Nuclear dependence coefficient α(A,qT)\alpha(A,q_T) for the Drell-Yan and J/ψ\psi production

Define the nuclear dependence coefficient $\alpha(A,q_T)$ in terms of ratio of transverse momentum spectrum in hadron-nucleus and in hadron-nucleon collisions: $\frac{d\sigma^{hA}}{dq_T^2}/ \frac{d\sigma^{hN}}{dq_T^2}\equiv A^{\alpha(A,q_T)}$. We argue that in small $q_T$ region, the $\alpha(A,q_T)$ for the Drell-Yan and J/$\psi$ production is given by a universal function:\ $a+b q_T^2$, where parameters a and b are completely determined by either calculable quantities or independently measurable physical observables. We demonstrate that this universal function $\alpha(A,q_T)$ is insensitive to the A for normal nuclear targets. For a color deconfined nuclear medium, the $\alpha(A,q_T)$ becomes strongly dependent on the A. We also show that our $\alpha(A,q_T)$ for the Drell-Yan process is naturally linked to perturbatively calculated $\alpha(A,q_T)$ at large $q_T$ without any free parameters, and the $\alpha(A,q_T)$ is consistent with E772 data for all $q_T$.Comment: latex, 28 pages, 10 figures, updated two figures, and add more discussion

Signatures of Thermal Dilepton Radiation at RHIC

The properties of thermal dilepton production from heavy-ion collisions in the RHIC energy regime are evaluated for invariant masses ranging from 0.5 to 3 GeV. Using an expanding thermal fireball to model the evolution through both quark-gluon and hadronic phases various features of the spectra are addressed. In the low-mass region, due to an expected large background, the focus is on possible medium modifications of the narrow resonance structures from $\omega$ and $\phi$ mesons, whereas in the intermediate-mass region the old idea of identifying QGP radiation is reiterated including effects of chemical under-saturation in the early stages of central Au+Au collisions.Comment: 17 pages ReVTeX including 16 figure

SLM2 is a novel cardiac splicing factor involved in heart failure due to dilated cardiomyopathy

Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing is involved in the pathophysiology of heart failure. Mutations in the splicing factor RNA binding motif protein 20 (RBM20) cause severe forms of cardiomyopathy. To identify novel cardiomyopathy-associated splicing factors, RNA-seq and tissue-enrichment analysis were performed, which identified upregulation of Sam68-Like Mammalian Protein 2 (SLM2) in the left ventricle of dilated cardiomyopathy (DCM) patients. In the human heart, SLM2 binds to important transcripts of sarcomere constituents, such as myosin light chain 2 (MYL2), troponin I3 (TNNI3), troponin T2 (TNNT2), tropomyosin 1/2 (TPM1/2), and titin (TTN). Mechanistically, SLM2 mediates intron retention, prevents exon exclusion, and thereby mediates alternative splicing of the mRNA regions encoding the variable proline-, glutamate-, valine-, and lysine-rich (PEVK) domain and another part of the I-band region of titin. In summary, SLM2 is a novel cardiac splicing regulator with essential functions for maintaining cardiomyocyte integrity by binding and processing the mRNA of essential cardiac constituents such as titin

Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy

Aims: In this study, we aimed to clinically and genetically characterize LVNC patients and investigate the prevalence of variants in known and novel LVNC disease genes. Introduction: Left ventricular non-compaction cardiomyopathy (LVNC) is an increasingly recognized cause of heart failure, arrhythmia, thromboembolism, and sudden cardiac death. We sought here to dissect its genetic causes, phenotypic presentation and outcome. Methods and results: In our registry with follow-up of in the median 61 months, we analysed 95 LVNC patients (68 unrelated index patients and 27 affected relatives; definite familial LVNC = 23.5%) by cardiac phenotyping, molecular biomarkers and exome sequencing. Cardiovascular events were significantly more frequent in LVNC patients compared with an age-matched group of patients with non-ischaemic dilated cardiomyopathy (hazard ratio = 2.481, P = 0.002). Stringent genetic classification according to ACMG guidelines revealed that TTN, LMNA, and MYBPC3 are the most prevalent disease genes (13 patients are carrying a pathogenic truncating TTN variant, odds ratio = 40.7, Confidence interval = 21.6-76.6, P < 0.0001, percent spliced in 76-100%). We also identified novel candidate genes for LVNC. For RBM20, we were able to perform detailed familial, molecular and functional studies. We show that the novel variant p.R634L in the RS domain of RBM20 co-segregates with LVNC, leading to titin mis-splicing as revealed by RNA sequencing of heart tissue in mutation carriers, protein analysis, and functional splice-reporter assays. Conclusion: Our data demonstrate that the clinical course of symptomatic LVNC can be severe. The identified pathogenic variants and distribution of disease genes-a titin-related pathomechanism is found in every fourth patient-should be considered in genetic counselling of patients. Pathogenic variants in the nuclear proteins Lamin A/C and RBM20 were associated with worse outcome

Proton, deuteron and triton flow measurements in Au+Au collisions at sNN=2.4\sqrt{s_{NN}} = 2.4 GeV

High precision measurements of flow coefficients $v_{n}$ ($n = 1 - 4$) for protons, deuterons and tritons relative to the first-order spectator plane have been performed in Au+Au collisions at $\sqrt{s_{NN}} = 2.4$ GeV with the High-Acceptance Di-Electron Spectrometer (HADES) at the SIS18/GSI. Flow coefficients are studied as a function of transverse momentum $p_{t}$ and rapidity $y_{cm}$ over a large region of phase space and for several classes of collision centrality. A clear mass hierarchy is found for the slope of $v_{1}$, $d v_{1}/d y^{\prime}|_{y^{\prime} = 0}$ where $y^{\prime}$ is the scaled rapidity, and for $v_{2}$ at mid-rapidity. Scaling with the number of nucleons is observed for the $p_{t}$ dependence of $v_{2}$ and $v_{4}$ at mid-rapidity, which is indicative for nuclear coalescence as the main process responsible for light nuclei formation. $v_{2}$ is found to scale with the initial eccentricity $\langle \epsilon_{2} \rangle$, while $v_{4}$ scales with $\langle \epsilon_{2} \rangle^{2}$ and $\langle \epsilon_{4} \rangle$. The multi-differential high-precision data on $v_{1}$, $v_{2}$, $v_{3}$, and $v_{4}$ provides important constraints on the equation-of-state of compressed baryonic matter

Identical pion intensity interferometry in central Au + Au collisions at 1.23 A GeV

International audienceWe investigate identical pion HBT intensity interferometry in central Au + Au collisions at 1.23 A GeV. High-statistics π−π− and π+π+ data are measured with HADES at SIS18/GSI. The radius parameters, derived from the correlation function depending on relative momenta in the longitudinally comoving system and parametrized as three-dimensional Gaussian distribution, are studied as function of transverse momentum. A substantial charge-sign difference of the source radii is found, particularly pronounced at low transverse momentum. The extracted source parameters agree well with a smooth extrapolation of the center-of-mass energy dependence established at higher energies, extending the corresponding excitation functions down towards a very low energy

Time-Like Baryon Transitions studies with HADES

The HADES collaboration uses the e+e− production as a probe of the resonance matter produced in collisions at incident energies of 1-3.5 GeV/nucleon at GSI. Elementary reactions provide useful references for these studies and give information on resonance Dalitz decays (R→Ne+e−). Such processes are sensitive to the structure of time-like electromagnetic baryon transitions in a kinematic range where (off-shell) vector mesons play a crucial role. Results obtained in proton-proton reactions and in a commissioning pion-beam experiment are reported and prospects for future pion beam experiments and for first hyperon Dalitz decay measurements are described. The connection with the investigations of medium effects to be continued with HADES in the next years at SIS18 and SIS100 is also discussed