11 research outputs found
The role of cadherin/catenin complex in malignant melanoma
In the present review article the role of cadherin/catenin complex in cases of malignant melanoma is discussed in some detail. Cadherins represent the most important superfamily of adhesion molecules with epithelial E-cadherin being the most studied. Its role in normal state as well as in cancer invasion and metastasis and some other pathologies is crucial. E-cadherin expression is altered in malignant melanomas and its downregulation or absence is associated with melanoma invasion and metastasis potential. A shift from E-cadherin expression to neural N-cadherin expression in melanocytes is also detected in malignant melanomas formation. In addition, a discussion regarding the role of placental P-cadherin and vascular endothelial VE-cadherin as well as the recently identified molecule of dysadherin, is attempted in brief.Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ ΡΠΎΠ»Ρ ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½/ΠΊΠ°ΡΠ΅Π½ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΏΡΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΠ΅. ΠΠ°Π΄Π³Π΅ΡΠΈΠ½Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ
ΡΠΎΠ±ΠΎΠΉ ΡΡΠΏΠ΅ΡΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²ΠΎ Π°Π΄Π³Π΅Π·ΠΈΠ²Π½ΡΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ», ΡΡΠ΅Π΄ΠΈ ΠΊΠΎΡΠΎΡΡΡ
Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΈΠ·ΡΡΠ΅Π½ ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΠΉ ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½ (E-ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½), Π²ΡΠΏΠΎΠ»Π½ΡΡΡΠΈΠΉ
ΠΊΠ»ΡΡΠ΅Π²ΡΡ ΡΠΎΠ»Ρ Π² Π½ΠΎΡΠΌΠ΅ ΠΈ ΠΏΡΠΈ ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠΌ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΌ ΡΠΎΡΡΠ΅ ΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ. Π ΡΠΊΠ°Π½ΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΌΠ΅Π»Π°Π½ΠΎΠΌ
ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ E-ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½, Π΅Π³ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΈΠ»ΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΠΌ ΡΠΎΡΡΠΎΠΌ ΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ
ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ. ΠΡΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΌΠ΅Π»Π°Π½ΠΎΠΌ Π² ΠΌΠ΅Π»Π°Π½ΠΎΡΠΈΡΠ°Ρ
ΠΎΡΠΌΠ΅ΡΠ°ΡΡ Π·Π°ΠΌΠ΅Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ E-ΠΊΠ°Π΄Π΅ΡΠΈΠ½Π° Π½Π° ΡΠ°ΠΊΠΎΠ²ΡΡ
Π½Π΅Π²ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½Π° (N-ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½Π°). ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΊΠΎΡΠΎΡΠΊΠΎ ΠΎΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ ΡΠΎΠ»Ρ ΠΏΠ»Π°ΡΠ΅Π½ΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½Π° (P-ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½Π°),
ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½Π° ΡΠΎΡΡΠ΄ΠΎΠ² (VE-ΠΊΠ°Π΄Π΅ΡΠΈΠ½Π°) ΠΈ Π½Π΅Π΄Π°Π²Π½ΠΎ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄ΠΈΡΠ°Π΄Π³Π΅ΡΠΈΠ½Π°
The role of intercellular adhesion molecule-1 in head and neck cancer
The intercellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin gene superfamily of adhesion molecules expressed in multiple human tissues and participating in various physiologic and pathophysiologic processes of the human body. The alterations in the expression of ICAM-1 in the various types of the cancer of the head and neck are discussed in this mini-review following the existing status from the current literature. Possible applications of this developing knowledge in the diagnosis and prognosis of head and neck cancer are briefly mentioned.ΠΠΎΠ»Π΅ΠΊΡΠ»Ρ ΠΌΠ΅ΠΆΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π°Π΄Π³Π΅Π·ΠΈΠΈ (ICAM-1), ΡΠ²Π»ΡΡΡΠΈΠ΅ΡΡ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠΌ Π³Π΅Π½Π° β ΡΠ»Π΅Π½Π° ΡΡΠΏΠ΅ΡΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° Π³Π΅Π½ΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠ², ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Ρ Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ
ΠΌΠ½ΠΎΠ³ΠΈΡ
ΡΠΊΠ°Π½Π΅ΠΉ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΏΡΠΈΠ½ΠΈΠΌΠ°ΡΡ ΡΡΠ°ΡΡΠΈΠ΅ Π² ΡΡΠ΄Π΅ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΏΠ°ΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ². Π ΠΌΠΈΠ½ΠΈ-ΠΎΠ±Π·ΠΎΡΠ΅ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½Ρ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π΄Π°Π½Π½ΡΠ΅ Π΄ΠΎΡΡΡΠΏΠ½ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡ ΡΡ ΠΎΠ± ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΈ ΡΡΠΎΠ²Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ IG4M-1 ΠΏΡΠΈ ΡΠ°ΠΊΠ΅ Π³ΠΎΠ»ΠΎΠ²Ρ ΠΈ ΡΠ΅ΠΈ. Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π·Π½Π°Π½ΠΈΠΉ ΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π°Ρ
Π°Π΄Π³Π΅Π·ΠΈΠΈ Π² ΠΎΠ±Π»Π°ΡΡΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ
Which Health-Related Quality of Life Items Most Affect Acne Patients?
BACKGROUND: Health-related quality of life (HRQoL) assessment in patients with acne is recommended by several national guidelines. There are several acne-specific HRQoL instruments. OBJECTIVES: Participants of the European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on QoL and Patient Oriented Outcomes (PO) and Acne, Rosacea, and Hidradenitis Suppurativa (ARHS) agreed to scrutinize aspects of existing acne-specific HRQoL instruments for their relevance in international study. METHODS: Consensus agreement on items related to QoL was reached after an independent assessment by seven experts from the EADV TFs on QoL and PO, and a list of 97 items was prepared and proposed to a group of acne patients. In order to have data from patients to check if any important topics were overseen, another group of acne patients from participating countries was asked to list how acne influenced different aspects of their lives. RESULTS: Based on results obtained from 601 acne patients from nine countries, most of the items and topics showed low relevance for acne patients especially during the previous month or shorter time periods. Based on percentage of relevance and factor analysis, short (6 items) and long (45 items) lists of the most relevant topics were formed. CONCLUSION: Most of the items and topics from the initial list showed low relevance for acne patients. None of the identified acne-specific HRQoL instruments contain all the items that were deemed most relevant to acne patients. For this reason, participating members of the EADV TFs on QoL and PO, and ARHs are in the process of developing a new acne-specific HRQoL instrument
Not so simple: the complexity of phosphotyrosine signaling at cadherin adhesive contacts
Cadherin cell-cell adhesion critically determines tissue organization and integrity in many organs of the body. Cadherin function influences patterning and morphogenesis while cadherin dysfunction contributes to disease, notably tumor invasion and metastasis. Cell signaling events are intimately linked with cadherin function; it is increasingly apparent that not only do cellular signals regulate cadherin function, but cadherins can also, in turn, modulate cell signaling itself. In this review, we discuss the complex interrelationship between phosphotyrosine-based cell signaling and cadherin adhesion. We focus on the interplay of events that occur at the cell surface and address three issues: the diverse mechanisms that activate phosphotyrosine signaling at cadherin cell-cell contacts, the functional impact of such signaling for cadherin adhesion, and the emerging capacity for cadherins to regulate growth factor signaling