Twelfth Night by William Shakespeare and Anatomy of a Suicide by Alice Birch

Critique théâtrale, Juin/Juillet 2017 Spectacles : Twelfth Night de William Shakespeare—Globe Theatre (London), 18 mai, 2017- 5 août, 2017 ; Anatomy of a Suicide by Alice Birch—Royal Court Theatre Jerwood Theatre Downstairs (London), 3 juin, 2017- 8 juillet 2017.Theatre reviews, June/July 2017Show : Twelfth Night by William Shakespeare—Globe Theatre (London), May 18th, 2017- August 5th, 2017 ; Anatomy of a Suicide by Alice Birch—Royal Court Theatre Jerwood Theatre Downstairs (London), June 3rd, 2017-July 8th, 2017

Linda by Penelope Skinner and The Wasp by Morgan Lloyd Malcolm

Critique théâtrale, January 2016 Spectacles : Linda de Penelope Skinner—Royal Court Theatre (Londres), 29 novembre 2015-9 janvier, 2016 ; The Wasp de Morgan Lloyd Malcolm—Trafalgar Studios (Londres), décembre 2015-9 janvier 2016.Theatre reviews, January 2016Shows : Linda by Penelope Skinner—Royal Court Theatre (London), November, 29th, 2015- January, 9th, 2016 ; The Wasp by Morgan Lloyd Malcolm—Trafalgar Studios (London), December, 2015-January, 9th, 2016

The Cane by Mark Ravenhill and A Very Very Very Dark Matter by Martin McDonagh

Critiques théâtrale de The Cane by Mark Ravenhil, directed by Vicky Featherstone (6 December 2018–26 January 2019, Royal Court Jerwood Theatre Downstairs–London) et A Very Very Very Dark Matter by Martin McDonagh directed by Matthew Dunster (12 October 2018-6 January 2019, The Bridge Theatre–London).Theatre reviews of The Cane by Mark Ravenhil, directed by Vicky Featherstone (6 December 2018–26 January 2019, Royal Court Jerwood Theatre Downstairs–London) and A Very Very Very Dark Matter by Martin McDonagh directed by Matthew Dunster (12 October 2018-6 January 2019, The Bridge Theatre–London)

The Snapper by Roddy Doyle and Alys, Always by Lucinda Coxon

Critiques de la pièce The Snapper de Roddy Doyle (adaptée de son roman), mise en scène de Róisín McBrinn (6 juin 2019 – 24 août 2019, The Gate Theatre – Dublin) et Alys, Always de Lucinda Coxon (adapté du roman d’Harriet Lane), mise en scène de Nicholas Hytner (25 février 2019 – 30 mars 2019, The Bridge Theatre – Londres).Theatre reviews of The Snapper by Roddy Doyle (adapted from his novel), directed by Róisín McBrinn (6 June 2019–24 August 2019, The Gate Theatre—Dublin) and Alys, Always by Lucinda Coxon (adapted from Harriet Lane’s novel), directed by Nicholas Hytner (25 February 2019--30 March 2019, The Bridge Theatre–London)

Mapping the medical outcomes study HIV health survey (MOS-HIV) to the EuroQoL 5 Dimension (EQ-5D-3L) utility index

10.1186/s12955-019-1135-8Health and Quality of Life Outcomes1718

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD–abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system's integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Performance reviews of Linda by Penelope Skinner and The Wasp by Morgan Lloyd Malcolm

Theatre reviews, January 2016Shows : Linda by Penelope Skinner—Royal Court Theatre (London), November, 29th, 2015- January, 9th, 2016 ; The Wasp by Morgan Lloyd Malcolm—Trafalgar Studios (London), December, 2015-January, 9th, 2016