Разработка системы пожаровзрывозащиты в рабочей зоне цеха производства стали ККЦ-1 АО ЗСМК г. Новокузнецк

В процессе работы был изучены способы и технологии защиты промышленных зданий от взрывов и пожаров. Проанализировано здание цеха ККЦ-1 на возможность возникновения внештатной ситуации. В результате работы была спроектирована автоматическая система водяного пожаротушения для гаража погрузчиков. Даны рекомендации по взрывозащите цеха. Основные конструктивные характеристики: Спринклерные оросители СВВ-12, насос К150-125-315а (P=30 кВт), узел управления УУ-С150/1,2Вз-ВФ.04, прибор управления "Спрут-2". Произведен полный гидравлический расчет системы с выбором необходимого оборудования.In the process, the methods and technologies of protecting industrial buildings from explosions and fires were studied. Analyzed the building of the KKTs-1 workshop for the possibility of an emergency situation. As a result of the work, an automatic fire extinguishing system was designed for the loader's garage. Recommendations for the explosion protection shop. Main design features: sprinklers СВВ-12, pump K150-125-315а (P = 30 kW), control unit УУ-С150/1,2Вз-ВФ.04, control unit "Sprut-2" A complete hydraulic calculation of the system with the selection of the necessary equipment

Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension

Dilation of resistance arteries in response to infusion of nitric oxide donors is impaired in hypertensive patients and the degree of this impairment depends critically on the severity of arterial hypertension. The reduced effectiveness of nitric oxide appears to be independent of the class of nitric oxide donor and thus of the mode of intravascular nitric oxide generation. These findings are likely to have important implications not only for our understanding of the pathophysiological mechanisms of endothelial dysfunction but also for nitric oxide donor therapy in arterial hypertension

Mechanisms of histamine-induced coronary vasodilatation: H1-receptor-mediated release of endothelium-derived nitric oxide

Although the content of histamine in myocardial tissue is high, its contribution to the regulation of coronary blood flow has not been clearly defined. The aim of the present study was to investigate whether or not nitric oxide (NO), an important modulator of coronary vascular tone, is involved in histamine-induced coronary vasomotion and to characterize which histaminergic receptor subtype mediates this process. Isolated, constant-flow-perfused guinea pig hearts were challenged with histamine, the H1-receptor agonist pyridylethylamine (PYR) and the H2-receptor agonist dimaprit (DIM). Apart from coronary perfusion pressure (CPP), left ventricular pressure (LVP) and the development of contractile force (dp/dt), the release of NO and cyclic GMP (cGMP) were continuously measured. Histamine and DIM induced concentration dependently a coronary vasodilatation with an almost 50% decrease in CPP paralleled by an enhancement of LVP and dp/dt by more than 80%. PYR selectively reduced CPP by 47% without affecting LVP and dp/dt. Histamine- and PYR-induced coronary vasodilatation were paralleled by a more-than-twofold increase in basal cGMP release from isolated hearts, whereas DIM exerted no effects on cGMP release. Oxyhemoglobin (4 µM), an effective scavenger of NO, shifted the concentration-response curve for histamine- and PYR-induced changes in CPP significantly to the right and in parallel inhibited the increase in cGMP release. Histamine and PYR rapidly (within 2 s) decreased CPP, while the onset of DIM-induced coronary vasodilatation followed changes in LVP with a lag period of 10 s. Histamine increased basal NO release concentration dependently by a maximum of 351 ± 21 pmol/min