Building Interaction with an Isolated Population through Social Media: The Deaf Community

The purpose of the study is to discover the effects of social media on the deaf community. Ten individuals, aged from 21 to 29, participated in this study. There was no control for race, ethnicity, or socioeconomic status. An Internet survey was used to gather data. Results suggest that hearing impaired individuals do use social media and that the ways in which is it used varies as a function of degree of hearing loss

Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex

The exocyst is a hetero-octameric complex that has been proposed to serve as the tethering complex for exocytosis, although it remains poorly understood at the molecular level. Here, we purified endogenous exocyst complexes from Saccharomyces cerevisiae and showed that they are stable and consist of all eight subunits with equal stoichiometry. Using a combination of biochemical and auxin induced-degradation experiments in yeast, we mapped the subunit connectivity, identified two stable four-subunit modules within the octamer and demonstrated that several known exocyst-binding partners are not necessary for exocyst assembly and stability. Furthermore, we visualized the structure of the yeast complex by using negative-stain electron microscopy; our results indicate that the exocyst exists predominantly as a stable, octameric complex with an elongated architecture that suggests that the subunits are contiguous helical bundles packed together into a bundle of long rods