Collective Correlations of Brodmann Areas fMRI Study with RMT-Denoising

We study collective behavior of Brodmann regions of human cerebral cortex using functional Magnetic Resonance Imaging (fMRI) and Random Matrix Theory (RMT). The raw fMRI data is mapped onto the cortex regions corresponding to the Brodmann areas with the aid of the Talairach coordinates. Principal Component Analysis (PCA) of the Pearson correlation matrix for 41 different Brodmann regions is carried out to determine their collective activity in the idle state and in the active state stimulated by tapping. The collective brain activity is identified through the statistical analysis of the eigenvectors to the largest eigenvalues of the Pearson correlation matrix. The leading eigenvectors have a large participation ratio. This indicates that several Broadmann regions collectively give rise to the brain activity associated with these eigenvectors. We apply random matrix theory to interpret the underlying multivariate data

Antioxidant Networks In vivo

Oxygen interacts with cells and can form highly reactive compounds in vivo known as reactive oxygen species (ROS). High levels of ROS can lead to cellular damage, oxidative stress, heart diseases and cancer. Known substances that are capable of halting the physiological process of oxidation in tissue are called antioxidants.This review covers developments in the field of antioxidant chemistry including interactions between antioxidants and ROS, topics about sources and natural occurrences, classification of antioxidants and a discussion of possible mechanisms. We also summarize examples of oxidative stress biomarkers.

Detection of fluorine labeled Herceptin using cellular 19F MRI ex vivo

The aim of this study was to assess the Herceptin efficacy in ex vivo cultures of MCF-7 breast carcinoma cells. Herceptin was used with perfluorooctyl bromide (PFOB) and conjugated with Lipoplex, containing plasmid DNA and Lipofectamine (LipA), to allow fluorine-19 magnetic resonance imaging (19F MRI) study. Treatments such as Herceptin, Herceptin/PFOB and Herceptin/PFOB/Lipoplex were used for ex vivo targeting of MCF-7 cells cultured in three-dimensional (3D) geometry using hollow fiber bioreactor (HFB) device. The viability of MCF-7 cells after 72 h treatments decreased to 54 \ub1 2%, 50 \ub1 3% and 45 \ub1 1% for Herceptin, Herceptin/PFOB and Herceptin/PFOB/Lipoplex, respectively. The EC50 values were 1000 \u3bcg/ml, 930 \u3bcg/ml and 730 \u3bcg/ml, respectively. The significant correlation between the treatment concentration and efficacy was observed in MCF-7 cell cultures.Peer reviewed: YesNRC publication: Ye

Technical report 009-VB-001 On 9.15 MHz dual breast coil

Peer reviewed: NoNRC publication: Ye

Technical report 300-QV-12 On 300 MHz quadrature volume coil for ferret imaging in vivo

Peer reviewed: NoNRC publication: Ye

Technical report 75/300 /V/S-001 On set up for rat head proton decoupled \ub9\ub3C spectroscopy in vivo

Peer reviewed: NoNRC publication: Ye

Technical report 008-VB-002 On 8.22 MHz dual breast coil

Peer reviewed: NoNRC publication: Ye

Technical report 015-RXQ-001 On 15.09 MHz four channel phased array coil for spine imaging

Peer reviewed: NoNRC publication: Ye

Technical report 500-LV-01 On 500 MHz volume saddle coil

Peer reviewed: NoNRC publication: Ye