59 research outputs found
Factors Relevant to Intensive and Extensive EFL Reading Programs in Japan--Problems and Solutions. The Role of Translation
Get PDFA Historical Perspective on Japanese Language Policy--Towards the Ainu Minority Language and its Relationshipto Policies of Colonial Expansion and the Concept of Ethno-linguistic "Purity"
Get PDFLecture: MIND THE GAP!--On the Nature of \u27Rabbit Holes\u27 or Communication Gaps Experienced by a Westerner on First Arriving in Japan
Get PDFUsing the Internet as an EFL Teaching Resource for Japanese Learners at University Level:A Practical Illustration of 4-skills Project Work
Get PDFA Study of the Relevance of Linguistic Relativity Theory as an Effective Tool for Engineering Feminist Social Change in Japan. Differences in Oriental/Occidental Attitudes towards Achieving such a Change and Factors that might Influence its Successful Achievement
Get PDFPresentation Panel on Metadata Standards
Get PDFExamples of topics of interest- Why do we need metadata standards development? How are standards developed? Given the lack of agreed upon standards for 3D data, what solutions are institutions currently using? What are users’ needs regarding metadata? Who are the targeted users? What constitutes the minimal metadata for inclusion in a repository? How can linked metadata be developed for improved workflows. What would be required for data clean up or migration for previously unstandardized data
DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.
Get PDFXRCC4 and XLF are two structurally related proteins that function in DNA double-strand break (DSB) repair. Here, we identify human PAXX (PAralog of XRCC4 and XLF, also called C9orf142) as a new XRCC4 superfamily member and show that its crystal structure resembles that of XRCC4. PAXX interacts directly with the DSB-repair protein Ku and is recruited to DNA-damage sites in cells. Using RNA interference and CRISPR-Cas9 to generate PAXX(-/-) cells, we demonstrate that PAXX functions with XRCC4 and XLF to mediate DSB repair and cell survival in response to DSB-inducing agents. Finally, we reveal that PAXX promotes Ku-dependent DNA ligation in vitro and assembly of core nonhomologous end-joining (NHEJ) factors on damaged chromatin in cells. These findings identify PAXX as a new component of the NHEJ machinery.T.O. and T.L.B. are supported by the Wellcome Trust. The Jackson lab is funded by Cancer
Research UK (CRUK) program grant C6/A11224, the European Research Council and the
European Community Seventh Framework Programme grant agreement no. HEALTH-F2-2010-
259893 (DDResponse). Core infrastructure funding to the Jackson lab is provided by CRUK
(C6946/A14492) and the Wellcome Trust (WT092096). S.P.J. receives his salary from the
University of Cambridge, supplemented by CRUK. V.M.D. is a CRUK Career Development Fellow. The Draviam lab is funded by a CRUK CDA (C28598/A9787).This is the accepted manuscript version. The final version is available from AAAS at http://www.sciencemag.org/content/347/6218/185.full
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