Modification of NIROS for Hemodynamic Imaging of Large Wounds

A near-infrared optical scanner (NIROS) has been developed for non-contact sub-surface imaging of wounds. The current device, NIROS, employs a light source system of different wavelengths to image the same region during diabetic foot imaging studies. However, the illumination region by the system had produced small area of illumination and weak signal intensity, limiting the extraction of oxy- (HbO) and deoxy-hemoglobin (HbR) signals from entire areas of the wound and peri-wound. Herein, the source system of NIROS was modified to assess the changes in blood flow, in terms of changes in HbO and HbR, with maximum illumination between the different regions and increased intensity of illumination. The modified NIROS will allow imaging of larger wounds (\u3e 8cm radius), such as venous leg ulcers and post-amputated diabetic foot ulcers, without adding to the patient time

Engineering DNA-grafted quatsomes as stable nucleic acid-responsive fluorescent nanovesicles

The development of artificial vesicles into responsive architectures capable of sensing the biological environment and simultaneously signaling the presence of a specific target molecule is a key challenge in a range of biomedical applications from drug delivery to diagnostic tools. Herein, the rational design of biomimetic DNA-grafted quatsome (QS) nanovesicles capable of translating the binding of a target molecule to amphiphilic DNA probes into an optical output is presented. QSs are synthetic lipid-based nanovesicles able to confine multiple organic dyes at the nanoscale, resulting in ultra-bright soft materials with attractiveness for sensing applications. Dye-loaded QS nanovesicles of different composition and surface charge are grafted with fluorescent amphiphilic nucleic acid-based probes to produce programmable FRET-active nanovesicles that operate as highly sensitive signal transducers. The photophysical properties of the DNA-grafted nanovesicles are characterized and the highly selective, ratiometric detection of clinically relevant microRNAs with sensitivity in the low nanomolar range are demonstrated. The potential applications of responsive QS nanovesicles for biosensing applications but also as functional nanodevices for targeted biomedical applications is envisaged

Crustal structure beneath Spain from deep seismic sounding experiments

Major tectonic units of Spain have been investigated by deep seismic sounding experiments since 1974 to determine crustal structures and to delineate their differences. These areas are the central part of the Hercynian Meseta, and the Alpine chains: the Betic Cordillera in the south, including the Balearic promontory and the Alboran Sea, and the Pyrenees in the north. The main features of the crust and the upper mantle along a NNE-SSW cross-section from the Pyrenees to the Alboran Sea are described. The crust under the Meseta is typical of Hercynian areas found elsewhere in Europe, with an average thickness of 31 km, whereas the two Alpine regions are characterized by very large lateral inhomogeneities, such as rapid thickening of the crust to 50 and 40 km under the Pyrenees and the Betics, respectively. The deep-reaching E-W-trending North Pyrenean fault has a throw of 10-15 km at the base of the crust. A Pn velocity of 8.1 km s-1 is found under the entire Iberian Peninsula. In the Alboran Sea, strongly varying thicknesses of sediments, shallow variable depths to the Moho (∼ 13 km under the Alboran ridge), and strong variations of Pn velocity between 7.5 and 8.2 km s-1 have been found. © 1983.Peer Reviewe

Los secretos del profesorado eficaz en Educación Física

Resumen basado en el de la publicaciónSe pretenden mostrar los secretos del profesorado eficaz de Educación Física, mediante las contestaciones libres y personales de siete profesores y profesoras expertos sobre cuestiones relacionadas con la enseñanza en sus respectivos institutos. La orientación general de la Educación Física, la programación y la evaluación, son los apartados en los que, desde un punto de vista didáctico y formal, los autores hacen más aportaciones a la planificación docente. Ofrecen un abanico de propuestas muy útiles para planificar el curso y construir y temporalizar las unidades didácticas.CataluñaBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]