Autler-Townes splitting in two-color photoassociation of 6Li

We report on high-resolution two-color photoassociation spectroscopy in the triplet system of magneto-optically trapped 6Li. The absolute transition frequencies have been measured. Strong optical coupling of the bound molecular states has been observed as Autler-Townes splitting in the photoassociation signal. The spontaneous bound-bound transition rate is determined and the molecule formation rate is estimated. The observed lineshapes are in good agreement with the theoretical model.Comment: 5 pages, 4 figures, accepted for publication in Phys. Rev. A (Rapid Communication

Long range scattering resonances in strong-field seeking states of polar molecules

We present first steps toward understanding the ultracold scattering properties of polar molecules in strong electric field-seeking states. We have found that the elastic cross section displays a quasi-regular set of potential resonances as a function of the electric field, which potentially offers intimate details about the inter-molecular interaction. We illustrate these resonances in a ``toy'' model composed of pure dipoles, and in more physically realistic systems. To analyze these resonances, we use a simple WKB approximation to the eigenphase, which proves both reasonably accurate and meaningful. A general treatment of the Stark effect and dipolar interactions is also presented

A New Version of Reimers' law of Mass Loss Based on a Physical Approach

We present a new semi-empirical relation for the mass loss of cool stellar winds, which so far has frequently been described by "Reimers' law". Originally, this relation was based solely on dimensional scaling arguments without any physical interpretation. In our approach, the wind is assumed to result from the spill-over of the extended chromosphere, possibly associated with the action of waves, especially Alfven waves, which are used as guidance in the derivation of the new formula. We obtain a relation akin to the original Reimers law, but which includes two new factors. They reflect how the chromospheric height depends on gravity and how the mechanical energy flux depends, mainly, on effective temperature. The new relation is tested and sensitively calibrated by modelling the blue end of the Horizontal Branch of globular clusters. The most significant difference from mass loss rates predicted by the Reimers relation is an increase by up to a factor of 3 for luminous late-type (super-)giants, in good agreement with observations.Comment: 12 pages, 4 figures, accepted by ApJ Letter

Flaring Up All Over -- Radio Activity in Rapidly-Rotating Late-Type M and L Dwarfs

We present Very Large Array observations of twelve late M and L dwarfs in the Solar neighborhood. The observed sources were chosen to cover a wide range of physical characteristics - spectral type, rotation, age, binarity, and X-ray and H\alpha activity - to determine the role of these properties in the production of radio emission, and hence magnetic fields. Three of the twelve sources, TVLM513-46546, 2MASS J0036159+182110, and BRI0021-0214, were observed to flare and also exhibit persistent emission, indicating that magnetic activity is not quenched at the bottom of the main sequence. The radio emission extends to spectral type L3.5, and there is no apparent decrease in the ratio of flaring luminosities to bolometric luminosities between M8-L3.5. Moreover, contrary to the significant drop in persistent H\alpha activity beyond spectral type M7, the persistent radio activity appears to steadily increase between M3-L3.5. Similarly, the radio emission from BRI0021-0214 violates the phenomenological relations between the radio and X-ray luminosities of coronally active stars, hinting that radio and X-ray activity are also uncorrelated at the bottom of the main sequence. The radio active sources that have measured rotational velocities are rapid rotators, Vsin(i)>30 km/sec, while the upper limits on radio activity in slowly-rotating late M dwarfs (Vsin(i)<10 km/sec) are lower than these detections. These observations provide tantalizing evidence that rapidly-rotating late M and L dwarfs are more likely to be radio active. This possible correlation is puzzling given that the observed radio emission requires sustained magnetic fields of 10-1000 G and densities of 10^12 cm^-3, indicating that the active sources should have slowed down considerably due to magnetic braking.Comment: Accepted to ApJ; Two new figures; Minor text revision

Young Suns Exoplanet Survey: Detection of a wide-orbit planetary-mass companion to a solar-type Sco-Cen member

The Young Suns Exoplanet Survey consists of a homogeneous sample of 70 young, solar-mass stars located in the Lower Centaurus-Crux subgroup of the Scorpius-Centaurus association with an average age of 15 ± 3 Myr. We report the detection of a co-moving companion around the K3IV star TYC 8998-760-1 (2MASSJ13251211–6456207) that is located at a distance of 94.6 ± 0.3 pc using SPHERE/IRDIS on the VLT. Spectroscopic observations with VLT/X-SHOOTER constrain the mass of the star to 1.00±0.02M⊙ and an age of 16.7±1.4 Myr. The companion TYC 8998-760-1 b is detected at a projected separation of 1.71″, which implies a projected physical separation of 162 au. Photometric measurements ranging from Y to M band provide a mass estimate of 14±3 M_(jup) by comparison to BT-Settl and AMES-dusty isochrones, corresponding to a mass ratio of q = 0.013 ± 0.003 with respect to the primary. We rule out additional companions to TYC 8998-760-1 that are more massive than 12 M_(jup) and farther than 12 au away from the host. Future polarimetric and spectroscopic observations of this system with ground and space based observatories will facilitate testing of formation and evolution scenarios shaping the architecture of the circumstellar environment around this ‘young Sun’

Saturation in heteronuclear photoassociation of 6Li7Li

We report heteronuclear photoassociation spectroscopy in a mixture of magneto-optically trapped 6Li and 7Li. Hyperfine resolved spectra of the vibrational level v=83 of the singlet state have been taken up to intensities of 1000 W/cm^2. Saturation of the photoassociation rate has been observed for two hyperfine transitions, which can be shown to be due to saturation of the rate coefficient near the unitarity limit. Saturation intensities on the order of 40 W/cm^2 can be determined.Comment: 5 pages, 3 figures, to appear in Phys. Rev. A (Rapid Communication

Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels

The cytokine TGFβ provides important information during embryonic development, adult tissue homeostasis, and regeneration. Alterations in the cellular response to TGFβ are involved in severe human diseases. To understand how cells encode the extracellular input and transmit its information to elicit appropriate responses, we acquired quantitative time-resolved measurements of pathway activation at the single-cell level. We established dynamic time warping to quantitatively compare signaling dynamics of thousands of individual cells and described heterogeneous single-cell responses by mathematical modeling. Our combined experimental and theoretical study revealed that the response to a given dose of TGFβ is determined cell specifically by the levels of defined signaling proteins. This heterogeneity in signaling protein expression leads to decomposition of cells into classes with qualitatively distinct signaling dynamics and phenotypic outcome. Negative feedback regulators promote heterogeneous signaling, as a SMAD7 knock-out specifically affected the signal duration in a subpopulation of cells. Taken together, we propose a quantitative framework that allows predicting and testing sources of cellular signaling heterogeneity

A Comparison of Outflow Properties in AGN Dwarfs vs. Star Forming Dwarfs

Feedback likely plays a crucial role in resolving discrepancies between observed and theoretical predictions of dwarf galaxy properties. Stellar feedback was once believed to be sufficient to explain these discrepancies, but it has thus far failed to fully reconcile theory and observations. The recent discovery of energetic galaxy-wide outflows in dwarf galaxies hosting Active Galactic Nuclei (AGN) suggests that AGN feedback may have a larger role in the evolution of dwarf galaxies than previously suspected. In order to assess the relative importance of stellar versus AGN feedback in these galaxies, we perform a detailed Keck/KCWI optical integral field spectroscopic study of a sample of low-redshift star-forming (SF) dwarf galaxies that show outflows in ionized gas in their SDSS spectra. We characterize the outflows and compare them to observations of AGN-driven outflows in dwarfs. We find that SF dwarfs have outflow components that have comparable widths (W$_{80}$) to those of outflows in AGN dwarfs, but are much less blue-shifted, indicating that SF dwarfs have significantly slower outflows than their AGN counterparts. The outflows in SF dwarfs are spatially resolved and significantly more extended than those in AGN dwarfs. The mass loss rates, momentum and energy rates of SF-driven outflows are much lower than those of AGN-driven outflows. Our results indicate that AGN feedback in the form of gas outflows may play an important role in dwarf galaxies and should be considered along with SF feedback in models of dwarf galaxy evolution.Comment: 27 pages, 25 figures, Accepted for publication in Ap

Olaparib in combination with pegylated liposomal doxorubicin for platinum-resistant ovarian cancer regardless of BRCA status: a GEICO phase II trial (ROLANDO study)

Inhibidor de PARP; Olaparib; Càncer d'ovari recurrent resistent al platíInhibidor de PARP; Olaparib; Cáncer de ovario recurrente resistente al platinoPARP inhibitor; Olaparib; Platinum-resistant recurrent ovarian cancerBackground There is limited evidence for the benefit of olaparib in platinum-resistant ovarian cancer (PROC) patients with BRCA wild-type tumors. This study investigated whether this combination of a DNA-damaging chemotherapy plus olaparib is effective in PROC regardless BRCA status. Patients and methods Patients with high-grade serous or endometrioid ovarian carcinoma and one previous PROC recurrence were enrolled regardless of BRCA status. Patients with ≤4 previous lines (up to 5 in BRCA-mut) with at least one previous platinum-sensitive relapse were included; primary PROC was allowed only in case of BRCA-mut. Patients initially received six cycles of olaparib 300 mg b.i.d. (biduum) + intravenous pegylated liposomal doxorubicin (PLD) 40 mg/m2 (PLD40) every 28 days, followed by maintenance with olaparib 300 mg b.i.d. until progression or toxicity. The PLD dose was reduced to 30 mg/m2 (PLD30) due to toxicity. The primary endpoint was progression-free survival (PFS) at 6 months (6m-PFS) by RECIST version 1.1. A proportion of 40% 6m-PFS or more was considered of clinical interest. Results From 2017 to 2020, 31 PROC patients were included. BRCA mutations were present in 16%. The median of previous lines was 2 (range 1-5). The overall disease control rate was 77% (partial response rate of 29% and stable disease rate of 48%). After a median follow-up of 10 months, the 6m-PFS and median PFS were 47% and 5.8 months, respectively. Grade ≥3 treatment-related adverse events occurred in 74% of patients, with neutropenia/anemia being the most frequent. With PLD30 serious AEs were less frequent than with PLD40 (21% versus 47%, respectively); moreover, PLD30 was associated with less PLD delays (32% versus 38%) and reductions (16% versus 22%). Conclusions The PLD–olaparib combination has shown significant activity in PROC regardless of BRCA status. PLD at 30 mg/m2 is better tolerated in the combination.This work was supported by Grupo Español de Investigación en Cáncer de Ovario (GEICO) (no grant number). AstraZeneca provided olaparib and awarded a grant to GEICO (no grant number) to pay the costs of the study but did not take part in the conduct of the current clinical trial or in the analysis and interpretation of the results. Pegylated ribosomal doxorubicin was provided by the sites according to local standard procedures