155 research outputs found
Scattering and duality in the 2 dimensional OSP(2|2) Gross Neveu and sigma models
We write the thermodynamic Bethe ansatz for the massive OSp(2|2) Gross Neveu
and sigma models. We find evidence that the GN S matrix proposed by Bassi and
Leclair [12] is the correct one. We determine features of the sigma model S
matrix, which seem highly unconventional; we conjecture in particular a
relation between this sigma model and the complex sine-Gordon model at a
particular value of the coupling. We uncover an intriguing duality between the
OSp(2|2) GN (resp. sigma) model on the one hand, and the SO(4) sigma (resp. GN
model) on the other, somewhat generalizing to the massive case recent results
on OSp(4|2). Finally, we write the TBA for the (SUSY version of the) flow into
the random bond Ising model proposed by Cabra et al. [39], and conclude that
their S matrix cannot be correct.Comment: 41 pages, 27 figures. v2: minor revisio
A glimpse of a Luttinger liquid
The concept of a Luttinger liquid has recently been established as a
fundamental paradigm vital to our understanding of the properties of
one-dimensional quantum systems, leading to a number of theoretical
breakthroughs. Now theoretical predictions have been put to test by the
comprehensive experimental study.Comment: Unedited version of N&V article in Nature materials 4, 273 (2005
Molecular dynamics simulations of oscillatory Couette flows with slip boundary conditions
The effect of interfacial slip on steady-state and time-periodic flows of
monatomic liquids is investigated using non-equilibrium molecular dynamics
simulations. The fluid phase is confined between atomically smooth rigid walls,
and the fluid flows are induced by moving one of the walls. In steady shear
flows, the slip length increases almost linearly with shear rate. We found that
the velocity profiles in oscillatory flows are well described by the Stokes
flow solution with the slip length that depends on the local shear rate.
Interestingly, the rate dependence of the slip length obtained in steady shear
flows is recovered when the slip length in oscillatory flows is plotted as a
function of the local shear rate magnitude. For both types of flows, the
friction coefficient at the liquid-solid interface correlates well with the
structure of the first fluid layer near the solid wall.Comment: 31 pages, 11 figure
Lattice Boltzmann simulations in microfluidics: probing the no-slip boundary condition in hydrophobic, rough, and surface nanobubble laden microchannels
In this contribution we review recent efforts on investigations of the effect
of (apparent) boundary slip by utilizing lattice Boltzmann simulations. We
demonstrate the applicability of the method to treat fundamental questions in
microfluidics by investigating fluid flow in hydrophobic and rough
microchannels as well as over surfaces covered by nano- or microscale gas
bubbles.Comment: 11 pages, 6 figure
Domain-Based Identification and Analysis of Glutamate Receptor Ion Channels and Their Relatives in Prokaryotes
Voltage-gated and ligand-gated ion channels are used in eukaryotic organisms for the purpose of electrochemical signaling. There are prokaryotic homologues to major eukaryotic channels of these sorts, including voltage-gated sodium, potassium, and calcium channels, Ach-receptor and glutamate-receptor channels. The prokaryotic homologues have been less well characterized functionally than their eukaryotic counterparts. In this study we identify likely prokaryotic functional counterparts of eukaryotic glutamate receptor channels by comprehensive analysis of the prokaryotic sequences in the context of known functional domains present in the eukaryotic members of this family. In particular, we searched the nonredundant protein database for all proteins containing the following motif: the two sections of the extracellular glutamate binding domain flanking two transmembrane helices. We discovered 100 prokaryotic sequences containing this motif, with a wide variety of functional annotations. Two groups within this family have the same topology as eukaryotic glutamate receptor channels. Group 1 has a potassium-like selectivity filter. Group 2 is most closely related to eukaryotic glutamate receptor channels. We present analysis of the functional domain architecture for the group of 100, a putative phylogenetic tree, comparison of the protein phylogeny with the corresponding species phylogeny, consideration of the distribution of these proteins among classes of prokaryotes, and orthologous relationships between prokaryotic and human glutamate receptor channels. We introduce a construct called the Evolutionary Domain Network, which represents a putative pathway of domain rearrangements underlying the domain composition of present channels. We believe that scientists interested in ion channels in general, and ligand-gated ion channels in particular, will be interested in this work. The work should also be of interest to bioinformatics researchers who are interested in the use of functional domain-based analysis in evolutionary and functional discovery
Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine
ELIC, the pentameric ligand-gated ion channel from Erwinia chrysanthemi, is a prototype for Cys-loop receptors. Here we show that acetylcholine is a competitive antagonist for ELIC. We determine the acetylcholine–ELIC cocrystal structure to a 2.9-Å resolution and find that acetylcholine binding to an aromatic cage at the subunit interface induces a significant contraction of loop C and other structural rearrangements in the extracellular domain. The side chain of the pore-lining residue F247 reorients and the pore size consequently enlarges, but the channel remains closed. We attribute the inability of acetylcholine to activate ELIC primarily to weak cation-π and electrostatic interactions in the pocket, because an acetylcholine derivative with a simple quaternary-to-tertiary ammonium substitution activates the channel. This study presents a compelling case for understanding the structural underpinning of the functional relationship between agonism and competitive antagonism in the Cys-loop receptors, providing a new framework for developing novel therapeutic drugs
Metabolic Factors Limiting Performance in Marathon Runners
Each year in the past three decades has seen hundreds of thousands of runners register to run a major marathon. Of those who attempt to race over the marathon distance of 26 miles and 385 yards (42.195 kilometers), more than two-fifths experience severe and performance-limiting depletion of physiologic carbohydrate reserves (a phenomenon known as ‘hitting the wall’), and thousands drop out before reaching the finish lines (approximately 1–2% of those who start). Analyses of endurance physiology have often either used coarse approximations to suggest that human glycogen reserves are insufficient to fuel a marathon (making ‘hitting the wall’ seem inevitable), or implied that maximal glycogen loading is required in order to complete a marathon without ‘hitting the wall.’ The present computational study demonstrates that the energetic constraints on endurance runners are more subtle, and depend on several physiologic variables including the muscle mass distribution, liver and muscle glycogen densities, and running speed (exercise intensity as a fraction of aerobic capacity) of individual runners, in personalized but nevertheless quantifiable and predictable ways. The analytic approach presented here is used to estimate the distance at which runners will exhaust their glycogen stores as a function of running intensity. In so doing it also provides a basis for guidelines ensuring the safety and optimizing the performance of endurance runners, both by setting personally appropriate paces and by prescribing midrace fueling requirements for avoiding ‘the wall.’ The present analysis also sheds physiologically principled light on important standards in marathon running that until now have remained empirically defined: The qualifying times for the Boston Marathon
Hydrodynamic slip can align thin nanoplatelets in shear flow
The large-scale processing of nanomaterials such as graphene and MoS2 relies on understanding the flow behaviour of nanometrically-thin platelets suspended in liquids. Here we show, by combining non-equilibrium molecular dynamics and continuum simulations, that rigid nanoplatelets can attain a stable orientation for sufficiently strong flows. Such a stable orientation is in contradiction with the rotational motion predicted by classical colloidal hydrodynamics. This surprising effect is due to hydrodynamic slip at the liquid-solid interface and occurs when the slip length is larger than the platelet thickness; a slip length of a few nanometers may be sufficient to observe alignment. The predictions we developed by examining pure and surface-modified graphene is applicable to different solvent/2D material combinations. The emergence of a fixed orientation in a direction nearly parallel to the flow implies a slip-dependent change in several macroscopic transport properties, with potential impact on applications ranging from functional inks to nanocomposites.Energy Technolog
Rotating Stars in Relativity
Rotating relativistic stars have been studied extensively in recent years,
both theoretically and observationally, because of the information one could
obtain about the equation of state of matter at extremely high densities and
because they are considered to be promising sources of gravitational waves. The
latest theoretical understanding of rotating stars in relativity is reviewed in
this updated article. The sections on the equilibrium properties and on the
nonaxisymmetric instabilities in f-modes and r-modes have been updated and
several new sections have been added on analytic solutions for the exterior
spacetime, rotating stars in LMXBs, rotating strange stars, and on rotating
stars in numerical relativity.Comment: 101 pages, 18 figures. The full online-readable version of this
article, including several animations, will be published in Living Reviews in
Relativity at http://www.livingreviews.org
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