Features of the mechanism of unlawful appropriation of vehicles during martial law

Today, the unlawful appropriation of vehicles in wartime is relevant because Ukrainians are faced with the problem of preserving their property during the war. The purpose of the paper is to consider the features of the mechanism of unlawful appropriation of vehicles in wartime, to identify and classify the subjects of their commission, to disclose and systematise the methods, means, and place of committing such crimes in accordance with the type of subject of their commission. To solve these issues, the study used a complex of both general scientific and special methods of scientific knowledge – system-structural, formal-logical, method of scientific knowledge, induction, deduction, analysis, synthesis, generalisation. Based on the results of the study, the features of the mechanism of unlawful appropriation of vehicles in wartime were established and disclosed. The subject of unlawful appropriation of vehicles during martial law was described and its classification was presented. The features of the method of committing unlawful appropriation of vehicles, depending on the subject of commission, were identified. A proportional dependence on the type of subject of committing a crime to the conditions, goals, means, and place of unlawful appropriation of vehicles in wartime was established. The methods of committing such crimes were systematised. Wartime conditions that promote unhindered unlawful appropriation of vehicles were established. Places of unlawful appropriation of vehicles during martial law were identified and classified. Purposes of committing unlawful appropriation of vehicles during martial law were investigated. The practical value of this study lies in the fact that the results obtained can serve as a basis for further scientific activities to investigate the features of the mechanism for unlawful appropriation of vehicles in wartime and used to more effectively counteract unlawful appropriation of vehicles, especially during martial la

Integration of OpenCV in an Android app to measure antero-posterior knee translation

Postprint (published version

Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve

Background: The amino acid transporter B0AT1 (SLC6A19) accomplishes concentrative cellular uptake of neutral amino acids. SLC6A19 is stimulated by serum- & glucocorticoid-inducible kinase (SGK) isoforms. SGKs are related to PKB/Akt isoforms, which also stimulate several amino acid transporters. PKB/Akt modulates glucose transport in part by phosphorylating and thus activating phosphatidylinositol-3-phosphate-5-kinase (PIKfyve), which fosters carrier protein insertion into the cell membrane. The present study explored whether PKB/Akt and/or PIKfyve stimulate SLC6A19. Methods: SLC6A19 was expressed in Xenopus oocytes with or without wild-type PKB/Akt or inactive T308A/S473APKB/Akt without or with additional expression of wild-type PIKfyve or PKB/Akt-resistant S318APIKfyve. Electrogenic amino acid transport was determined by dual electrode voltage clamping. Results: In SLC6A19-expressing oocytes but not in water-injected oocytes, the addition of the neutral amino acid L-leucine (2 mM) to the bath generated a current (Ile), which was significantly increased following coexpression of PKB/Akt, but not by coexpression of T308A/S473APKB/Akt. The effect of PKB/Akt was augmented by additional coexpression of PIKfyve but not of S318APIKfyve. Coexpression of PKB/Akt enhanced the maximal transport rate without significantly modifying the affinity of the carrier. The decline of Ile following inhibition of carrier insertion by brefeldin A (5 µM) was similar in the absence and presence of PKB/Akt indicating that PKB/Akt stimulated carrier insertion into rather than inhibiting carrier retrieval from the cell membrane. Conclusion: PKB/Akt up-regulates SLC6A19 activity, which may foster amino acid uptake into PKB/Akt-expressing epithelial and tumor cells

В ЛУЧШИХ ТРАДИЦИЯХ УНИВЕРСИТЕТСКОГО ОБРАЗОВАНИЯ. К 115-ЛЕТИЮ БИБЛИОТЕКИ МИТХТ

The article is devoted to some pages in the history of the library of one of Russia’s oldest higher education institutions, M.V. Lomonosov Moscow Institute of Fine Chemical Technology (MITHT): the organization of the library at the Moscow High Women Courses (1901-1918), the main library of the 2nd MSU (1918-1930), the MITHT scientific and technical library (1930-2015). The today’s library of the MITHT campus of the Moscow Technological University is described. The contribution of outstanding scientists that taught at different times in MITHT to the creation of the specialized university type library is noted. The surnames of the MITHT library managers starting with the Soviet period are given. Some information is published for the first time.Статья посвящена некоторым страницам истории библиотеки одного из старейших вузов России -Московского института тонкой химической технологии им. М.В. Ломоносова (МИТХТ): организация библиотеки на Московских высших женских курсах (1901-1918 гг.), фундаментальная библиотека 2-го МГУ (1918-1930 гг.), научно-техническая библиотека МИТХТ (1930-2015 гг.). Рассказывается о сегодняшнем дне библиотеки кампуса МИТХТ Московского технологического университета. Отмечается вклад выдающихся ученых, преподававших в разное время в МИТХТ, в дело создания специализированной вузовской библиотеки университетского типа. Приводятся фамилии заведующих библиотекой МИТХТ, начиная с советского периода. Ряд материалов публикуется впервые

МИТХТ В ГОДЫ ВЕЛИКОЙ ОТЕЧЕСТВЕННОЙ ВОЙНЫ (1941-1945 гг.). НАЧАЛО ВОЙНЫ

The article is dedicated to the memorable tragic date - to the 75th anniversary of the beginning of the Great Patriotic War of 1941-1945 and to the activity of the Lomonosov Moscow Institute of Fine Chemical Technology in 1941-1942: mobilization, evacuation, renewal of the educational and scientific activity in the conditions of the martial law.Статья посвящена памятной трагической дате - 75-летию начала Великой Отечественной войны 1941-1945 гг. и деятельности Московского института тонкой химической технологии имени М.В. Ломоносова (МИТХТ) в 1941-1942 гг.: мобилизация, эвакуация, возобновление образовательной и научной деятельности в условиях военного положения

Малая Пироговская, дом 1: история здания МВЖК - 2-го МГУ - МИТХТ

The article is devoted to the history of the construction of the physicochemical building of the Moscow Higher Women's Courses (1907-1908) on Malaya Tsaritsinskaya street, now the MITHT named after M. V. Lomonosov building on Malaya Pirogovskaya street.Статья посвящена истории строительства Физико-химического корпуса Московских высших женских курсов (1907-1908 гг.) на Малой Царицынской улице, ныне здания МИТХТ им. М.В. Ломоносова на Малой Пироговской улице. Большую роль тогда сыграли выдающиеся организационные способности первого избранного директора МВЖК С.А. Чаплыгина и блестящие инженерные расчеты и решения профессора А.А. Эйхенвальда. В статье использованы уникальные архивные документы, непосредственно относящиеся ко времени постройки корпусов Московских высших женских курсов

НИКОЛАЙ ПРОКОФЬЕВИЧ ФЕДОРЕНКО: ТОЧНЫЙ РАСЧЕТ И ПРЕДВИДЕНИЕ

The article is devoted to the 100th anniversary of the birth of Nikolay Prokofyevich Fedorenko, a graduate of M.V. Lomonosov MITHT, a participant of the Great Patriotic War, the head of MITHT department for chemical industry economy (1951-1962), since 1953 to 1958 - the deputy director of MITHT for studies. N.P. Fedorenko is Doctor of Economics, professor, academician of the Academy of Sciences of the USSR, member of the presidium of the Academy of Sciences of the USSR, academician-secretary of the Economy department of the Academy of Sciences of the USSR, one of the main founders and the first director of the Central Economics and Mathematics Institute of the Academy of Sciences of the USSR (1963-1985). N.P. Fedorenko was the most talented organizer of the economic science. He made a large contribution to the chemicalization of the national economy, to the application of modern mathematical methods and computing hardware for economic research, to the planning, management and studying of the theoretical and methodological bases of optimum performance of economy.Статья посвящена 100-летию со дня рождения Николая Прокофьевича Федоренко, выпускника МИТХТ им. М.В. Ломоносова, участника Великой Отечественной войны, заведующего кафедрой экономики химической промышленности МИТХТ (1951-1962 гг.), с 1953 г. по 1958 г. - заместителя директора МИТХТ по учебной работе. Н.П. Федоренко - доктор экономических наук, профессор, академик АН СССР, член президиума АН СССР, академик-секретарь Отделения экономики АН СССР, один из главных основателей и первый директор ЦЭМИ АН СССР (1963-1985), талантливейший организатор экономической науки, внесший крупный вклад в разработку проблем химизации народного хозяйства, в применение современных математических методов и вычислительной техники для экономических исследований, в планирование, управление, изучение теоретических и методологических основ оптимального функционирования экономики

Академик Вернадский у истоков преподавания на московских высших женских курсах

Article is devoted to the great Russian scientist and philosopher, academician Vladimir Ivanovich Vernadsky (1863−1945). Bases of the mineralogical school established by V.I. Vernadsky and course of mineralogy are still relevant todayСтатья посвящена великому русскому ученому и мыслителю, академику Владимиру Ивановичу Вернадскому (1863−1945), стоявшему у истоков преподавания на Московских высших женских курсах, впоследствии МИТХТ им. М.В. Ломоносова. Заложенные В.И. Вернадским основы минералогической школы, поставленный курс минералогии сохраняют свою актуальность и сегодня. Приводятся интересные факты о демарше профессоров (в том числе В.И. Вернадского) из Московского университета в 1911 году вследствие неправомерной политики министра народного просвещения Л.А. Кассо

A New Method for Treating Burn Wounds Using Targeted Delivery of Medicinal Substances by Magnetic Nanocarrier (Experimental Part)

Проведено экспериментальное исследование на лабораторных животных по изучению эффективности адресной доставки мази левомеколь с помощью магнитных наночастиц и внешнего магнитного поля при термических ожогах. В исследовании принимало участие 20 крыс с двумя очагами ожога. Крысы были разделены на 4 группы: без лечения, терапия с использованием мази левомеколь, лечение с использованием наночастиц, мази левомеколь и внешнего магнитного поля и только магнитотерапии. При гистологическом исследовании на 14-е сутки во всех группах в зоне термического повреждения кожи были отмечены признаки глубокого ожога III и IV степени с распространением некроза на всю глубину дермы и на мышцы. В группе с наночастицами, мазью левомеколь и магнитным полем на фоне уменьшения воспаления отмечалось очаговое появление грануляционной ткани. Таким образом, гистологические исследования ожогового раневого процесса лабораторных животных показали, что использование инновационного биологически активного ранозаживляющего средства на основе наночастиц в сочетании с мазью левомеколь улучшает регенерацию тканей и приводит к ускорению эпителизации, что в целом повышает результаты лечения ожоговой раны. Использование внешнего магнитного поля способствует адресной доставке лечебного нанокомплекса и поддержанию оптимальной концентрации препарата в ранеExperimental studies have been carried out on laboratory animals to investigate the effectiveness of targeted delivery of levomekol ointment using magnetic nanoparticles and an external magnetic field for treatment of thermal burns. The study involved 20 rats, with two burns on each. The rats were divided into 4 groups: untreated; treated with levomekol ointment; treated with levomekol ointment associated with nanoparticles and an external magnetic field; and treated with magnetic field alone. Histological examination was conducted on Day 14, and in all groups, in the thermal burn zone of the skin there were signs of deep three- and four-degree burns with necrosis spread through the dermis, reaching the muscle. In the group with levomekol ointment associated with nanoparticles and magnetic field, inflammation was decreased, and focal granulation tissue formation was observed. Thus, histological studies of the burn wound process in laboratory animals showed that the use of an innovative biologically active wound healing agent based on nanoparticles in combination with the levomecol ointment improved tissue regeneration and accelerated epithelialization, which enhanced the effectiveness of burn wound treatment. The use of an external magnetic field facilitated targeted delivery of the therapeutic nanosystem and maintenance of the optimal concentration of the drug in the woun

Towards Better Understanding of Etiological Mechanisms at the Neuromuscular Junction

The neuromuscular junction (NMJ) serves as a model for understanding the mechanisms that determine communication between neurons and their target cells. Disorders of the NMJ can be either autoimmune or genetic (hereditary). The autoimmune disorder myasthenia gravis (MG) is caused by antibodies against the presynaptic nerve terminal or the postsynaptic muscle membrane, which make up the NMJ. The most common antibodies are directed against the acetylcholine receptor (AChR) or muscle specific tyrosine kinase (MuSK). An alternative to expand on preclinical in-vivo methods for studying mechanisms underlying diseases of neuromuscular transmission is to apply physiologic in-vitro models that would allow tissue-tissue as well as cell-cell interactions. A system that would allow cell-cell interactions in a biological fashion is the micro-electrode array (MEA) chip that allows co-culturing of motor neurons and muscle cells. The primary hypothesis is that the suggested MEA can be used in creating a reliable model for healthy and diseased NMJ, allowing for manipulations and treatment assays. The secondary hypothesis is that small non-coding RNA, so called microRNAs (miRNA) have a specific role in neuromuscular transmission and in MG. Study I demonstrated a method of long-term muscle cell culture on the MEA chips, which allows us to trace the development of muscle cells through the observation of their electrical activity at subcellular resolution. The maturation of skeletal muscle tissue was accompanied by a gradual increase in the amplitude and frequency of extracellular individual electrical spikes. The mature muscle tissue demonstrated the steady electrical activity with synchronized spike propagation in different directions across the chip. Study II showed a specific upregulated profile of miRNAs in the muscles of MuSK antibody seropositive MG mice. Transfection of these miRNAs, miR-1933 and miR-1930, promoted downregulation of several proteins and further confirmation with qPCR revealed a specific blocking of IMPA1 and MRPL27, which are involved in intracellular signal transduction and mitochondrial biogenesis in skeletal muscles. Study III revealed no correlation between the morphology of skeletal muscle cells and their electrical activity at an early developmental stage. However, the application of recombinant rat agrin increased the number of AChRs clusters in the culture of skeletal muscle and promoted a higher degree of spontaneous activity