis E
- Attia D
- Augestad Knut Magne
- Aversano A
- Avlund T
- Awada Barakat J
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Ayub B
- Ayubi A
- Ayyaz M
- Azevedo C
- Azevedo J
- Azevedo Jose
- Azevedo P
- Azman Mohd ZA
- Azzam AY
- Babalola O
- Badra R
- Bagraith K
- Baili E
- Balabel M
- Balconi A
- Baldari L
- Baldi C
- Baldini E
- Bali K
- Ballabio M
- Ballouhey Q
- Baloyiannis I
- Bandovas JP
- Bankhead-Kendall Brittany K
- Banky B
- Banuelos Romero E
- Baptista VH
- Barker D
- Barlow Emma
- Barod Ravi
- Barone R
- Baronio G
- Barrat B
- Barros Vieira A
- Bartalucci B
- Bartolini I
- Bashir Y
- Bass G
- Batistotti P
- Batstone Martin
- Baxevanidou K
- Beard David
- Becker R
- Bekele K
- Belia F
- Belkhadir ZH
- Bellacci A
- Belli A
- Bellolio F
- Bellora P
- Belluco C
- Belvedere A
- Bendjemar L
- Benkabbou A
- Benson Ruth A
- Bergamini C
- Bergeat D
- Bernante P
- Berselli M
- Bertelli G
- Bertolani E
- Besser N
- Beyer K
- Beyrne C
- Bezerra Santos T
- Bhangu Aneel A
- Bhat GA
- Bhat MA
- Biala M
- Bianchini M
- Bianco F
- Biel Juan Rey
- Bigam D
- Biondi A
- Birolo SL
- Bisagni P
- Blanco-Colino Ruth
- Bodanese B
- Boeker C
- Bondurri A
- Bong C
- Boni L
- Bonilla A
- Bonnet S
- Bordoni P
- Borges Castro F
- Borges N
- Borghi F
- Bork U
- Borroni G
- Bouchagier K
- Bouche PA
- Bouliaris K
- Boutros M
- Bowman S
- Boyce R
- Brachini G
- Bradulskis S
- Braham H
- Brar Amanpreet
- Bravo Ana Minaya
- Breen Kerry A
- Bretherton Chris
- Bristow Rob
- Bromage Steve
- Brown C
- Brunelli Alessandro
- Bruscino A
- Buarque Igor Lima
- Buarque Lima
- Bucci Fares A
- Buerba GA
- Burgan D
- Burke Joshua
- Butt U
- Bywater Edward
- Caccetta M
- Calabro M
- Camacho C
- Camara P
- Camarneiro R
- Caminsky N
- Campagnaro T
- Canas-Martinez A
- Canonico G
- Capelli P
- Capezzuoli L
- Capolupo GT
- Capunge I
- Caram EL
- Carannante F
- Carbone F
- Carcoforo P
- Cardoso N
- Cardoso P
- Carissimi F
- Caruana Edward J
- Carvello MM
- Casati M
- Cassinotti E
- Catena F
- Cecire J
- Ceelen W
- Ceretti Pisani A
- Cervellera M
- Cetares C
- Chaar Mohammad
- Chakrabortee Sohini
- Chan E
- Charalabopoulos A
- Charre L
- Chaturvedi A
- Chaturvedi H
- Chatzikomnitsa P
- Chaudhry Daoud
- Chebaro A
- Chen S
- Chessa A
- Chiappini A
- Chiarugi M
- Chinda J
- Chiozza M
- Chisthi M
- Chiva Luis
- Choong E
- Chowdri N
- Christensen P
- Christensen Peter
- Christidis P
- Christou C
- Chrysos E
- Chumbinho B
- Cianflocca D
- Cicerchia PM
- Cirillo B
- Clarizia G
- Claro M
- Coccolini F
- Cocozza E
- Coelho Nunes M
- Coffey JC
- Cohen Paul
- Colletti G
- Colombo F
- Colquhoun Alexandra
- Confalonieri M
- Connelly T
- Conti L
- Contis I
- Coonar Aman S
- Corbellini C
- Cordera F
- Corless K
- Corrigan M
- Cosentino Marino L
- Cosimelli M
- Costa M
- Costa Matos P
- Costa MJMA
- Costanzi A
- Costeira B
- Cotoia A
- Cotte E
- Cox Daniel
- Cozza V
- Creavin B
- Cremonini C
- Crespo A
- Cuasquen Velasquez BG
- Cukier M
- Cukier Moises
- Cullivan O
- Cunha C
- Cunha MF
- Cunha Miguel F
- Cunha R
- Cunningham RM
- D'Aloisio G
- D'Ugo D
- D'Ugo S
- D'Urso A
- da Cruz Lima L
- da Silva Abreu A
- da Silva Lima C
- Dainius E
- Dajani K
- Daly A
- Danias N
- Davidson Giana H
- Dawson AC
- Dawson Brett E
- de Almeida Ramalho F
- de Barros Figueiredo
- De Lima RK
- De Lucia F
- De Nardi P
- De Palma G
- de Sa Correia T
- de Sampaio Regina L
- De Simone V
- De Sousa X
- De Toma G
- De Troia A
- De Vincenti R
- Deirino A
- Delinasios G
- Dell A
- Della Giustina E
- Dellaportas D
- Delrio P
- Demetriades Andreas K
- Demyttenaere S
- Denet C
- Depalma N
- Derksen T
- Desai Anant
- Desio M
- Desoouza A
- Deus AC
- Devarakonda S
- Devezas V
- Devine M
- Dhamija P
- Dharanipragada K
- Di Bella A
- Di Franco G
- Di Lauro K
- Di Martino C
- Di Marzo F
- Di Saverio Salomone
- Diamantis A
- Diaz P
- Dijan E
- Domingues J
- Donati D
- dos Santos Martins G
- Doudakmanis C
- Dowdy Sean
- Doyle A
- Drake Thomas M
- Drane A
- Droghetti M
- Duchalais E
- Dudi-Venkata NN
- Dumitra Sinziana
- Duran Sosa EE
- Earley H
- Eastmond A
- Ebbehoj AL
- Ebben L
- Economopoulou P
- Edwards John
- Edwards John G
- Efthimiou M
- Egoroff N
- El Ahmadi B
- El Amrani M
- El Arbi N
- El Bouazizi Y
- El Kassas M
- Elazzazy E
- Eldaly A
- Elghazaly MS
- Elhadi Muhammed
- Elliott JA
- Ellojli I
- Elmorsi R
- Emile Sameh
- Emmanuel K
- Enoch E
- Esene Ignatius
- Eskinazi DG
- Esposito G
- Esquide Ruiz M
- Essam E
- Evans Jonathan P
- Evans Richard PT
- Eveno C
- Ewedah M
- Ezanno AC
- Fabbri N
- Facundo H
- Fagotti Anna
- Fahey BA
- Fahmawee T
- Farik Shebani
- Farnesi F
- Farooka MW
- Fathi NQ
- Faustino A
- Fayed Y
- Federico P
- Federico Pipitone NS
- Feo C
- Feo CF
- Fernandes Sousa M
- Fernandes U
- Fernandes V
- Ferrari M
- Ferrario L
- Ferraz I
- Ferreira C
- Ferreira Peralta M
- Ferro Carvalho C
- Ferro Rey M
- Finnegan L
- Fiore M
- Fiore Marco
- Fiori E
- Fiorini A
- Fitzgerald J Edward
- Flamey N
- Fleming CA
- Fleres F
- Fonsi GB
- Foo CC
- Foppa C
- Ford Samuel
- Fortuna L
- Fotopoulou Christina
- Fountain Daniel M
- Fowler A
- Frade S
- Fragoso M
- Francone E
- Franken J
- Frantzeskou K
- Franzini M
- Frattaruolo C
- Frazao J
- Fredon F
- Freitas A
- Frena A
- Freyschlag Christian
- Fritzmann J
- Frongia F
- Frountzas M
- Fujiwar Keiichi
- Fuks D
- Furbetta N
- Futaba K
- Gahwagi M
- Gallo G
- Gallo Gaetano
- Galvao D
- Gani J
- Ganly Ian
- Garba S
- Garberini De Manzoni A
- Garcia JS
- Garfinkle R
- Garg PK
- Garino M
- Garmanova Tatiana
- Garrido R
- Gattolin A
- Gauri N
- Gaziants V
- Gelarda E
- Gennari S
- Gentilli S
- George G
- Gerns N
- Geroukalis A
- Ghaly G
- Ghamgh R
- Ghannam A
- Ghebre Rahel
- Ghitulescu G
- Ghosh Dhruva
- Giacometti M
- Giaglaras A
- Gianardi D
- Gill R
- Gillis AE
- Giraudo G
- Giuffrida M
- Giuffrida MC
- Giunta A
- Gklavas A
- Glasbey James C
- Glehen O
- Gold-Deutch R
- Gomes GMA
- Gomes Gustavo Mendonca Ataide
- Gomes J
- Gomez-Mayorga JL
- Gori A
- Gouvas N
- Grasset E
- Grasso M
- Grechenig M
- Grechi A
- Grecinos Gustavo
- Gribnev P
- Griffiths Ewen A
- Grilo J
- Grimaldi Di Maria S
- Gronchi Alessandro
- Groot G
- Grossi U
- Grotenhuis BA
- Gruber R
- Gruendl Magdalena
- Guadagni S
- Guaglio M
- Guerci C
- Guerra GR
- Guevara O
- Guglielmi A
- Guidi G
- Gujjuri Rohan R
- Gundara J
- Gupta S
- Gutelkin Murat
- Hakami I
- Halkias Constantine
- Hamdan KH
- Hamdy R
- Hamza HM
- Hanly A
- Haque PD
- Harald M
- Harbjerg JL
- Hardy NP
- Harris Benjamin
- Harrison Ewen M
- Hartveld L
- Hasan Aboharp Z
- Hassan E
- Hayati F
- Helminen O
- Heneghan H
- Henriques P
- Henriques S
- Heritage Emily
- Hernandez R
- Herzberg J
- Hisham Intisar
- Hmedat A
- Ho D
- Ho MF
- Ho Michael
- Hoffmann P
- Hogan A
- Hompes R
- Hon S
- Honarpisheh H
- Huhta H
- Hussain AH
- Hutchinson Peter
- Hutchinson Peter J
- Hwang Shelley
- Iannone I
- Ibrahim AF
- Ijichi TR
- Impellizzeri H
- Inama M
- Incollingo P
- Inzunza M
- Ioannidis O
- Ipponi P
- Isaac John
- Isik Arda
- Islam AA
- Isolani SM
- Isoton JC
- Iversen LH
- Izbicki J
- Izzo F
- Jacome F
- Jager T
- Jain A
- Jain D
- Jain M
- Jamal A
- Jang S
- Janik M
- Jayasilan J
- Jenkinson Michael D
- Jesudason MR
- Jeyaraj P
- Jeyarajan E
- Ji Almeida
- Jia F
- Jo Bello
- Joao Alagoa A
- Jobran F
- Jocson R
- Jones Conor S
- Jonescheit J
- Jonker Pascal
- Jordan P
- Jordan S
- Jouffret L
- Jovine E
- Jusoh Che A
- Jw Mall
- Kaafarani Haytham MA
- Kalayarasan R
- Kalfountzos C
- Kamal N
- Kamarajah Sivesh K
- Kamoka E
- Kamphues C
- Kanemitsu Y
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- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
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- Adamu AA
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- Adelson JD
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- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
- …