Screening af hangrise - meddelelse nr. 996

En screening af 9 hangrisebesætninger viste, at frasorteringsprocenten alene baseret på skatoltallet var 2,3%. En sortering på baggrund af human nose gav 11% frasorterede, og der var 37% af hangrisene, der lå over 1.0 ppm androstenon

Multi-level Hydrodynamic Modelling of a Scaled 10MW TLP Wind Turbine

AbstractIn the present paper the accuracy of three numerical models for a scaled 10MW TLP wind turbine is assessed by comparison with test data. The three models present different levels of complexity, and therefore different degrees of accuracy can be expected. A set of load cases including irregular and focused waves is run in the three models, where only wave loads are considered. The simulation results are compared against the test data, and the numerical models are assessed based on their ability to reproduce the test results. Finally, the possibility of enhancing the simple model by using the advanced models is discussed

An efficient frequency-domain model for quick load analysis of floating offshore wind turbines

A model for Quick Load Analysis of Floating wind turbines (QuLAF) is presented and validated here. The model is a linear, frequency-domain, efficient tool with four planar degrees of freedom: floater surge, heave, pitch and first tower modal deflection. The model relies on state-of-the-art tools from which hydrodynamic, aerodynamic and mooring loads are extracted and cascaded into QuLAF. Hydrodynamic and aerodynamic loads are pre-computed in WAMIT and FAST, respectively, while the mooring system is linearized around the equilibrium position for each wind speed using MoorDyn. An approximate approach to viscous hydrodynamic damping is developed, and the aerodynamic damping is extracted from decay tests specific for each degree of freedom. Without any calibration, the model predicts the motions of the system in stochastic wind and waves with good accuracy when compared to FAST. The damage-equivalent bending moment at the tower base is estimated with errors between 0.2&thinsp;% and 11.3&thinsp;% for all the load cases considered. The largest errors are associated with the most severe wave climates for wave-only conditions and with turbine operation around rated wind speed for combined wind and waves. The computational speed of the model is between 1300 and 2700 times faster than real time.</p

Hemodynamic changes during aortic valve surgery among patients with aortic stenosis

Introduction. Patients with severe aortic stenosis (AS) undergoing surgery are at increased risk of hypotension and hypoperfusion. Although treatable with inotropic agents or fluid, little is known about how these therapies affect central hemodynamics in AS patients under general anesthesia. We measured changes in central hemodynamics after dobutamine infusion and fluid bolus among patients with severe AS and associated these changes with preoperative echocardiography. Methods. We included 33 patients with severe AS undergoing surgical AVR. After induction of general anesthesia, hemodynamic measurements were obtained with a pulmonary artery catheter, including Cardiac index (CI), stroke volume index (SVi) and pulmonary capillary wedge pressure (PCWP). Measurements were repeated during dobutamine infusion, after fluid bolus and lastly after sternotomy. Results. General anesthesia resulted in a decrease in CI and SVi compared to preoperative values. During dobutamine infusion CI increased but mean SVi did not (38 ± 12 vs 37 ± 13 ml/m², p = .90). Higher EF and SVi before surgery and a larger decrease in SVi after induction of general anesthesia were associated with an increase in SVi during dobutamine infusion. After fluid bolus both CI, SVi (48 ± 12 vs 37 ± 13 ml/min/m², p < .0001) and PCWP increased. PCWP increased mostly among patients with a larger LA volume index. Conclusion. In patients with AS, CI can be increased with both dobutamine and fluid during surgery. Dobutamine’s effect on SVI was highly variable and associated with baseline LVEF, and an increase in CI was mostly driven by an increase in heart rate. Fluid increased SVi at the cost of an increase in PCWP

Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma

BACKGROUND: Neuroinflammation is recognized as part of the pathological progression of Alzheimer's disease (AD), but the molecular mechanisms are still not entirely clear. Systemically, physical exercise has shown to have a positive modulating effect on markers of inflammation. It is not known if this general effect also takes place in the central nervous system in AD. The aim of this study was to investigate the effect of 16 weeks of moderate to high-intensity physical exercise on selected biomarkers of inflammation both systemically and in the CNS, in patients with AD. METHODS: Plasma and cerebrospinal fluid (CSF) from 198 patients with Alzheimer's disease participating in the Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) study were analyzed for concentrations of 8‑isoprostane, soluble trigger receptor expressed on myeloid cells 2 (sTREM2), and the MSD v-plex proinflammation panel 1 human containing interferon gamma (IFNγ), Interleukin-10 (IL10), IL12p70, IL13, IL1β, IL2, IL4, IL6, IL8, and tumor necrosis factor alpha (TNFα), before and after a 16-week intervention with physical exercise, and we studied whether changes were modulated by the patients' APOE genotype. RESULTS: Most inflammatory markers remained unchanged after exercise. We found an increasing effect of 16 weeks of physical exercise on sTREM2 measured in CSF. Further, IL6 in plasma increased in the exercise group after physical exercise (mean relative change 41.03, SD 76.7), compared to controls (-0.97, SD 49.4). In a sub-analysis according to APOE genotype, we found that in ε4 carriers, exercise had a stabilizing effect on IFNγ concentration with a mean relative change of 7.84 (SD 42.6), as compared to controls (114.7 (SD 188.3), p = 0.038. CONCLUSION: Our findings indicate an effect of physical exercise on markers of neuroinflammation in CSF measured by an increase in sTREM2 in patients with AD. Further, there may be a small inflammatory systemic effect related to physical exercise in patients with AD