34 research outputs found
PomoÄi žrtvama ratnog nasilja - Ā«Projekt 1 Billion Ā»
Ministarstvo zdravstva i socijalne skrbi Republike Hrvatske sudjeluje u velikom meÄunarodnom projektu usmjerenom ka pomoÄi žrtvama ratnog nasilja. Ā«Projekt 1 Billion Ā» prvi je meÄunarodni Ā projekt posveÄen iskljuÄivo problemu poratnog oporavka stanovniÅ”tva s naglaskom na psihiÄko zdravlje unesreÄene populacije. Procjenjuje se da je preko milijardu ljudi Å”irom svijeta proživjelo tragiÄno iskustvo rata, etniÄkih sukoba i drugih nasilnih konflikata. Preživjele žrtve nasilja Ā i njihove obitelji Ā se Äesto same, ili uz nedovoljnu pomoÄ nacionalnih zdravstvenih sustava i samih oslabljenih ratom, bore s teÅ”kim psihiÄkim traumama. Projekt je i dobio ime po toj milijardi ratom unesreÄenih Ā ljudi
The Metabolic Syndrome - Historical Notice
Godine 1988. Reaven je opisao ulogu
inzulinske rezistencije i hiperinzulinizma i nazvao je "sindrom
X" po kojem se Ŕiroko prepoznaje. Suvremena defi nicija
metaboliÄki sindrom oznaÄava kao skupinu metaboliÄkih
poremeÄaja povezanih sa stanjem inzulinske rezistencije
koji su Äesto povezani s visokim rizikom od fenotipa
prekomjerne težine i pretilosti. MetaboliÄki sindrom je
danas najvažniji izvor novih dijabetiÄnih bolesnika, a isto
tako najveÄi uzrok koronarne bolesti.In 1988, G. Reaven described the role of
insulin resistance and hyperinsulinism and gave it the name
by which it has become widely recognised, "Syndrome X".
A contemporary defi nition of Metabolic Syndrome refers to a
cluster of metabolic disorders related to insulin resistance,
a state that is often associated with a high-risk overweight/
obesity phenotype. Today, metabolic syndrome is the most
important source of new diabetic cases, as well as the
major cause of coronary heart disease
The antioxidative protecting role of the Mediterranean diet [Antioksidativno protektivno djelovanje mediteranske dijete]
Recent meta-analysis shows that adherence to a Mediterranean diet (MD) can significantly decrease the risk of overall mortality, mortality from cardiovascular diseases, as well as incidence of mortality from cancer, and incidence of Parkinson's and Alzheimer's disease. All of these diseases could be linked to oxidative stress (OS) as antioxidative effect of MD is getting more attention nowadays. Although a lot of research has been done in this area and it suggests antioxidative protective role of MD, the presented evidence is still inconclusive. The aim of this paper is to review studies investigating the effect of MD on OS, as well as to identify the areas for further research
The Jubilees of the Discovery of Insulin & Glycemic Index: Where Conventional meets Complementary Medicine in the Management of Diabetes Mellitus
This year we marked two important jubilees in the management of diabetes mellitus: one is the discovery of insulin 90
years ago and the other one is the introduction of the Glycemic Index, 60 years later, both originated at the University of
Toronto, Canada. Both discoveries can help to improve diabetes tremendously and thus have contributed to the advancement
of management of this troubling disease the incidence of which continues to climb at a staggering rate
Red blood cell distribution width as a prognostic marker of mortality in patients on chronic dialysis: a single center, prospective longitudinal study
Aim To determine if red cell distribution width (RDW) is associated
with all-cause mortality in patients on chronic dialysis
and to evaluate its prognostic value among validated
prognostic biomarkers.
Methods This is a single center, prospective longitudinal
study. At the time of inclusion in January 2011, all patients
were physically examined and a routine blood analysis was
performed. A sera sample was preserved for determination
of NT-pro-brain natriuretic peptide (NT-pro-BNP) and eosinophil
cationic protein. Carotid intima media thickness
(IMT) was also measured. Following one year, all-cause
mortality was evaluated.
Results Of 100 patients, 25 patients died during the follow-
up period of one-year. Patients who died had significantly
higher median [range] RDW levels (16.7% [14.3-19.5]
vs 15.5% [13.2-19.7], P < 0.001. They had significantly higher
Eastern Cooperative Oncology Group (ECOG) performance
status (4 [2-4] vs 2 [1-4], P < 0.001), increased intima-media
thickness (IMT) (0.71 [0.47-1.25] vs 0.63 [0.31-1.55], P = 0.011),
increased NT-pro-BNP levels (8300 [1108-35000] vs 4837
[413-35000], P = 0.043), and increased C-reactive protein
(CRP) levels (11.6 [1.3-154.2] vs 4.9 [0.4-92.9], P < 0.001). For
each 1% point increase in RDW level as a continuous variable,
one-year all cause mortality risk was increased by 54%
in univariate Cox proportional hazard analysis. In the final
model, when RDW was entered as a categorical variable,
mortality risk was significantly increased (hazard ratio, 5.15,
95% confidence interval, 2.33 to 11.36) and patients with
RDW levels above 15.75% had significantly shorter survival
time (Log rank P < 0.001) than others.
Conclusions RDW could be an additive predictor for allcause
mortality in patients on chronic dialysis. Furthermore,
RDW combined with sound clinical judgment improves
identification of patients who are at increased risk
compared to RDW alone
Carotid Endarterectomy Unexpectedly Resulted in Optimal Blood Pressure Control
Resistant hypertension is defined as hypertension that remains above 140/90 mmHg despite the provision of three or more antihypertensive drugs in a rational combination at full doses and including a diuretic. It is associated with adverse clinical outcome and therefore requires aggressive medical treatment. We present a case of 70-year-old woman who was treated for resistant hypertension with a diuretic, ACE-inhibitor, calcium channel blocker, and with centrally acting antihypertensive, moxonodine. Despite of aggressive medical treatment her blood pressure remained above 160/90 mmHg continuously. Large diagnostic workup excluded common causes of secondary hypertension, but revealed significant carotid stenosis present on left internal carotid artery. Carotid endarterectomy was performed in order to improve cerebrovascular prognosis, but unexpectedly resulted in optimal control of her blood pressure. Two months after operation patient was on only one antihypertensive drug, having blood pressure below 130/85 mmHg. We suggest that in selected patients resistant hypertension could be associated with carotid stenosis and carotid sinus baroreceptor dysfunction. For definite conclusions further studies are warranted