Studies on Antimicrobial Evaluation of Some 1-((1-(1<i>H</i>-Benzo[<i>d</i>]imidazol-2-yl)ethylidene)amino)-6-((arylidene)amino)-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles

<div><p></p><p>A new series of 1-((1-(1<i>H</i>-benzo[<i>d</i>]imidazol-2-yl)ethylidene)amino)-6-((arylidene)amino)-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles <b>(4a–o)</b> have been synthesized for the development of antimicrobial agents. Newly synthesized compounds were evaluated for their in vitro antibacterial activity against Gram-positive bacteria (<i>Pseudomonas aeruginosa</i>, <i>Streptococcus pyogenes</i>), Gram-negative bacteria (<i>Escherichia coli</i>, <i>Staphylococcus aureus</i>), and antifungal activity (<i>Candida albicans</i>, <i>Aspergillus niger</i>, <i>Aspergillus clavatus</i>). These compounds were characterized by infrared, ¹H NMR, ¹³C NMR, and mass spectra. The synthesized compounds <b>4b, 4e, 4 h,</b> and <b>4k</b> showed potent antimicrobial activity against tested microorganisms.</p></div

"HIT on Trousseau" double trouble: acquired coagulopathy with femoral artery thrombosis

Trousseau Syndrome is a paraneoplastic procoagulant phenomenon. Heparin-induced thrombocytopenia (HIT) is a rare complication of anticoagulation with heparin. To our knowledge, the coincidence of the two has not been reported so far. We report a case of an acute thrombosis of the left femoral artery and distal leg arteries in a patient with an otherwise normal cardiovascular status. Endovascular revascularization attempts using mechanical rotational thrombectomy catheter, aspiration and local thrombolysis were unsuccessful. Progressive coagulation along the intra-arterial catheter was seen. Surgical thrombectomy of the femoral-pedal axis was successful, but the patient developed an immune-mediated HIT postoperatively. An adenocarcinoma of the colon was the likely cause for the initial arterial thrombosis, and probably adversely affected endovascular revascularization attempts. Subsequent HIT with microvascular thrombosis worsened ischemic damage leading to a below knee-amputation, despite patent large vessels. Compared to venous thrombosis, arterial thrombosis is a rare manifestation of Trousseau syndrome. The coincidence of it with HIT is even rarer. There may be a causal relationship between the two

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<div>Dataset associated with Nature Medicine (2016), doi:10.1038/nm.4106</div><div><br></div><div>Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor</div><div><br></div><div>1. RNA-Sequencing data of astrocytes during late stage Experimental autoimmune encephalomyelitis (EAE experiments) as compared to naive mice</div><div><br></div><div>2. Nanostring data of astrocytes and microglia during EAE</div><div><br></div><div><br></div