3 research outputs found
Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts
We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results
Izloženost živi i funkcija Ŕtitaste žlezde: postoji li veza?
Mercury (Hg) is one of the most important environmental pollutants with endocrine-
disrupting properties. There is little data from epidemiological studies describing the dose-
response relationship between toxic metal levels and hormone levels. The aim of this study was
to use the nearest neighbor matching analysis to determine the difference in Hg concentration in
healthy/sick subjects with thyroid disease and to use Benchmark modeling to determine the dose-
response relationship between Hg levels in the blood and thyroid-stimulating hormone (TSH) and
thyroid hormones in serum. Blood samples were collected and used for Hg measurement using
the ICP-MS method, and separated serum was used for hormone analysis. The study showed the
existence of a statistically significant difference in Hg levels measured in healthy and sick subjects
and the existence of a dose-response relationship between Hg and all measured hormones, with a
narrow interval obtained for the Hg-TSH pair. The results of this research support the use of the
Benchmark dose approach for the purpose of analyzing data from human studies, and our further
research will be focused on examining the impact of low doses on animal models in order to
determine more precise effects of low doses on the organism.Živa (Hg) je jedan od najznaÄajnijih zagaÄivaÄa životne sredine sa osobinama endokrinog ometaÄa. Malo je podataka iz epidemioloÅ”kih studija koji opisuju odnos doza-odgovor izmeÄu nivoa toksiÄnih metala i nivoa hormona. Cilj ovog rada bio je da primenom nearest neighbor matching analize utvrdi razliku u koncentraciji Hg kod zdravih/obolelih ispitanika od bolesti Å”titaste žlezde i da primenom Benchmark modelovanja utvrdi odnos doza-odgovor izmeÄu nivoa Hg u krvi i tireostimuliÅ”uÄeg hormona (TSH) i tiroidnih hormona u serumu. Uzorci krvi su sakupljeni i koriÅ”Äeni za merenje Hg uz pomoÄ ICP-MS metode, a izdvojeni serum koriÅ”Äen je za analizu hormona. Studija je pokazala postojanje statistiÄki znaÄajne razlike u nivoima Hg koji su izmereni kod zdravih i bolesnih ispitanika i postojanje odnosa doza-odgovor izmeÄu Hg i svih merenih hormona, pri Äemu je uzak interval dobijen za Hg-TSH par. Rezultati ovog istraživanja podržavaju upotrebu Benchmark dose pristupa u svrhu analize podataka iz humanih studija, a naÅ”a dalja istraživanja Äe biti usmerena na ispitivanje uticaja niskih doza na životinjskim modelima, u cilju utvrÄivanja preciznijih efekata niskih doza na organizam
Informed mom, healthy baby - How to live safely with chemicals
Poslednjih decenija proÅ”log veka nauÄnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati Å”tetne efekte po naÅ”e zdravlje. MeÄu hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ...In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ..