Stress, health and coping among international students at the University of Malta

This is the Second Monograph in Resilience and Health, Centre for Resilience and Socio-Emotional Health, University of Malta, 2014. The authors would like to express their gratitude to all the international students who participated in this study; to Prof Liberato Camilleri (University of Malta) for his help with the statistical analysis; and to Dr Valeria Cavioni (University of Pavia) for the design of the monograph’s cover and layout.This study explores the perceived health and wellbeing of international students at the University of Malta. More specifically it examines the personal and academic concerns and challenges of international students, their perceived stress, health and coping, and whether these vary by gender, language and country of origin, and how they compare with the health of Maltese university students (as reported in Cefai & Camilleri, 2009).peer-reviewe

Two decades of action on nutrition for the Maltese population

Malta, like many other countries, has experienced significant challenges in nutrition over the past 20 years. Given the increasing prevalence of diet-related diseases and overweight and obesity across all ages, nutrition has been high on the Ministry for Health agenda over the past 15 years. Public Health practitioners in Malta have been drivers of public health nutrition reform throughout this period. The Health Promotion and Disease Prevention Directorate was set up to mainly focus on health promotion and non-communicable diseases including healthy nutrition in 2007. Over the years a number of strategies have been outlined targeting nutrition for the Maltese population including the Non Communicable Disease Strategy, the National Cancer Plan, the National Healthy Weight for Life Strategy, the Food and Nutrition Policy and Action Plan for Malta, Diabetes: A National Public Health Priority – A National Strategy for Diabetes 2016-2020, Whole of School Approach to Healthy Lifestyle: Healthy Eating and Physical Activity Policy and Strategy and the National Breastfeeding Policy and Action Plan 2015 – 2020. With input from WHO and the EU, Malta has participated in many surveys allowing for continuous monitoring and evaluation. In 2015, Malta embarked on a first National Food Consumption Survey, results of which will provide a baseline on eating habits to target priority areas for action, inform policy and monitor trends.peer-reviewe

Evaluation and optimization of in silico designed β-Secretase modulators for the treatment of "Alzheimer's Disease"

Alzheimer's disease affects cognitive function through formation of ß- secretase mediated extracellular cerebral protein plaques and intracellular neurofibrillary tangles, thus its antagonism could mitigate disease progression. This project aims to identify newly obtained and optimized molecules which decrease the formation of ß -amyloid plaques through inhibition of the ß- secretase enzyme. Protein databank (PDB) depositions describing the bound coordinates of 6 lead structures complexed with ß- secretase were identified (PDB ID- 2VKM, 4B05, 4IVS, 3U6A, 3IGB, 2Q11) as leads for in silico ligand based and de novo design of novel antagonist molecules. For the first part of this study, ligands extracted from the protein were used as templates for screening ViCi Hamburg‟s database. Protomols were generated for each of the ligands using the Surflex Dock suite in SYBYL-X. The molecules received through ViCi were then used as ligand sources. For the second part of the study the ligand binding affinity (LBA) of each small molecule for its cognate receptor was calculated in X-Score for baseline affinity establishment. 2D topology maps highlighting the important interactions between ligand and receptor were generated using Poseview, and noncritical moieties were computationally removed in the process of creating seed structures (n=3, 2, 3,2,2,2 respectively) on to which novel moieties were computationally introduced using the GROW module of LigBuilder. Protomol and Keysite volumes were then compared using UCSF Chimera. 1636 novel structures were generated with 253 structures being Lipinski Rule compliant. The highest ranking molecules from each pharmacophoric family were identified for optimization and in vitro validation.peer-reviewe

The needs of Maltese families with dependent children : a focus group study among professionals

This article seeks to identify the needs of Maltese families with dependent children. The sociocultural context in which Maltese families are embedded will serve as a theoretical framework for this study. A series of six focus groups with experts in the area of family and children were moderated for the purpose of the study. These focus group sessions were audiotaped and transcribed and the results analysed using thematic analysis. This article draws on the findings of these focus groups and compares them to extant literature on Maltese families before making a number of policy recommendations. Three key themes were elicited: the need for more community work and early intervention; the need for education for life; and the need to support families achieve work-life balance. The main recommendations are: the set-up of family centres for community work and early intervention; the implementation of relationship education programmes; and more family-friendly working practices.peer-reviewe

Stereocontrolled access to δ-lactone-fused-γ-lactams bearing angular benzylic quaternary stereocenters

C-fused γ-lactam-lactones are resident in several bioactive molecules, including anticancer agents such as omuralide. In this embodiment, we report mild conditions for the catalytic halolactonization of lactam-tethered 5-aryl-4(E)-pentenoic acids. The use of dichloromethane as the solvent and Ph3PS as the catalyst led to predominant 6-endo-trig cyclization and furnished the trans-fused-γ-lactam-δ-lactones. The transformation is modular, regioselective, chemoselective, and diastereoselective. The γ-lactam-δ-lactones bear angular quaternary benzylic stereocenters, which is noteworthy since the presence of a quaternary carbon in bioactive small molecules often promotes an element of conformational restriction that imparts potency, selectivity, and metabolic stability. The generated halogen and lactone motifs are important functional handles for late-stage diversification

Contra-thermodynamic halolactonization of lactam-tethered 5-aryl-4(E)-pentenoic acids for the flexible and stereocontrolled synthesis of fused lactam-halolactones

Halolactonization of alkenoic acids enables the construction of oxygen-heterocycles via intramolecular halonium-induced nucleophilic addition. Although the literature is currently inundated with halolactonizations of 5-aryl-4(E)-pentenoic acids that predictably afford the 6-endo cyclization adducts, methods that reliably alter the innate regioselectivity bias to instead deliver the thermodynamically less favored 5-exo cyclization products are relatively rare. Here, we attempt to bridge this gap and have found mild conditions for contra-thermodynamic halolactonization of lactam-tethered 5-aryl-4(E)-pentenoic acids that lead to the formation of trans-fused lactam-γ-lactones. The natural proclivity for these 5-aryl-4(E)-pentenoic acids to undergo 6-endo cyclization is overridden and 5-exo-trig cyclization predominates. The success of the approach hinges on the use of N,N-dimethylformamide (DMF) as the solvent and N-methylmorpholine oxide as the catalyst. The lactam-lactone products are synthesized in high diastereoselectivity, modularity, and chemoselectivity. Notably, most of the bicycles contain one benzylic quaternary stereocenter as well as an α-alkoxy quaternary stereocenter

Preventing healthcare-associated MRSA bacteremia : getting to the root of the problem

Bloodstream infections caused by methicillin-resistant Staphylococcus aureus (MRSA) remain a major challenge in most countries worldwide. Setting: We describe a quasi-experimental sequential intervention at Mater Dei Hospital, Malta, to reduce hyper-prevalence of healthcare-associated MRSA bacteremia (HA-MRSA-B). Interventions: The hospital initiated a hand hygiene (HH) campaign in 2008 to improve alcohol hand rub (AHR) use. In 2011, this was followed by root cause analysis (RCA) of all HA-MRSA-B cases and finally universal MRSA admission screening in 2014. Change-point analysis was used to evaluate the impact of the interventions. Results: The effect of the HH campaign became evident when AHR consumption reached 40 L/1000 occupied bed days (BD). RCAs identified intravascular devices as the likely risk factor in 83% of all HA-MRSA-B; specifically non-tunneled double-lumen hemodialysis catheters (36%), peripheral venous cannulas (25%), and central venous catheters (22%). Interventions to improve their management resulted in the greatest reduction of HA-MRSA-B rates. They were informed by the RCA findings and targeted behavior change through education, motivation, and system change. Universal MRSA admission screening provided the final decline in incidence. Each intervention affected HA-MRSA-B rates after a lag period of approximately 18–24 months. Overall, HA-MRSA-B incidence decreased from 1.72 cases/10000BD in 2008 to 0.18/10000BD in 2019; a reduction of almost 90%. Intravenous device interventions were also associated with a reduction of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia rates. Conclusions: Significant improvement in HA-MRSA-B is possible, even in highly endemic regions. It requires well-planned behavior change interventions which are compatible with local context and culture.peer-reviewe

Serendipitous synthesis of cross-conjugated dienes by cascade deconstructive esterification of thiomorpholinone-tethered alkenoic acids

Functionalized 1,3-dienes are ubiquitous structural motifs in biologically pertinent molecules. They are frequently employed as precursors for a broad range of chemical transformations, including Diels-Alder reactions. The stereoselective construction of highly decorated 1,3-dienes therefore represents an important research objective. Medicinal chemists are becoming increasingly interested in synthetic methodologies that not only achieve expedient construction and peripheral editing of heterocycles, but also seek to modify their core framework in order to achieve skeletal remodeling. In a succinct manifestation of this \u27scaffold hopping\u27 concept, we herein describe a cascade reaction, which converts thiomorpholinone-tethered alkenoic acids to 1,1-disubstituted amino-1,3-dienes. This domino process involves esterification of the acid, base-assisted ring-opening, and concomitant 1,2-migration of the alpha-amino alkenyl group. Several control experiments have revealed that the alkenyl substituent is necessary for deconstruction to occur. Inherently more activated N-aryl-substituted thiomorpholinone acids react significantly faster than their less activated N-alkyl congeners

Quality of care in a paediatric emergency department

Background: Measuring quality of care in a paediatric emergency department is challenging and there is lack of specific set measures to do so. The primary objective of this study was to determine the quality of care in our local paediatric emergency department by applying a set of quality indicators. The secondary objectives were to determine lacunae in quality of care and thus make suggestions for improvement.Methods: A retrospective study was carried out using data collected from records of children presenting to the paediatric emergency department with a medical complaint between August and December 2019, during the first two weeks of each month. The Institute of Medicine Quality Domains were used to assess the quality indicators measured.Results: Specific quality indicators require improvement including weight documentation, time to triage, and safety netting practices. A lack of quality indicators measuring patient-centeredness, staff experience, and equity was noted.Conclusion: Suggestions, both for improving quality of care and its measurement, are made, in light of the new challenges faced by paediatric emergency departments.peer-reviewe

The 2023 WebNLG Shared Task on Low Resource Languages. Overview and Evaluation Results (WebNLG 2023)

The WebNLG task consists of mapping a knowledge graph to a text verbalising the con- tent of that graph. The 2017 WebNLG edi- tion required participating systems to gener- ate English text from a set of DBpedia triples, while the 2020 WebNLG+ challenge addition- ally included generation into Russian and se- mantic parsing of English and Russian texts. In contrast, WebNLG 2023 focuses on four under-resourced languages which are severely under-represented in research on text genera- tion, namely Breton, Irish, Maltese and Welsh. In addition, WebNLG 2023 once again includes Russian. In this paper, we present the organi- sation of the shared task (data, timeline, eval- uation), briefly describe the participating sys- tems and summarise results for participating systems