Some aspects of the latent iron deficiency diagnosis in the patients with cardiac pathology

Currently, anemia (AN) is a common chronic disease. According to WHO (2008) 24.8% of the world population is at risk of developing anemia. One of the most important causes of anemia is iron deficiency [5]. Anemia is an independent risk factor for adverse cardiovascular disease (CVD) outcomes [6]. It’s shown that anemia contributes to the manifestation of coronary heart disease (CHD) [3], worsens the prognosis and development of complications in acute myocardial infarction [4], and increases the risk of heart failure progression [2]. In cardiac patients, the leading factors of anemia etiology and pathogenesis are associated chronic diseases (infections, chronic inflammatory diseases, neoplasm, chronic renal failure) (about 58%) and iron deficiency (about 21%) [1]. In the both cases, the diagnosis and correction of iron deficiency are the main factors to combat this disease. The purpose of the study: to analyze the prevalence of indirect signs of latent iron deficiency in patients with CVD. Materials and methods: 100 patients with the most common cardiovascular diseases (stable forms of CHD and Hypertension (AH)) were examined during the planned treatment in the cardiology department of DCCH # 9

Methodological approaches to the teaching of Endocrinology to the ctudents of the 4th course: from the interrelation of the components to problematic issues

The article by Tyshchenko I.V. and Bondareva O.O. “Methodological approaches to teaching endocrinology to fourth-year students: from interrelation of components to problematic issues” represents the peculiarities of studying endocrinology by fourth-year students in the „Medicine” specialty. The focus is on the integrative approach to teaching Endocrinology as an important part of discipline „Internal Medicine”. The article touches upon the complexity, specifity and continuity of the educational process in higher medical school, the step-by-step training of doctor. It demonstrates the interrelation of different components of the educational process (lectures, practical classes and self-studying) and their importance to the effectiveness of learning, the impact of additional events, such as participation in department’s „students’ study group” or in the academical endocrinology contest, to raise students’ interest in the study of the subject. The work also analyses various issues which both students and teachers face within the educational process. The article emphasizes the value of implementing modern approaches and contemporary technologies of studying for deeper consolidation of the acquired physician knowledge and practical skills, particularly in endocrinology. У статті Тищенко І.В., Бондаревої О.О. «Методологічні підходи до викладання ендокринології студентам 4 курсу: від взаємозв’язку складових до проблемних питань» висвітлено особливості вивчення питань ендокринології студентами 4 курсу за спеціальністю «Медицина». Зроблено наголос на інтегративному підході викладання ендокринології як однієї з важливих частин дисципліни «Внутрішня медицина». Обговорено комплексність, специфічність та безперервність освітнього процесу в вищій медичній школі, поетапність підготовки лікаря. Показано взаємозв’язок різних складових освітнього процесу (лекції, практичні заняття, самостійна підготовка) та їх значення для ефективності навчання, роль додаткових заходів, таких, як участь у роботі студентського наукового гуртка кафедри та змагання під час предметної олімпіади з ендокринології, для підвищення зацікавленості студентів щодо вивчення предмета. Проаналізовано низку проблем, які постають під час навчання як перед викладачами, так і перед студентами. Підкреслено значення впровадження новітніх поглядів на освітній процес та сучасних технологій навчання для глибокого закріплення отриманих знань та практичних навичок лікаря, зокрема, з ендокринології

Construction features of scoring models based on DEDUCTOR analytical platform

The aim of the study is to build a scoring model based on Deductor analytical platform. Problems solved by this method are introduced to actualizing the research. The source data for customer response prediction is the scoring profile of the OTP Bank. Modeling process and Fine&Coarse Classing Deductor’s handler are described. Fine&Coarse Classing is capable of reducing the unique values and allows to analyze iteratively and to improve the quality and speed of model building. The weight of evidence, information value and the value of the objective function enable the fundamental parameters to be determined from experimental results. The conclusion is made that using Deductor have several advantages over manual calculations

The use of antihomotoxic medications for treatment feline urological syndrome

Urolithiasis is one of the most common disorders of the urinary tract. It can cause Feline Urological Syndrome (FUS). Application of an ordinary therapeutic approach can be ineffective or demand very toxic preparations. On the other hand antihomotoxics cut down the time and negative aftereffects of the treatment.Purpose: To analyze Berberis vulgaris, the main homeopathic substance commonly used to treat FUS. The study focuses on demonstration the sensible combined use of allopathy and homeopathy.Methodology: B. vulgaris was tested on 24 Wistar rats with urolithiasis symptoms.Resalts: The use of B. vulgaris idecreased the uroliths' formation.Conclusion: B. vulgaris has strong potential in FUS treatment

Анемия возрастных лошадей

Anemia occurs in horses of any age, but is especially often diagnosed already in old age. Not surprisingly, the list of possible reasons for them is also greater. It is important to understand that in the case of horses, iron deficiency in the diet is not the likely cause of the disease, and adding it to the feed will not contribute to the production of red blood cells. Immune-mediated conditions, blood clots, as well as a decrease in production, which may be associated with diseases of the bone marrow, kidney diseases, etc. [3].Анемия встречается у лошадей любого возраста, но особенно часто диагностируется уже в пожилом возрасте. Неудивительно, что список возможных причин для них тоже больше. Недостаток железа в рационе не является вероятной причиной заболевания, а его добавление в корма не будет способствовать выработке эритроцитов. Анемия может быть вызвана многими различными причинами, которые могут включать в себя увеличение разрушения эритроцитов из-за инфекции, иммуноопосредованных состояний, сгустков крови, а также снижение продукции, которое может быть связано с заболеваниями костного мозга, заболеваниями почек и т.д. [3, 4]

EQUINE INFECTIOUS ANEMIA: LATEST METHODS OF DIAGNOSTIC

Anemia occurs in horses of any age, it is not surprising that the list of possible causes, which may include an increase in red blood cell destruction, is quite high: infections, immune-mediated conditions, blood clots as well as a decrease in red blood cell production, which may be due to bone marrow diseases, kidney disease, etc. Equine infectious anemia (EIA) is a viral disease of members of the horse family, caused by an RNA-containing virus from the Lentivirus subfamily Retroviridae. It is accompanied by lesions of the blood-forming organs and is manifested by recurrent or persistent fever, anemia, and a disorder in the cardiovascular system. EIA still stands among the most important theoretical and practical problems of veterinary virology. Over the past few years, epizootic cases have been observed in the territory of the European Union (Germany, Poland, France 2015; Greece, Slovakia 2016; Germany 2017), the Russian Federation (Kemerovo Oblast, Pushkinsky District of St. Petersburg 2018), etc. Modern diagnostics EIA, represented by various serological and molecular genetic methods the only reliable way to control the disease

Diagnosis of the nutritional value of colostrum in cows of different milk yield

When forming in an organism of a newborn calf of tentative immunity, the main source of immunoglobulins, a lysozyme, the functionally active leukocytes and lymphocytes, a colostrum is. The quality of a colostrum is a very important condition for formation of full-fledged immunity. A number of scientists claim that cows of different lactic breeds considerably differ on the level of lactic efficiency, at the same time the mass fraction of immunoglobulins negatively correlates with amount of colostrum at the first milking. Studying of dynamics of quality of a colostrum depending on the size of a milk yielding of cows for a lactation was a primal problem of researches. As an object of researches served the cows of four breeds divorced in the Samara region: Black Pied breeds, Bestuzhev, Holstein and Ayrshire. It is established that the content of immunoglobulins in a colostrum of the first yield of milk at cows of different breeds changes under the influence of the level of lactic efficiency and also with the animals' age. The highest content of immunoglobulins was in a colostrum of Bestuzhev breed – 103.35-81.38 g/l, and the lowest at Holstein breed – 74.52-42.29 g/l. Immunoglobulins of a colostrum are divided into three classes – IgG, IgA, IGM. In a colostrum of the first milk yielding of cows of Black Pied breed the share of IgG makes 84.1-85.5%, Bestuzhev breed – 85.7-86.3%, Holstein – 83.9-84.4%, Ayrshire – 85.7-86.6%. The tendency of increase in a share of IgG, in process of increase in milk yields of cows for a lactation is noted. It is established that at increase in level of lactic efficiency of cows, the quality of a colostrum decreases and the number of incidence of calves increases. As a result, the size of average daily gain of young growth live weight proportionally decreases. On the basis of the received results we recommend to estimate quality of a colostrum of the first milk yield by means of an optical or digital refractometer. Carry out the targeted selection work with breeds in the direction of colostrum upgrading

Left ventricular myocardial remodeling in dogs with mitral valve endocardiosis

Background and Aim: Left ventricular myocardial remodeling could play an important role in the progression of chronic heart failure (CHF) syndrome in dogs with mitral valve endocardiosis. The aim of this study was to evaluate the left ventricular myocardial remodeling in dogs with mitral valve endocardiosis and to study the dependence of the incidence of this pathological phenomenon on the functional class (FC) of progression of the CHF syndrome. Materials and Methods: A total of 108 afflicted dogs and 36 clinically healthy dogs were examined using transthoracic echocardiography. The following structural and geometric parameters of the left ventricular remodeling were evaluated: Myocardial mass and its index, sphericity index at the end of systole and diastole, end-systolic and end-diastolic relative wall thickness, and integral remodeling index. Results: In all clinically healthy dogs, a normal type of the left ventricular chamber geometry was revealed, whereas, in dogs with mitral valve endocardiosis, the normal geometry of the left ventricle occurred in 56.4%, eccentric hypertrophy in 24.1%, concentric remodeling in 10.2%, and concentric hypertrophy in 9.3% of the cases. In patients with endocardiosis, there was no dilatation type of cardiac remodeling observed. Conclusion: When compared to the clinically healthy animals, the dogs with mitral valve endocardiosis presented with indicators of structural and geometric remodeling, such as increased myocardial mass, myocardial mass index, and sphericity index at the end of systole and diastole, as well as relatively reduced integral systolic index of remodeling and systolic relative thickness of the walls of the heart. The parameters of the left ventricular myocardial remodeling correlated significantly with the FC of CHF syndrome. © Vatnikov, et al. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated

The effects of meldonium on microrheological abnormalities of erythrocytes in rats with obesity: An experimental study

Background: The microrheological disorders of red blood cells in obesity is often missed by the researchers. This study aimed to report an experimental investigation on laboratory animals with developed obesity and to find out the effect of meldonium on the erythrocytes. Methods: A total of 95 healthy male-rats of Vistar line were taken into the investigation, 29 animals had experienced no impacts and allocated as the control group, while 64 rats which had developed obesity induced by a cardioangionefopathogenic semisynthetic diet into the obesity group. These rats were casually divided into an experimental (34 rats) group and the control group (30 rats). The rats of the experimental group in the next ten days were intragastrically injected with meldonium for 80 mg/kg. The biochemical, hematological and statistical methods of investigation were used in this study. Results: During the formation of obesity and the use of meldonium, the body weight of the rats were gradually decreased to the normal level. On the obese rat’s group receiving meldonium, the content of the lipids peroxidation products in erythrocytes progressively decreased. and reached the level of the healthy control rats group. Moreover, there was a decrease in the number of erythrocytes-discocytes accompanied by an increase in the reversible and irreversible changes. These values were returned to the level of the healthy control rats group at the end of the observation. This pattern was observed in the total number of erythrocytes aggregate and free erythrocytes. Conclusion: The application of meldonium eliminates the existing erythrocytes abnormal microrheological features in the rats with recently developed obesity. © 2020, Sanglah General Hospital. All rights reserved