Dealing with Global Problems in an Interdependent World Economy

Many problems confronting the world today pose the threat of disasters over time that could endanger the very existence of mankind. They exert enormous influence on every society and national economy. These problems cannot be overcome on the basis of actions taken by an individual nation alone. They are global problems requiring comprehensive international cooperation and coordination. Research is necessary on the causes and consequences, and possible solutions, to these global problems. Suitable institutions and mechanisms have to be developed to deal with problems from a global viewpoint, giving voice to the now-mute global economy and all of mankind

X-Irradiation-Induced Disorganization of Cytoskeletal Filaments and Cell Contacts in HT29 Cells

Organization of cytoskeleton and cell contacts were studied by immunochemistry and electron microscopy in confluent HT29 cultured cells following exposure to 0.5 and 1.0 Gy doses of X-ray. Microtubules were resistant to irradiation, whereas, the actin and intermediate filaments disrupted rapidly following the treatment and their components appeared as clumps of actin and cytokeratin aggregates in the cytoplasm as demonstrated by immunochemistry. Loss of cell contacts and decrease in the number of desmosomes was also characteristic of irradiated cells. Electron microscopy revealed intact desmosomes in control cells and abnormal desmosomes in the irradiated samples characterized by the absence of tonofilaments. The perinuclear filament network and cortical filaments were well detectable by electron microscopy. Under the effect of irradiation, the perinuclear filaments almost disappeared and, at the same time, small bundles of filaments were formed irregularly in the cytoplasm associated with amorphous material

On Gauge Invariance and Spontaneous Symmetry Breaking

We show how the widely used concept of spontaneous symmetry breaking can be explained in causal perturbation theory by introducing a perturbative version of quantum gauge invariance. Perturbative gauge invariance, formulated exclusively by means of asymptotic fields, is discussed for the simple example of Abelian U(1) gauge theory (Abelian Higgs model). Our findings are relevant for the electroweak theory, as pointed out elsewhere.Comment: 13 pages, latex, no figure

Space of State Vectors in PT Symmetrical Quantum Mechanics

Space of states of PT symmetrical quantum mechanics is examined. Requirement that eigenstates with different eigenvalues must be orthogonal leads to the conclusion that eigenfunctions belong to the space with an indefinite metric. The self consistent expressions for the probability amplitude and average value of operator are suggested. Further specification of space of state vectors yield the superselection rule, redefining notion of the superposition principle. The expression for the probability current density, satisfying equation of continuity and vanishing for the bound state, is proposed.Comment: Revised version, explicit expressions for average values and probability amplitude adde

Quantitative analysis of regulatory flexibility under changing environmental conditions

The circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops. Theory suggested that multiple loops contribute the flexibility for molecular rhythms to track multiple phases of the external cycle. Clear dawn- and dusk-tracking rhythms illustrate the flexibility of timing in Ipomoea nil. Molecular clock components in Arabidopsis thaliana showed complex, photoperiod-dependent regulation, which was analysed by comparison with three contrasting models. A simple, quantitative measure, Dusk Sensitivity, was introduced to compare the behaviour of clock models with varying loop complexity. Evening-expressed clock genes showed photoperiod-dependent dusk sensitivity, as predicted by the three-loop model, whereas the one- and two-loop models tracked dawn and dusk, respectively. Output genes for starch degradation achieved dusk-tracking expression through light regulation, rather than a dusk-tracking rhythm. Model analysis predicted which biochemical processes could be manipulated to extend dusk tracking. Our results reveal how an operating principle of biological regulators applies specifically to the plant circadian clock

Glaciation of the Northern Velebit

Prvi put su utvrđeni tragovi pleistocenske oledbe područja Sjevernog Velebita. Oni se odnose i na egzaracijske morfološke oblike i na odgovarajuće korelativne sedimente i morenske oblike.The mapping of the North Velebit region provided for the first time the evidence of glaciation traces. Three glaciation types have been determined: cirque, valley and plateau glaciation. The glaciation affected the top part of the mountain, above 1400 meters height. Therefore, the glaciation had regional properties. The following morphological forms have been positively found out and mapped: exara-tion forms (glacier valleys, cirques, aretes, striae and polished surfaces) and accumulation glacial morphological forms. Moraine forms (frontal, terminal, slope and end moraines) undoubtedly point out that the North Velebit glaciation occured two stages. There were three glaciation centres: in the Zavižan basin, Lubeno-vačko polje and on the Jezero plateau. From the basin »Lubenovačko polje« ice was flowing versus the Alan pass and in three parts versus the Bakovac valley and the »Veliki kotao« basin. A whole range of stadial, frontal and terminal moraines has been discovered. The longest one was the so called glacier of »Lomska duliba« over 10 km) which originated in the Zavižan basin. The terminal moraine was formed in Studena draga. A plateau-like glacier glided with one arm towards the Krasno polje basin and with another one through the Apatišanska duliba. For both arms, the corresponding frontal and terminal moraines have been discovered

Common Space of Spin and Spacetime

Given Lorentz invariance in Minkowski spacetime, we investigate a common space of spin and spacetime. To obtain a finite spinor representation of the non-compact homogeneous Lorentz group including Lorentz boosts, we introduce an indefinite inner product space (IIPS) with a normalized positive probability. In this IIPS, the common momentum and common variable of a massive fermion turn out to be ``doubly strict plus-operators''. Due to this nice property, it is straightforward to show an uncertainty relation between fermion mass and proper time. Also in IIPS, the newly-defined Lagrangian operators are self-adjoint, and the fermion field equations are derivable from the Lagrangians. Finally, the nonlinear QED equations and Lagrangians are presented as an example.Comment: 17 pages, a reference corrected, final version published on Foundations of Physics Letters in June of 2005, as a personal tribute to Einstein and Dira

High-Resolution Image Reconstruction from a Sequence of Rotated and Translated Frames and its Application to an Infrared Imaging System

Some imaging systems employ detector arrays that are not sufficiently dense to meet the Nyquist criterion during image acquisition. This is particularly true for many staring infrared imagers. Thus, the full resolution afforded by the optics is not being realized in such a system. This paper presents a technique for estimating a high-resolution image, with reduced aliasing, from a sequence of undersampled rotated and translationally shifted frames. Such an image sequence can be obtained if an imager is mounted on a moving platform, such as an aircraft. Several approaches to this type of problem have been proposed in the literature. Here we extend some of this previous work. In particular, we define an observation model that incorporates knowledge of the optical system and detector array. The high-resolution image estimate is formed by minimizing a regularized cost function based on the observation model. We show that with the proper choice of a tuning parameter, our algorithm exhibits robustness in the presence of noise. We consider both gradient descent and conjugate-gradient optimization procedures to minimize the cost function. Detailed experimental results are provided to illustrate the performance of the proposed algorithm using digital video from an infrared imager

A switchable light-input, light-output system modelled and constructed in yeast

<p>Abstract</p> <p>Background</p> <p>Advances in synthetic biology will require spatio-temporal regulation of biological processes in heterologous host cells. We develop a light-switchable, two-hybrid interaction in yeast, based upon the Arabidopsis proteins PHYTOCHROME A and FAR-RED ELONGATED HYPOCOTYL 1-LIKE. Light input to this regulatory module allows dynamic control of a light-emitting LUCIFERASE reporter gene, which we detect by real-time imaging of yeast colonies on solid media.</p> <p>Results</p> <p>The reversible activation of the phytochrome by red light, and its inactivation by far-red light, is retained. We use this quantitative readout to construct a mathematical model that matches the system's behaviour and predicts the molecular targets for future manipulation.</p> <p>Conclusion</p> <p>Our model, methods and materials together constitute a novel system for a eukaryotic host with the potential to convert a dynamic pattern of light input into a predictable gene expression response. This system could be applied for the regulation of genetic networks - both known and synthetic.</p

Pseudo-Hermitian Hamiltonians, indefinite inner product spaces and their symmetries

We extend the definition of generalized parity $P$, charge-conjugation $C$ and time-reversal $T$ operators to nondiagonalizable pseudo-Hermitian Hamiltonians, and we use these generalized operators to describe the full set of symmetries of a pseudo-Hermitian Hamiltonian according to a fourfold classification. In particular we show that $TP$ and $CTP$ are the generators of the antiunitary symmetries; moreover, a necessary and sufficient condition is provided for a pseudo-Hermitian Hamiltonian $H$ to admit a $P$-reflecting symmetry which generates the $P$-pseudounitary and the $P$-pseudoantiunitary symmetries. Finally, a physical example is considered and some hints on the $P$-unitary evolution of a physical system are also given.Comment: 20 page