2 research outputs found
Computational analysis of clinical and molecular markers and new theranostic possibilities in primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is a paramount cause of irreversible visual
disability worldwide. We focus on identifying clinical and molecular facts that may help
elucidating the pathogenic mechanisms of the disease. By using ophthalmological approaches
(biomicroscopy, ocular fundus, optical coherence tomography, and perimetry) and experimental
tests (enzyme-linked immunosorbent assay (ELISA), high performance liquid chromatography
(HPLC), and Western blot/immunoblotting) directed to evaluate the oxidative stress, inflammation,
apoptosis, and neurodegeneration processes, we gather information to build a network of data to
perform a computational bioinformatics analysis. Our results showed strong interaction of the above
players and its downstream effectors in POAG pathogenesis. In conclusion, specific risk factors
were identified, and molecules involved in multiple pathways were found in relation to anterior and
posterior eye segment glaucoma changes, pointing to new theranostic challenges for better managing
POAG progression
Computational analysis of clinical and molecular markers and new theranostic possibilities in primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is a paramount cause of irreversible visual
disability worldwide. We focus on identifying clinical and molecular facts that may help
elucidating the pathogenic mechanisms of the disease. By using ophthalmological approaches
(biomicroscopy, ocular fundus, optical coherence tomography, and perimetry) and experimental
tests (enzyme-linked immunosorbent assay (ELISA), high performance liquid chromatography
(HPLC), and Western blot/immunoblotting) directed to evaluate the oxidative stress, inflammation,
apoptosis, and neurodegeneration processes, we gather information to build a network of data to
perform a computational bioinformatics analysis. Our results showed strong interaction of the above
players and its downstream effectors in POAG pathogenesis. In conclusion, specific risk factors
were identified, and molecules involved in multiple pathways were found in relation to anterior and
posterior eye segment glaucoma changes, pointing to new theranostic challenges for better managing
POAG progression