Incidence rates, hazard ratios, and 95% confidence intervals for stroke in relation to quartiles of red cell distribution width.

<p>HR, hazard ratio; py, person-years.</p><p>*Adjusted for systolic and diastolic blood pressure, blood pressure medication, smoking, diabetes, alcohol intake, waist circumference, low physical activity, lipid lowering medication, white blood count, history of atrial fibrillation, and heart failure.</p><p>†Adjusted for * plus mean corpuscular volume and hemoglobin.</p><p>Incidence rates, hazard ratios, and 95% confidence intervals for stroke in relation to quartiles of red cell distribution width.</p

Baseline characteristics by sex-specific quartiles of red cell distribution width (RDW).

<p>Values are given as means±standard deviation (SD) or percentages, unless otherwise stated.B12, vitamin B12; BP, blood pressure; HDL, high density lipoprotein; LDL, low density lipoprotein; MCV, mean corpuscular volume; MDC–CC, Malmö Diet and Cancer–cardiovascular cohort; WBC, white cell blood count.</p><p>*Blood pressure ≥140/90 or BP medication.</p><p>†Men/women >40/>30 g/day.</p><p>‡Geometric mean, p value for comparison of log-transformed values.</p><p>Baseline characteristics by sex-specific quartiles of red cell distribution width (RDW).</p

Association between red cell distribution width (RDW) and total stroke in selected subgroups.

<p>CI, confidence interval; HR, hazard ratio; MCV, mean corpuscular volume.</p><p>*Adjusted for systolic and diastolic blood pressure, blood pressure medication, smoking, diabetes, alcohol intake, waist circumference, low physical activity, lipid lowering medication, white cell blood count, atrial fibrillation and heart failure, mean corpuscular volume, hemoglobin.</p><p>†Hemoglobin <120 g/L for women and <130 for men.</p><p>‡Blood pressure ≥140/90 or current medication.</p><p>Association between red cell distribution width (RDW) and total stroke in selected subgroups.</p

Association between quartiles of red cell distribution width (RDW) and presence of carotid plaque and carotid intima–media thickness.

<p>IMT, intima–media thickness; OR, odds ratio; CI, confidence interval; Beta, beta coefficient from linear regression of log-transformed IMT.</p><p>*Adjusted for age. N = 5,309 for analyses of plaque and IMT–common carotid artery (CCA), and 3,733 for IMT bifurcation.</p><p>†Adjusted for age, systolic and diastolic blood pressure, blood pressure medication, smoking, diabetes, alcohol intake, waist circumference, low physical activity, lipid lowering medication, white cell blood count, history of atrial fibrillation and heart failure, low and high density lipoprotein, triglycerides. N = 4,820 for analyses of plaque and IMT–CCA and 3,393 for IMT bifurcation.</p><p>‡ Adjusted for † plus hemoglobin and mean corpuscular volume. N = 4,820 for analyses of plaque and IMT–CCA and 3,393 for IMT bifurcation.</p><p>Association between quartiles of red cell distribution width (RDW) and presence of carotid plaque and carotid intima–media thickness.</p

Baseline Characteristics of the Study Population.

<p>Values are displayed as means (± standard deviation) or frequency in percent (%). BMI; body mass index; IQR: median and 25–75% interquartile range. Genotype frequencies of rs5068 are presented using a dominant model; major allele represented by AA, G alleles represented by AG+GG.</p

Baseline Characteristics of the Study Population per Each Allele.

<p>Values are displayed as means (± standard deviation) or frequency in percent (%). BMI; body mass index; IQR: median and 25–75% interquartile range.</p

Incidence of diabetes mellitus in relation to sex-specific quartiles of total and differential leukocyte counts in MDC cohort (N = 26 667).

<p>Incidence of diabetes mellitus in relation to sex-specific quartiles of total and differential leukocyte counts in MDC cohort (N = 26 667).</p

Diabetes mellitus free survival in relation to quartiles of total leukocytes in men.

<p>Diabetes mellitus free survival in relation to quartiles of total leukocytes in men.</p

Risk of diabetes occurring in a AA versus AG+GG model of rs5068 allele.

<p>Cumulative incidence of T2D over a mean follow-up of 14 years for major allele (AA) and G allele (AG+GG) of rs5068. * Follow up period in years until first diabetes event, or, for censored cases, death, emigration or last follow up date.</p

The Mendelian randomization path diagram.

<p>The relationship between the instrumental variable R262W, leukocytes (exposure variable), confounding factors and the outcome diabetes.</p