Research on Rutting Model of Semi-Rigid Asphalt Pavement Based on Hamburg Rutting Test

In order to establish a more effective rutting model of semi-rigid asphalt pavement, after sampling on-site,the Hamburg rutting test was conducted to analyze the relationship between ambient temperature, load magnitude,number of load actions and rutting depth; Taking Shami model as a reference,the environmental temperature,load size,load times and asphalt thickness are taken as model parameters;the rutting prediction models of upper,middle and lower surfaces of semi-rigid asphalt pavement structure are established by multiple linear regression analysis,and the models are modified by 6 sections of 4 expressways.The model is used to test 8 sections of 5 expressways,the results show that the average error rate of the calculated value of the model is 15.16%,which is obviously lower than the average error rate of 27.32% of the calculated value of the rut model in the current standard.Therefore,the model has high accuracy and can provide theoretical guidance for the design and maintenance of semi-rigid asphalt pavement

Placental Growth Factor Regulation by Shear Stress and Iron Metabolism in Endothelial Cells

Arteriogenesis is the complex process of outward enlargement of small arteries and arterioles, also known as the collaterals. Arteriogenesis involves cell proliferation and vasculature remodeling and it is induced by increased fluid shear stress (FSS) after occlusion in major arteries upstream. Many cell types, including endothelial cells, smooth muscle cells, monocytes, and endothelial progenitor cells, have been implicated in this process. Previous studies indicate that placental growth factor (PLGF) plays a key role in arteriogenesis by acting as both a cell proliferation inducer and a chemoattractant. Previously, our group has shown that PLGF is mainly produced by endothelial cells. Furthermore, using in vitro and ex vivo models, our group was the first to demonstrate that PLGF is upregulated by FSS, and this process is NADPH oxygenase-4 (NOX-4)- and heme oxygenase-1 (HO-1)-dependent. Furthermore, our group discovered iron, a product of HO-1, can upregulate PLGF. In this study, we demonstrate transcription cofactor p300 as a key regulator in PLGF expression. We discovered that FSS upregulates PLGF by increasing transcription, and p300's histone acetyl transferase (HAT) activity is required in this process. This study identifies epigenetic modification as an important aspect in the complex process of arteriogenesis, and provides important insights for future studies and potential pharmaceutical targets of non-invasive treatments for cardiovascular diseases.Veterinary Biomedical Scienc

A new algorithm for high-precision submarine topography imaging

730-738In this paper, a new algorithm for high-precision submarine topography imaging is proposed. The innovative idea comes from the most effective and widely used instruments: Multibeam echo sounder (MBES) and side scan sonar (SSS). The MBES can acquire bathymetric information with high precision, but its along-track resolution is related to the result of the beam angle multiplied by the slant range. The SSS combined with synthetic aperture sonar technology can achieve a high-precision along-track imaging resolution, but it cannot acquire bathymetric information directly below it. The proposed algorithm uses the beam footprints of the MBES in the along-track direction to perform the aperture synthesis and uses the time-domain and beam-domain imaging algorithms to acquire high-precision along-track imaging resolution and bathymetric information, to improve the along-track resolution and obtain the bathymetric information with high precision at the same time. Finally, an experiment is performed to evaluate the effectiveness of our method. Experimental results demonstrate that two targets, 13 cm in size, can be clearly observed from the obtained imaging. Moreover, their bathymetric information can be calculated by using the beamforming angle information

Discovering conversational topics and emotions associated with Demonetization tweets in India

Social media platforms contain great wealth of information which provides us opportunities explore hidden patterns or unknown correlations, and understand people's satisfaction with what they are discussing. As one showcase, in this paper, we summarize the data set of Twitter messages related to recent demonetization of all Rs. 500 and Rs. 1000 notes in India and explore insights from Twitter's data. Our proposed system automatically extracts the popular latent topics in conversations regarding demonetization discussed in Twitter via the Latent Dirichlet Allocation (LDA) based topic model and also identifies the correlated topics across different categories. Additionally, it also discovers people's opinions expressed through their tweets related to the event under consideration via the emotion analyzer. The system also employs an intuitive and informative visualization to show the uncovered insight. Furthermore, we use an evaluation measure, Normalized Mutual Information (NMI), to select the best LDA models. The obtained LDA results show that the tool can be effectively used to extract discussion topics and summarize them for further manual analysis.Comment: 6 pages, 11 figures. arXiv admin note: substantial text overlap with arXiv:1608.02519 by other authors; text overlap with arXiv:1705.08094 by other author

Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export

We previously showed that mRNAs synthesized from three genes that naturally lack introns contain a portion of their coding sequence, known as a cytoplasmic accumulation region (CAR), which is essential for stable accumulation of the intronless mRNAs in the cytoplasm. The CAR in each mRNA is unexpectedly large, ranging in size from ∼160 to 285 nt. Here, we identified one or more copies of a 10-nt consensus sequence in each CAR. To determine whether this element (designated CAR-E) functions in cytoplasmic accumulation of intronless mRNA, we multimerized the most conserved CAR-E and inserted it upstream of β-globin cDNA, which is normally retained/degraded in the nucleus. Significantly, the tandem CAR-E, but not its antisense counterpart, rescued cytoplasmic accumulation of β-globin cDNA transcripts. Moreover, dinucleotide mutations in the CAR-E abolished this rescue. We show that the CAR-E, but not the mutant CAR-E, associates with components of the TREX mRNA export machinery, the Prp19 complex and U2AF2. Moreover, knockdown of these factors results in nuclear retention of the intronless mRNAs. Together, these data suggest that the CAR-E promotes export of intronless mRNA by sequence-dependent recruitment of the mRNA export machinery