19 research outputs found
Nuclear dependence coefficient for the Drell-Yan and J/ production
Define the nuclear dependence coefficient in terms of ratio
of transverse momentum spectrum in hadron-nucleus and in hadron-nucleon
collisions: . We argue that in small region, the
for the Drell-Yan and J/ production is given by a universal function:\
, where parameters a and b are completely determined by either
calculable quantities or independently measurable physical observables. We
demonstrate that this universal function is insensitive to the
A for normal nuclear targets. For a color deconfined nuclear medium, the
becomes strongly dependent on the A. We also show that our
for the Drell-Yan process is naturally linked to perturbatively
calculated at large without any free parameters, and the
is consistent with E772 data for all .Comment: latex, 28 pages, 10 figures, updated two figures, and add more
discussion
Signatures of Thermal Dilepton Radiation at RHIC
The properties of thermal dilepton production from heavy-ion collisions in
the RHIC energy regime are evaluated for invariant masses ranging from 0.5 to 3
GeV. Using an expanding thermal fireball to model the evolution through both
quark-gluon and hadronic phases various features of the spectra are addressed.
In the low-mass region, due to an expected large background, the focus is on
possible medium modifications of the narrow resonance structures from
and mesons, whereas in the intermediate-mass region the old idea of
identifying QGP radiation is reiterated including effects of chemical
under-saturation in the early stages of central Au+Au collisions.Comment: 17 pages ReVTeX including 16 figure
SLM2 is a novel cardiac splicing factor involved in heart failure due to dilated cardiomyopathy
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing is involved in the pathophysiology of heart failure. Mutations in the splicing factor RNA binding motif protein 20 (RBM20) cause severe forms of cardiomyopathy. To identify novel cardiomyopathy-associated splicing factors, RNA-seq and tissue-enrichment analysis were performed, which identified upregulation of Sam68-Like Mammalian Protein 2 (SLM2) in the left ventricle of dilated cardiomyopathy (DCM) patients. In the human heart, SLM2 binds to important transcripts of sarcomere constituents, such as myosin light chain 2 (MYL2), troponin I3 (TNNI3), troponin T2 (TNNT2), tropomyosin 1/2 (TPM1/2), and titin (TTN). Mechanistically, SLM2 mediates intron retention, prevents exon exclusion, and thereby mediates alternative splicing of the mRNA regions encoding the variable proline-, glutamate-, valine-, and lysine-rich (PEVK) domain and another part of the I-band region of titin. In summary, SLM2 is a novel cardiac splicing regulator with essential functions for maintaining cardiomyocyte integrity by binding and processing the mRNA of essential cardiac constituents such as titin
Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy
Aims: In this study, we aimed to clinically and genetically characterize LVNC patients and investigate the prevalence of variants in known and novel LVNC disease genes. Introduction: Left ventricular non-compaction cardiomyopathy (LVNC) is an increasingly recognized cause of heart failure, arrhythmia, thromboembolism, and sudden cardiac death. We sought here to dissect its genetic causes, phenotypic presentation and outcome. Methods and results: In our registry with follow-up of in the median 61 months, we analysed 95 LVNC patients (68 unrelated index patients and 27 affected relatives; definite familial LVNC = 23.5%) by cardiac phenotyping, molecular biomarkers and exome sequencing. Cardiovascular events were significantly more frequent in LVNC patients compared with an age-matched group of patients with non-ischaemic dilated cardiomyopathy (hazard ratio = 2.481, P = 0.002). Stringent genetic classification according to ACMG guidelines revealed that TTN, LMNA, and MYBPC3 are the most prevalent disease genes (13 patients are carrying a pathogenic truncating TTN variant, odds ratio = 40.7, Confidence interval = 21.6-76.6, P < 0.0001, percent spliced in 76-100%). We also identified novel candidate genes for LVNC. For RBM20, we were able to perform detailed familial, molecular and functional studies. We show that the novel variant p.R634L in the RS domain of RBM20 co-segregates with LVNC, leading to titin mis-splicing as revealed by RNA sequencing of heart tissue in mutation carriers, protein analysis, and functional splice-reporter assays. Conclusion: Our data demonstrate that the clinical course of symptomatic LVNC can be severe. The identified pathogenic variants and distribution of disease genes-a titin-related pathomechanism is found in every fourth patient-should be considered in genetic counselling of patients. Pathogenic variants in the nuclear proteins Lamin A/C and RBM20 were associated with worse outcome
Proton, deuteron and triton flow measurements in Au+Au collisions at GeV
High precision measurements of flow coefficients () for protons, deuterons and tritons relative to the first-order spectator plane have been performed in Au+Au collisions at GeV with the High-Acceptance Di-Electron Spectrometer (HADES) at the SIS18/GSI. Flow coefficients are studied as a function of transverse momentum and rapidity over a large region of phase space and for several classes of collision centrality. A clear mass hierarchy is found for the slope of , where is the scaled rapidity, and for at mid-rapidity. Scaling with the number of nucleons is observed for the dependence of and at mid-rapidity, which is indicative for nuclear coalescence as the main process responsible for light nuclei formation. is found to scale with the initial eccentricity , while scales with and . The multi-differential high-precision data on , , , and provides important constraints on the equation-of-state of compressed baryonic matter
Identical pion intensity interferometry in central Au + Au collisions at 1.23 A GeV
International audienceWe investigate identical pion HBT intensity interferometry in central Au + Au collisions at 1.23 A GeV. High-statistics π−π− and π+π+ data are measured with HADES at SIS18/GSI. The radius parameters, derived from the correlation function depending on relative momenta in the longitudinally comoving system and parametrized as three-dimensional Gaussian distribution, are studied as function of transverse momentum. A substantial charge-sign difference of the source radii is found, particularly pronounced at low transverse momentum. The extracted source parameters agree well with a smooth extrapolation of the center-of-mass energy dependence established at higher energies, extending the corresponding excitation functions down towards a very low energy
Time-Like Baryon Transitions studies with HADES
The HADES collaboration uses the e+e− production as a probe of the resonance matter produced in collisions at incident energies of 1-3.5 GeV/nucleon at GSI. Elementary reactions provide useful references for these studies and give information on resonance Dalitz decays (R→Ne+e−). Such processes are sensitive to the structure of time-like electromagnetic baryon transitions in a kinematic range where (off-shell) vector mesons play a crucial role. Results obtained in proton-proton reactions and in a commissioning pion-beam experiment are reported and prospects for future pion beam experiments and for first hyperon Dalitz decay measurements are described. The connection with the investigations of medium effects to be continued with HADES in the next years at SIS18 and SIS100 is also discussed