Plasmodium falciparum proteinases: cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase

Numerous proteinase activities have been shown to be essential for the survival of Plasmodium falciparum. One approach to antimalarial chemotherapy, would be to block specifically one or several of these activities, by using compounds structurally analogous to the substrates of these proteinases. Such a strategy requires a detailed knowledge of the active site of the proteinase, in order to identify the best substrate for the proteinase. Aiming at developing such a strategy, two proteinases previously identified in our laboratory, were chosen for further characterization of their molecular structure and properties: the merozoite proteinase for erythrocytic invasion (MPEI), involved in the erythrocyte invasion by the merozoites, and the Pf37 proteinase, which hydrolyses human spectrin in vitro

Diffractive structures in the THz frequency range: the new solution to fight counterfeiting

International audienc

THID : une technique nouvelle pour l’identification des produits dans le domaine THz

National audienc

Identifying and understanding gait deviations: critical review and perspectives

Walking is paramount in the activities of the daily life of the human being and can be altered in neuro-musculoskeletal disorders. It is therefore essential to identify and better understand abnormal gait patterns linked to these disorders and to treat them. Clinical gait analysis (CGA) is a medical examination that objectively identifies gait deviations. CGA includes video recordings, spatiotemporal parameters, kinematics, kinetics and electromyography of a patient's gait. The objective of this article is to critically review conventional methods to identify gait deviations and methods used to improve understanding of gait deviations. After addressing conventional CGA, this article provides new avenues to better identify gait deviations based on existing literature. Different approaches to improve the understanding of gait deviations are presented. They are based on pathological models, experimental procedures, numerical simulations, anthropomorphic robots and animal models

Beyond RF: the terahertz radiation and its applications

National audienc

Beyond RF: the terahertz radiation and its applications

National audienc

Diffraction grating tags structures dedicated to authentication in the THz

International audienceIn this paper, we report on the statistical analysis of the THz signatures of identically realized diffraction grating-based tags by repeatable measurements. The correlation between the different signatures is analysed and the global error rates are evaluated from the statistical distributions and we show that error rates of 2.75% can be reached

Potential of chipless authentication based on randomness inherent in fabrication process for RF and THz

International audienceIn this paper, two chipless solutions dedicated to the authentication of manufactured products are proposed. One device is operating in the RF domain while the other used terahertz (THz) waves. The concept of chipless RFID is extended to authentication where each tag has to present a unique signature that can never be reproduced even if someone try to copy the tag. Both approaches use Electromagnetic (EM) wave as a tool for non-invasive and non-destructive authentication of items. The results show that it is possible to discriminate RF, respectively THz, signatures obtained from devices whose differences of geometrical parameters are as small as tens of micrometers, respectively several micrometers in the THz domain

Authentication in the THz domain: a new tool to fight couterfeiting

International audienceIntroduction: In the present work, we propose a new approach based on the use of the spectral signature of diffraction gratings engraved on one side of smart cards to be authenticated. The etched substrate acts as a dielectric waveguide associated to a 1D diffraction grating [1]. When the coupling conditions are verified, the reflected and transmitted THz spectra exhibit extinction lines (m-lines) that can be used as a broadband and rich spectral signature. For a given incident angle, the number of m-lines, their frequency positions and depth depend on the geometrical dimensions of the structure [2]. Hence, a unique etching scheme leads to a unique spectral signature. We first focused on simulations and experimental validation of the proposed authentication method that we would present to the 9 th THz days