4,166 research outputs found
Making Work Pay II: Comprehensive Health Insurance for Low-Income Working Families
Assesses the lack of health insurance and poor health among low-income families, and outlines a strategy to address their healthcare needs by expanding coverage through state-based purchasing pools, subsidies, an individual mandate, and cost containment
From Publish or Perish to Profit or Perish: Revenues from University Technology Transfer and the 501(c)(3) Tax Exemption
Anharmonicity and self-energy effects of the E2g phonon in MgB2
We present a Raman scattering study of the E2g phonon anharmonicity and of
superconductivity induced self-energy effects in MgB2 single crystals. We show
that anharmonic two phonon decay is mainly responsible for the unusually large
linewidth of the E2g mode. We observe ~ 2.5 % hardening of the E2g phonon
frequency upon cooling into the superconducting state and estimate the
electron-phonon coupling strength associated with this renormalization.Comment: 4 pages, 3 figures, accepted to PR
Successfully controlling malaria in South Africa
PKFollowing major successes in malaria control over the past 75 years, South Africa is now embarking on a malaria elimination campaign with the goal of zero local transmission by the year 2018. The key control elements have been intensive vector control, primarily through
indoor residual spraying, case management based on parasitological diagnosis using evidence-based drug policies with artemisinin-based combination therapy since 2001, active health promotion in partnership with communities living in the malaria transmission areas,
and cross-border collaborations. Political commitment and long-term funding for the malaria control programme have been a critical component of the programme’s success. Breaking the cycle of transmission through strengthening of active surveillance using sensitive
molecular tests and field treatment of asymptomatic persons, monitoring for antimalarial drug resistance and insecticide resistance, strengthening cross-border initiatives, and ongoing programme advocacy in the face of a significant decrease in disease burden are key
priorities for achieving the elimination goal
Active repression by unliganded retinoid receptors in development: less is sometimes more
The retinoid receptors have major roles throughout development, even in the absence of ligand. Here, we summarize an emerging theme whereby gene repression, mediated by unliganded retinoid receptors, can dictate cell fate. In addition to activating transcription, retinoid receptors actively repress gene transcription by recruiting cofactors that promote chromatin compaction. Two developmental processes for which gene silencing by the retinoid receptors is essential are head formation in Xenopus and skeletal development in the mouse. Inappropriate repression, by oncogenic retinoic acid (RA)* receptor (RAR) fusion proteins, blocks myeloid differentiation leading to a rare form of leukemia. Our current understanding of the developmental role of retinoid repression and future perspectives in this field are discussed
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