Gender-specific differences of bronchial asthma phenotypes in children depending on puberty status

Further investigations are needed to examine the effect of gender-specific differences in changes of asthma prevalence and phenotypes in pre- and post puberty. Objective of the study was to evaluate if sex-based differences exist in clinical and epidemiologic characteristics of asthma in children before and after puberty

Indicators of the bronchial lability and hyperreactivity in children with bronchial asthma and exercise induced bronchoconstriction

The results of the analysis of the bronchial hyperreactivity indicators in 60 children suffering from asthma with exercise induced bronchoconstriction and without exercise induced bronchospasm are presented in the article. It has been established that higher bronchial lability was typical for children with asthma and exercise induced bronchoconstriction. The bronchial hypersensitivity to inhaled histamine in a concentration less than 0,4 mg/ml with 77 % specificity, 71 % post-test probability and significant odds ratio indicate a phenotype of childhood asthma with exercise induced bronchoconstriction

Diagnostic significance of markers of severe course of neonatal sepsis according to different clinical scales

Neonatal sepsis is a common disease with a prognostic high mortality rate, even in highly developed countries. The severity of the disease during hospitalization is a recognized factor in predicting morbidity and mortality, therefore, in order to standardize the severity of the condition of newborns in neonatal departments special clinical scales are used that take into account different degrees of dysfunction of organs and systems. A comparative analysis of eight different clinical scales for assessing the severity of the neonatal sepsis and hypothetical laboratory markers of its severity is relevant