Connection between uterine myomas and biochemical screening results in the first and second trimester of pregnancy

Abstract Objectives: Uterine myomas may change the concentrations of the screening serum markers and therefore alter the risk calculation of the fetal chromosomal abnormalities. An increased risk leads to invasive diagnostics procedures which in these cases can often be technically difficult due to the presence of myomas. Aim: The aim of this study was to assess the influence of uterine myomas on the first and second trimester serum markers concentrations and, possibly, on the test results. Material and methods: The study group consisted of 127 women between 11 and 20 weeks of normal singleton pregnancy. In each case uterine myomas were diagnosed – over 20 mm in the diameter and located in the uterine wall. 77 patients underwent the first trimester screening (PAPP-A & free β-hCG) and 50 patients had the second trimester screening (triple test). The control group consisted of 1020 women between 11 and 20 weeks of normal singleton pregnancy without uterine myomas. Delfia Xpress analyser was used for the serum markers estimations. All pregnant women delivered normal healthy babies. Results: In the first trimester group the PAPP-A serum concentrations were not different from the controls while the mean median concentration of free β-hCG were significant higher – 1.43 MoM. In the second trimester group the following mean median values were observed: no significance for the AFP – 1.18 MoM and estriol – 1.29 MoM and significantly higher mean median value for the free β-hCG – 2.01 MoM. Conclusions: 1. The presence of the uterine myomas is connected with the increased maternal serum concentration of the β-hCG, particularly in the second trimester. 2. The uterine myomas may lead to the increased rate of the false positive results of the prenatal screening test, especially the triple test

Absolute measurement of the ^{1}S_{0} − ^{3}P_{0} clock transition in neutral ^{88}Sr over the 330 km-long stabilized fibre optic link

We report a stability below $7\times 10{}^{-17}$ of two independent optical lattice clocks operating with bosonic ${}^{88}$Sr isotope. The value (429228066418008.3(1.9)${}_{syst}$(0.9)${}_{stat}$~Hz) of the absolute frequency of the ${}^{1}S_{0}$ - ${}^{3}P_{0}$ transition was measured with an optical frequency comb referenced to the local representation of the UTC by the 330 km-long stabilized fibre optical link. The result was verified by series of measurements on two independent optical lattice clocks and agrees with recommendation of Bureau International des Poids et Mesures

Plant medicinal products and drug interactions

Introduction. Some herbal medicinal products may be beneficial in certain respects but many can be dangerous for patients taking doctor-prescribed medications. Plant medicinal products are often taken with conventional drugs by patients. Interactions are possible between herbal medicinal products and conventional medications that can lead to toxicity due to increaseddrug plasma levels or drug treatment failure. Aim. The aim of the study was to review the study of plant medicinal products and drug interactions. Materials and method. Analysis of literature

Plant medicinal products and drug interactions

Introduction. Some herbal medicinal products may be beneficial in certain respects but many can be dangerous for patients taking doctor-prescribed medications. Plant medicinal products are often taken with conventional drugs by patients. Interactions are possible between herbal medicinal products and conventional medications that can lead to toxicity due to increaseddrug plasma levels or drug treatment failure. Aim. The aim of the study was to review the study of plant medicinal products and drug interactions. Materials and method. Analysis of literature

Medicinal benefits from the use of Black pepper, Curcuma and Ginger

Introduction. Black pepper, Curcuma and Ginger are three of the most popular and most frequently used spices. Due to their beneficial medical and pharmacological properties, they are increasingly appreciated phytotheraputic plants. Most of their actions are attributed to their biochemical compositions. Aim. Our intention is to equip the reader with the information and knowledge necessary to understand the role of natural products in the drug discovery process and to enable the assessment of potential benefits and harms of plant-based medicines when advising patients who wish to use them. Material and methods. Analysis of literature. Results. In this paper, we reviewed the use of Black pepper, Curcuma and Ginger documented in the treatment of colds and flu

Plants – a source of therapeutic material?

Introduction. The use of plants with therapeutic or medicinal properties is as ancient as human civilization and for many years prior to the 20th century, plants and animal products were the main source of therapeutic medicinal drugs. Aim. The discovery of new plant-derived drugs continues to be an active field of research in medical science today. The aim of this article is to describe several main classes of natural products currently under investigation. Material and methods. Analysis of literature

Plants – a source of therapeutic material?

Introduction. The use of plants with therapeutic or medicinal properties is as ancient as human civilization and for many years prior to the 20th century, plants and animal products were the main source of therapeutic medicinal drugs. Aim. The discovery of new plant-derived drugs continues to be an active field of research in medical science today. The aim of this article is to describe several main classes of natural products currently under investigation. Material and methods. Analysis of literature

Fundamentals of the use of Berberis as a medicinal plant

Introduction. The daily use of medicinal plants has increased in recent years. The study of drugs of natural origin as an academic discipline and its applications in healthcare has changed remarkably but still focus on the quality of products and the development of new medicines. Aim. This study covers all fundamental aspects of pharmacognosy as well as topics relating to the therapeutic use of plant drugs known as phythotherapy. The purpose of the study was to review the literature about the use of Berberis. Materials and method. We reviewed the literature regarding the use of Berberis published between 1933 and 2018. We found more than 500 articles studying the properties of Berberis for digestive disorders, antibacterial, antidiabetic, hypotensive effects, anti-inflammatory effects, cholesterol regulation, cardiovascular disease, hyperlipidemia, cerebral ischemia trauma, mental disease, Alzheimer disease and osteoporosis. Our review includes recent studies regarding chemical composition and medicinal outcomes of Berberi

The potential of phythotherapy in otorhinolaryngology

Introduction. The objective of this paper is to review the evidence of the use of herbs in phytotherapy. Aim. To discuss plant properties and applications in otorhinolaryngology. Materials and methods. We analysed literature and collected information of phythotherapy in otorhinolaryngology. Results. The databases were searched using various keywords such as phytotherapy, otorhinolaryngology, and herbs such as: echinacea, eucalyptus, garlic, ginkgo, ginseng, kava, pelargonium sidoides, rosemary, spirulina, St John’s wort, and thyme. Conclusions. Due to the beneficial impact of meicinal plants in medicine there is a growing interest in analytical identification and quantification for clinical medicine and forensic toxicology

The potential of phythotherapy in otorhinolaryngology

Introduction. The objective of this paper is to review the evidence of the use of herbs in phytotherapy. Aim. To discuss plant properties and applications in otorhinolaryngology. Materials and methods. We analysed literature and collected information of phythotherapy in otorhinolaryngology. Results. The databases were searched using various keywords such as phytotherapy, otorhinolaryngology, and herbs such as: echinacea, eucalyptus, garlic, ginkgo, ginseng, kava, pelargonium sidoides, rosemary, spirulina, St John’s wort, and thyme. Conclusions. Due to the beneficial impact of meicinal plants in medicine there is a growing interest in analytical identification and quantification for clinical medicine and forensic toxicology