8 research outputs found
Identification of potential non-invasive biomarkers in diastrophic dysplasia.
- Author
- Publication venue
- Publication date
- 01/10/2023
- Field of study
Diastrophic dysplasia (DTD) is a recessive chondrodysplasia caused by pathogenic variants in the SLC26A2 gene encoding for a cell membrane sulfate/chloride antiporter crucial for sulfate uptake and glycosaminoglycan (GAG) sulfation. Research on a DTD animal model has suggested possible pharmacological treatment approaches. In view of future clinical trials, the identification of non-invasive biomarkers is crucial to assess the efficacy of treatments. Urinary GAG composition has been analyzed in several metabolic disorders including mucopolysaccharidoses. Moreover, the N-terminal fragment of collagen X, known as collagen X marker (CXM), is considered a real-time marker of endochondral ossification and growth velocity and was studied in individuals with achondroplasia and osteogenesis imperfecta. In this work, urinary GAG sulfation and blood CXM levels were investigated as potential biomarkers for individuals affected by DTD. Chondroitin sulfate disaccharide analysis was performed on GAGs isolated from urine by HPLC after GAG digestion with chondroitinase ABC and ACII, while CXM was assessed in dried blood spots. Results from DTD patients were compared with an age-matched control population. Undersulfation of urinary GAGs was observed in DTD patients with some relationship to the clinical severity and underlying SLC26A2 variants. Lower than normal CXM levels were observed in most patients, even if the marker did not show a clear pattern in our small patient cohort because CXM values are highly dependent on age, gender and growth velocity. In summary, both non-invasive biomarkers are promising assays targeting various aspects of the disorder including overall metabolism of sulfated GAGs and endochondral ossification
Sociocultural considerations in aging men's health: implications and recommendations for the clinician
- Author
- Anderson L.M.
- Andriole G.L.
- Anne Skamai
- Anwar S.
- Apter A.J.
- Arber S.
- Bennett I.M.
- Betancourt J.R.
- Blackhall L.J.
- Bober S.L.
- Brach C.
- Brown C.
- Brown R.L.
- Brown V.A.
- Chrisman N.
- Consedine N.S.
- Consedine N.S.
- Consedine N.S.
- Consedine N.S.
- Consedine N.S.
- Consedine N.S.
- Consedine N.S.
- Consedine N.S.
- Consedine N.S.
- Dale W.
- Davis T.C.
- de Haes H.
- DiMatteo M.R.
- Eckert J.K.
- Fillingim R.B.
- Galdas P.M.
- Gallant M.P.
- Goel M.S.
- Golin C.
- Gordon H.S.
- Hall R.H.
- Han H.
- Heisler M.
- Hyre A.D.
- Im E.
- Ironson G.
- Jackevicius C.A.
- Jackson J.S.
- Jemal A.
- Kalichman S.C.
- Kaplan R.C.
- Kirkland S.A.
- Kleinman A.
- Kreuter M.W.
- Kudadjie-Gyamfi E.K.
- Lee J.K.
- Lee M.M.
- Lerman I.
- Leventhal H.
- McCracken M.
- Moller-Leimkuhier A.M.
- Myers H.F.
- Naslindh-Yispangar A.
- Nathan S. Consedine
- Nichol M.B.
- O’Brien K.
- Peng H.
- Pereira D.B.
- Powe B.D.
- Rose L.E.
- Sadovsky R.
- Sanchez-Vaznaugh E.V.
- Shavers V.L.
- Shaw C.
- Siegel K.
- Slovic P.
- Stewart A.L.
- Teal C.R.
- Verbruge L.
- Walsh J.M.E.
- Walter F.M.
- Wens J.
- White A.
- Wilcox B.J.
- Woods V.D.
- Publication venue
- Publication date
- 01/01/2009
- Field of study
http://dx.doi.org/10.1016/j.jomh.2009.07.00
Is it insane to refuse chemotherapy?
- Author
- A. Altschuler
- A. Surbon
- A.E. Pedersen
- A.J. Mitchell
- C. Lindley
- C. Protière
- C. Protière
- C. Zimmerman
- C.G. Blanchard
- D. Razavi
- D.J. Dodwell
- D.P. Stark
- G.N. Fischer
- H.A. Llewellyn-Thomas
- J. Bonneterre
- J. Schaeffer
- J.M. Prieto
- K. Honda
- K.B. Dash
- L. Edery
- L. Edery
- L. Edery
- L.A. Bastian
- L.L. Phipps
- M. -F. Bacqué
- M. Bruchon-Schweitzer
- M. Charavel
- M. Colleoni
- M. Gattelari
- M. Harter
- M.B. Daly
- M.F. Bacqué
- M.L. Slevin
- N. Moumjid
- N.L. Keating
- P. Vennin
- P.M. Radvin
- R.J. Simes
- S. Pucheu
- S.J.T. Jansen
- S.L. Bober
- S.O. Dalton
- T. Casagrande
- T. Cotton
- V.M. Duric
- W.R. Bion
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Molecular Cloning and Sequencing of Myosin Light Chains in Human Megakaryoblastic Leukemia Cells.
- Author
- Baba M.L., Goodman, M., Berger-Coh
- Berlot C.H., Spudich, J.A., and De
- Bourguignon L.Y.W., Nagpal, M.L.,
- Fowler V.M., Davis, J.Q., and Benn
- Hartshorne D.J., and Mrwa, U.
- Henderson S.A. Xu, Y.C., and Chien
- Higashihara M., Hartshorne, D.J.,
- Higashihara M., Takahata, K., and
- Ikebe M.
- Ikebe M., Hartshorne, D.J., and El
- Ikebe M., Hartshorne, D.J., and El
- Inoue A., Yanagisawa, M., Takano-O
- Kretsinger R.H.
- Kumar C.C., Mohan, S.R., Zavodny,
- Nabeshima Y., Nabeshima, Y., Nonom
- Ogura M., Morishima, Y., Okuma, M.
- Reinach F.C., amd Fischman, D.A.
- Satterwhite L.L., Lohka, M.J., Wil
- Seidel U., Bober, E., Winter, B.,
- Siddiqui M.A.Q., and Kumar, C.C.
- Taubman M.B., Grant, J.W., and Nad
- Zavodny P.J., Petro, M.E., Kumar,
- Publication venue
- 'Japan Society of Smooth Muscle Research'
- Publication date
- 01/01/2001
- Field of study
Is chemoprevention practical?
- Author
- A. Decensi
- A.N. Freedman
- B. Fisher
- B. Fisher
- Bruce F. Kimler
- C.F. Garland
- C.J. Fabian
- C.J. Fabian
- C.J. Fabian
- C.J. Fabian
- Carol J. Fabian
- D. Grady
- D.C. Allred
- E.M. Ozanne
- E.R. Port
- E.S. Meadows
- I. Sestak
- J. Cuzick
- J. Cuzick
- J. Cuzick
- J. Cuzick
- J. Hannemann
- J. Melnikow
- J. Tchou
- K.R. Snyder
- L.C. Hartmann
- M. Allinen
- M.B. Sporn
- M.H. Gail
- M.P. Goetz
- M.R. Wrensch
- N. Hoogerbrugge
- N. Levy
- N.F. Col
- R.T. Chlebowski
- S. Martino
- S. Menon
- S.L. Bober
- S.R. Cummings
- S.R. Land
- S.S. Maruti
- T. Powles
- T.J. Powles
- U. Veronesi
- U. Veronesi
- V.C. Jordan
- V.G. Vogel
- V.G. Vogel
- V.K. Goldenberg
- W.C. Dooley
- Y. Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Strain-Annealing Based Grain Boundary Engineering to Evaluate its Sole Implication on Intergranular Corrosion in Extra-Low Carbon Type 304L Austenitic Stainless Steel
- Author
- A. Telang
- A. Telang
- A.H. King
- B. Dubuc
- B.M. Guyot
- C. Cayron
- C. Cayron
- C. Hu
- C. Kaithwas
- D. Brandon
- D.B. Bober
- E. Charkaluk
- E.A. Trillo
- E.A. Trillo
- E.M. Lehockey
- F. Shi
- G. Hou
- G. Owen
- G. Yamada
- H. Gleiter
- H. Kokawa
- H. Samet
- H.Y. Bi
- J. Qian
- K. Deepak
- K.S. Swaroop
- L.C. Lim
- M. Coleman
- M. Kumar
- M. Michiuchi
- M. Shimada
- M.B. Dillencourt
- N. Keskar
- N. Parvathavarthini
- N. Srinivasan
- P. Bhuyan
- P.M. Ahmedabadi
- P.M. Ahmedabadi
- R. Jones
- R. Singh
- R. Singh
- R.C. Newman
- R.E. Hehemann
- S. K. Pradhan
- S. Kobayashi
- S. Mandal
- S. Mandal
- S. Mandal
- S. Tsurekawa
- S. Zhang
- S.K. Pradhan
- S.X. Li
- Sumantra Mandal
- T. Watanabe
- T.H. Lee
- T.H. Lee
- T.S. Prithiv
- V. Randle
- V. Randle
- V. Randle
- V. Randle
- V. Ĉíhal
- V.Y. Gertsman
- W. Wang
- W.J. Li
- Y. Gao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Crowns, Garlands, and Ribbons for Tony Podlecki: Official and Unofficial Victory Rituals at the Athenian Dionysian Festivals
- Author
- Agelidis S.
- Amandry P.
- Bacchielli L.
- Bakola E.
- Biles Z.
- Biles Z.
- Blech M.
- Bober P.P.
- Braund D.
- Buhmann H.
- Bötticher C.
- Chronopoulos S.
- Clinton K.
- Csapo E.
- Csapo E.
- Currie B.
- de Ponte S.
- Diggle J.
- Dover K.J.
- Ganszyniec R.
- Geus K.
- Giglioli G.Q.
- Goette H.R.
- Haigh A.E.
- Hallof K
- Jüthner J.
- Kefalidou E
- Korres M.
- Kraus C.
- Kurke L.
- MacDowell D.M.
- Martzavou P.
- McCabe D.F.
- Micheli M.E.
- Miller S.G.
- Moore M.B.
- Morel J.P.
- Müller A.
- Neer R.T.
- Olson S.D.
- Parker R.
- Passow W.
- Picard C.
- Pickard-Cambridge A.
- Pochmarski E.
- Poursat J.
- Revermann M.
- Robert L.
- Schmitt-Pantel P
- Shear J. L.
- Sider D.
- Slater W.J.
- Sokolova O.Y.
- Stewart A.
- Taplin O.
- Taplin P.
- Tzachou-Alexandri O
- Valavanis P.
- van Hoorn G.
- Vanderpool E.
- Voutiras E.
- Welcker F.G.
- Wilson P.
- Wilson P.
- Wilson P.
- Zhuravlev D.V.
- ———.
- Publication venue
- 'University of Toronto Press Inc. (UTPress)'
- Publication date
- Field of study
Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis
- Author
- Aarts E.
- Abbas Z.
- Abburu S.
- Abd Ghaffar M.K.
- Abdelgalil R.
- Abdelhadi M.
- Abdikadir H.R.
- Abdulmajid A.
- Abdulrahman N.
- Abid A.
- Abid H.
- Abrisqueta Carrion J.
- Abuhussein N.
- Abul M.H.
- Acar S.
- Acherman Y.I.Z.
- Acquaah F.
- Acres M.
- Adams R.
- Adams R.D.
- Adebayo A.A.
- Adeleja I.
- Adiyaman C.
- Adjei H.
- Adlan A.
- Afzal Z.
- Agalar C.
- Agarwal V.
- Agrawal M.
- Ahern N.
- Ahmad A.
- Ahmad K.
- Ahmad S.
- Ahmed F.
- Ahmed H.
- Ahmed M.
- Ahmed N.
- Ahmed S.
- Ahn J.S.
- Aidoo-Micah G.E.
- Aildasani L.
- Aithie J.M.
- Akbulut F.
- Akcaoglu T.
- Akdogan A.
- Akhtar S.
- Akkaya E.
- Akkucuk S.
- Akpunarli B.
- Aksoy K.
- Aktas M.K.
- Aktekin H.
- Al-Mousawi A.
- Al-Nasser A.
- Al-Nasser Z.
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- Al-Robeye A.
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- Alberti Delgado P.
- Alcazar Montero J.A.
- Alcocer B.P.
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- Alim Y.E.
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- Aljbour A.
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- Publication venue
- Publication date
- 01/08/2018
- Field of study
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien–Dindo Grades III–V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49–2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46–0.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease