The role of lipids in mechanosensation

Acknowledgements: This work was supported by Wellcome Trust grants WT092552MA (J.H.N. and I.R.B.), Senior Investigator Award WT100209MA (J.H.N.), 093228 (T.K.S.) and 092970 (M.S.P.S.), and Biotechnology and Biological Sciences Research Council grants BB/I019855/1 (M.S.P.S.), BB/H017917/1 (J.H.N. and I.R.B.) and BB/J009784/1 (H.B.). We acknowledge the Diamond Light Source for beam time. I.R.B. is supported as a Leverhulme Emeritus Fellow. J.H.N. is supported as a Royal Society Wolfson Merit Award holder and as a 1000 Talent Scholar at Sichuan University. A.C.E.D. was supported by an Engineering and Physical Sciences Research Council Systems Biology Doctoral Training Centre student fellowship. We thank R. Phillips, A. Lee and S. Conway for helpful discussions.Peer reviewedPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprintPostprin

Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets

The authors are grateful to Tony Lee (Southampton) and Jim Naismith (St Andrews and Oxford) for helpful discussions. IRB, SM, AR, TR, SB were supported by a Wellcome Programme Grant (WT092552MA); HG and CK were funded by the EU FP7 ITN programme NICHE. The MscS F151W mutant was created by N. J. Hayward during his PhD studies at the University of Aberdeen. We thank Vanessa Flegler for assistance in the electron microscopy experiment. IRB was a recipient of a Leverhulme Emeritus Research Fellowship and a CEMI research grant from Caltech; PB was supported by Grant I-1420 of the Welch Foundation and Grant GM121780 from the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or other funding organizations.Peer reviewedPublisher PD