Use of Urinary Pregnanediol 3-glucuronide to Confirm Ovulation

Objective Urinary hormonal markers may assist in increasing the efficacy of Fertility Awareness Based Methods (FABM). This study uses urinary pregnanediol-3a-glucuronide (PDG) testing to more accurately identify the infertile phase of the menstrual cycle in the setting of FABM. Methods Secondary analysis of an observational and simulation study, multicentre, European study. The study includes 107 women and tracks daily first morning urine (FMU), observed the changes in cervical mucus discharge, and ultrasonography to identify the day of ovulation over 326 menstrual cycles. The following three scenarios were tested: (A) use of the daily pregnandiol-3a-glucuronide (PDG) test alone; (B) use of the PDG test after the first positive urine luteinizing hormone (LH) kit result; (C) use of the PDG test after the disappearance of fertile type mucus. Two models were used: (1) one day of PDG positivity; or (2) waiting for three days of PDG positivity before declaring infertility. Results After the first positivity of a LH test or the end of fertile mucus, three consecutive days of PDG testing over a threshold of 5 μg/mL resulted in a 100% specificity for ovulation confirmation. They were respectively associated an identification of an average of 6.1 and 7.6 recognized infertile days. Conclusions The results demonstrate a clinical scenario with 100% specificity for ovulation confirmation and provide the theoretical background for a future development of a competitive lateral flow assay for the detection of PDG in the urine

The 3D soft X-ray cluster-AGN cross-correlation function in the ROSAT NEP survey

X-ray surveys facilitate investigations of the environment of AGNs. Deep Chandra observations revealed that the AGNs source surface density rises near clusters of galaxies. The natural extension of these works is the measurement of spatial clustering of AGNs around clusters and the investigation of relative biasing between active galactic nuclei and galaxies near clusters.The major aims of this work are to obtain a measurement of the correlation length of AGNs around clusters and a measure of the averaged clustering properties of a complete sample of AGNs in dense environments. We present the first measurement of the soft X-ray cluster-AGN cross-correlation function in redshift space using the data of the ROSAT-NEP survey. The survey covers 9x9 deg^2 around the North Ecliptic Pole where 442 X-ray sources were detected and almost completely spectroscopically identified. We detected a >3sigma significant clustering signal on scales s<50 h70^-1 Mpc. We performed a classical maximum-likelihood power-law fit to the data and obtained a correlation length s_0=8.7+1.2-0.3 h_70-1 Mpc and a slope gamma=1.7$^+0.2_-0.7 (1sigma errors). This is a strong evidence that AGNs are good tracers of the large scale structure of the Universe. Our data were compared to the results obtained by cross-correlating X-ray clusters and galaxies. We observe, with a large uncertainty, that the bias factor of AGN is similar to that of galaxies.Comment: 4 pages, 2 figure, proceedings of the Conference "At the edge of the Universe", Sintra Portugal, October 2006. To be published on the Astronomical Society of the Pacific Conference Series (ASPCS

Cosmic Structure Traced by Precision Measurements of the X-Ray Brightest Galaxy Clusters in the Sky

The current status of our efforts to trace cosmic structure with 10^6 galaxies (2MASS), 10^3 galaxy clusters (NORAS II cluster survey), and precision measurements for 10^2 galaxy clusters (HIFLUGCS) is given. The latter is illustrated in more detail with results on the gas temperature and metal abundance structure for 10^0 cluster (A1644) obtained with XMM-Newton.Comment: 4 pages; to be published in the Proceedings of the Conference: The Emergence of Cosmic Structure, College Park, MD (2002), editors: S.S. Holt and C. Reynolds; also available at http://www.reiprich.ne

The Sunyaev-Zeldovich Effect at 1 and 2 mm towards ROSAT Clusters

An observing campaign was devoted to the search for the Sunyaev-Zeldovich (S-Z) effect towards X-ray ROSAT Clusters in the millimetric spectral domain. A double channel (1.2 and 2 {\it mm}) photometer was installed at the focus of the 15m Swedish ESO Submillimeter Telescope (SEST) in Chile in september 1994 and 1995 and observations of the targets S1077, A2744, S295 and RXJ0658-5557 were gathered. Detections were found for A2744 at 1 {\it mm} and in both channels (at 1.2 and 2 {\it mm}) towards RXJ0658-5557. For the first time there is evidence for the S-Z enhancement and both the latter and the decrement were detected on the same source. We discuss astrophysical and systematic effects which could give origin to these signals.Comment: 6 pg Latex file (style file included) including 1 ps figure, XVIth Moriond Astrophysics Meeting "The Anisotropies of the Cosmic Microwave Background", Les Arcs, Savoie-France, March 16-23 199

Supermassive Black Holes in Elliptical Galaxies: Switching from Very Bright to Very Dim

Relativistic outflows (mainly observed in the radio) are a characteristic feature of both Galactic stellar mass black holes and supermassive black holes (SMBHs). Simultaneous radio and X-ray observations of Galactic sources have shown that the outflow is strong at low accretion rates, but it weakens dramatically or disappears completely at high accretion rates, manifesting structural changes in the accretion flow. It is reasonable to assume that SMBHs follow the same trend. For low luminosity SMBHs in nearby elliptical galaxies and clusters, recent observations strongly suggest that the outflows play the central role in keeping the gas hot (mechanical feedback). If the outflow is quenched in SMBHs at high accretion rates similarly to the behavior of galactic sources, then the straightforward consequence is a relatively weak feedback of rapidly accreting SMBHs. We argue that elliptical galaxies and their central engines should then evolve through two stages. Early on, the central SMBH rapidly grows by accreting cooling gas at a near-Eddington rate with high radiative efficiency but with weak feedback on the infalling gas. This stage terminates when the black hole has grown to a sufficiently large mass that its feedback (radiative and/or mechanical), despite the low gas heating efficiency, is able to suppress gas cooling. After that the system switches to a stable state corresponding to passively evolving ellipticals, when the accretion rate and radiative efficiency are very low, but the gas heating efficiency is high and energy input from the relativistic outflow keeps the gas hot.Comment: MNRAS Letters, accepted, 6 pages, 2 figure

Hot Gaseous Coronae around Spiral Galaxies: Probing the Illustris Simulation

The presence of hot gaseous coronae around present-day massive spiral galaxies is a fundamental prediction of galaxy formation models. However, our observational knowledge remains scarce, since to date only four gaseous coronae were detected around spirals with massive stellar bodies ($\gtrsim2\times10^{11} \ \rm{M_{\odot}}$). To explore the hot coronae around lower mass spiral galaxies, we utilized Chandra X-ray observations of a sample of eight normal spiral galaxies with stellar masses of $(0.7-2.0)\times10^{11} \ \rm{M_{\odot}}$. Although statistically significant diffuse X-ray emission is not detected beyond the optical radii ($\sim20$ kpc) of the galaxies, we derive $3\sigma$ limits on the characteristics of the coronae. These limits, complemented with previous detections of NGC 1961 and NGC 6753, are used to probe the Illustris Simulation. The observed $3\sigma$ upper limits on the X-ray luminosities and gas masses exceed or are at the upper end of the model predictions. For NGC 1961 and NGC 6753 the observed gas temperatures, metal abundances, and electron density profiles broadly agree with those predicted by Illustris. These results hint that the physics modules of Illustris are broadly consistent with the observed properties of hot coronae around spiral galaxies. However, a shortcoming of Illustris is that massive black holes, mostly residing in giant ellipticals, give rise to powerful radio-mode AGN feedback, which results in under luminous coronae for ellipticals.Comment: 12 pages, 6 figures, accepted for publication in Ap

A Dynamical Study of Optically Selected Distant Clusters

We present a programme of spectroscopic observations of galaxies in a sample of optically-selected clusters taken from the catalogue of Couch et al (1991). Previous ROSAT observations of these clusters have shown them to have lower X-ray luminosities, given their optical richness, than might be expected on the basis of local samples. In the present paper we extend this work by determining velocity dispersions of a subsample of the clusters. We confirm the dynamical reality of all but one of the original sample, and find velocity dispersions comparable with present-day clusters of equivalent comoving space density. Thus, in the context of the $L_X-\sigma$ relation for present-day clusters, there is evidence for a higher velocity dispersion at fixed X-ray luminosity. A key question is whether the high velocity dispersions are indicative of the gravitational potential. If they are, the X-ray luminosities measured in Bower et al., 1994 (Paper I), would then imply an implausibly low efficiency of X-ray generation. Alternatively, the discrepancy could be explained if the clusters were systems of lower virial temperature, in which the apparent velocity dispersion is inflated by an infalling, unrelaxed halo. This might result either from an increase with redshift in the infall rate for clusters, or from the preferential selection of clusters embedded in filaments oriented along the line of sight. Since clusters with similar properties can be found in local optically selected catalogues, we suggest that the latter explanation is more likely.Comment: Accepted for publication in MNRAS. 13 pages plain TeX (not Latex). Uses macro files psfig.tex and mn.tex. Figures and tables included; finding charts available from http://star-www.dur.ac.uk/~rgb