Extending the relational model with uncertainty and ignorance

It has been widely recognized that in many real-life database applications there is growing demand to model uncertainty and ignorance. However the relational model does not provide this possibility. Through the years a number of efforts has been devoted to the capture of uncertainty and ignorance in databases. Most of these efforts attempted to capture uncertainty using the classic probability theory. As a consequence, the limitations of probability theory are inherited by these approaches, such as the problem of information loss. In this paper, we extend the relational model with uncertainty and ignorance without these limitations posed by the other approaches. Our approach is based on the so-called theory of belief functions, which may be considered as a generalization of probability theory. Belief functions have an attractive mathematical\ud underpinning and many intuitively appealing properties

Utilizing Structural Knowledge for Information Retrieval in XML Databases

In this paper we address the problem of immediate translation of eXtensible Mark-up Language (XML) information retrieval (IR) queries to relational database expressions and stress the benefits of using an intermediate XML-specific algebra over relational algebra. We show how adding an XML-specific algebra at the logical level of a DBMS enables a level of abstraction from both query languages for information retrieval in XML and the underlying physical storage and manipulation. We picked a region algebra as a basis for defining the structure aware (SA) view on XML in which we can distinguish among different XML entities, such as element nodes, text nodes, words, and determine their containment relation. Region algebras are already well established in semi-structured document processing as shown in an extensive overview of region algebra approaches in this paper. Furthermore, we propose a variant of region algebra that can support ranking operators in an elegant way while staying algebraic. As relevance scores are computed for regions in our region algebra we named it score region algebra (SRA). The benefits of introducing score region algebra are explained on a set of query examples. Besides abstracting from the query language used and the physical implementation, SRA enables a certain degree of abstraction from the retrieval model used and the opportunity to use the query optimization at the logical level of a database. Various retrieval models can be instantiated at the physical level based on the abstract specification of SRA operators. We also discuss numerous region algebra operator properties that provide a firm ground for query rewriting and optimization at the SA level, which is an important premise for the existence of such a logical view on XML

Moa: extensibility and efficiency in querying nested data

Advanced non-traditional application domains such as geographic information systems and digital library systems demand advanced data management support. In an effort to cope with this demand, we present a novel multi-model DBMS architecture which provides efficient evaluation of queries on complexly structured data. A vital role in this architecture is played by the Moa language featuring a nested relational data model based on XNF2, in which we placed renewed interest. Furthermore, the architecture allows extensibility on all of its levels providing the means to better integrate domain-specific algorithms into the system. In addition to this, the extensibility of the Moa language is designed in a way that optimization obstacles due to blackbox treatment of ADTs is avoided. This combination of well-integrated domainspecific algorithms, extensibility open to optimization, and a mapping of queries on complexly structured data to an efficient physical algebra expression via a nested relational algebra, makes that the Moa system can efficiently handle complex queries from non-traditional application domains

CIRQUID: complex information retrieval queries in a database

The CIRQUID project plans to design and build a DBMS that seemlessly integrates relevance-oriented querying of semi-structured data (XML) with traditional querying of this data. The project is funded by the Netherlands Organisation of Scientific Research

Ultrasound imaging of the rabbit peroneal nerve

Ultrasound imaging of peripheral nerves is increasingly used in the clinic for a wide range of applications. Although yet unapplied for experimental neuroscience, it also has potential value in this research area. This study explores the feasibility, possibilities and limitations of this technique in rabbits, with special focus on peripheral nerve regeneration after trauma. The peroneal nerve of 25 New Zealand White rabbits was imaged at varying time intervals after a crush lesion. The ultrasonic appearance of the nerve was determined, and recordings were validated with in vivo anatomy. Nerve swelling at the lesion site was estimated from ultrasound images and compared with anatomical parameters. The peroneal nerve could reliably be identified in all animals, and its course and anatomical variations agreed perfectly with anatomy. Nerve diameters from ultrasound were related to in vivo diameters (p < 0.001, R2 = 77%), although the prediction interval was rather wide. Nerve thickenings could be visualized and preliminary results indicate that ultrasound can differentiate between neuroma formation and external nerve thickening. The value of the technique for experimental neuroscience is discussed. We conclude that ultrasound imaging of the rabbit peroneal nerve is feasible and that it is a promising tool for different research areas within the field of experimental neuroscience

U, B and r band luminosity functions of galaxies in the Coma cluster

We present a deep multi-colour CCD mosaic of the Coma cluster (Abell 1656), covering 5.2 deg^2 in the B and r bands, and 1.3 deg^2 in the U band. This large, homogeneous data set provides a valuable low redshift comparison sample for studies of galaxies in distant clusters. In this paper we present our survey, and study the dependence of the galaxy luminosity function (LF) on passband and radial distance from the cluster centre. The U, B and r band LFs of the complete sample cannot be represented by single Schechter functions. For the central area, r<245 h_{100}^{-1} kpc, we find best-fitting Schechter parameters of M^{*}_U=-18.60^{+0.13}_{-0.18} and \alpha_U=-1.32^{+0.018}_{-0.028}, M^{*}_B=-19.79^{+0.18}_{-0.17} and \alpha_B=-1.37^{+0.024}_{-0.016} and M^{*}_r=-20.87^{+0.12}_{-0.17} and \alpha_r=-1.16^{+0.012}_{-0.019}. The LF becomes steeper at larger radial distance from the cluster centre. The effect is most pronounced in the U band. This result is consistent with the presence of a star forming dwarf population at large distance from the cluster centre, which may be in the process of being accreted by the cluster. The shapes of the LFs of the NGC 4839 group support a scenario in which the group has already passed through the centre.Comment: Accepted for publication in MNRA

Chromatic periodic activity down to 120 MHz in a Fast Radio Burst

Fast radio bursts (FRBs) are extragalactic astrophysical transients whose brightness requires emitters that are highly energetic, yet compact enough to produce the short, millisecond-duration bursts. FRBs have thus far been detected between 300 MHz and 8 GHz, but lower-frequency emission has remained elusive. A subset of FRBs is known to repeat, and one of those sources, FRB 20180916B, does so with a 16.3 day activity period. Using simultaneous Apertif and LOFAR data, we show that FRB 20180916B emits down to 120 MHz, and that its activity window is both narrower and earlier at higher frequencies. Binary wind interaction models predict a narrower periodic activity window at lower frequencies, which is the opposite of our observations. Our detections establish that low-frequency FRB emission can escape the local medium. For bursts of the same fluence, FRB 20180916B is more active below 200 MHz than at 1.4 GHz. Combining our results with previous upper-limits on the all-sky FRB rate at 150 MHz, we find that there are 3-450 FRBs/sky/day above 50 Jy ms at 90% confidence. We are able to rule out the scenario in which companion winds cause FRB periodicity. We also demonstrate that some FRBs live in clean environments that do not absorb or scatter low-frequency radiation.Comment: 50 pages, 14 figures, 3 tables, submitte

Brain-homing CD4+ T cells display glucocorticoid-resistant features in MS

Objective To study whether glucocorticoid (GC) resistance delineates disease-relevant T helper (Th) subsets that home to the CNS of patients with early MS. Methods The expression of key determinants of GC sensitivity, multidrug resistance protein 1 (MDR1/ ABCB1) and glucocorticoid receptor (GR/NR3C1), was investigated in proinflammatory Th subsets and compared between natalizumab-treated patients with MS and healthy individuals. Blood, CSF, and brain compartments from patients with MS were assessed for t

Modulation of innate immune responses at birth by prenatal malaria exposure and association with malaria risk during the first year of life.

BACKGROUND: Factors driving inter-individual differences in immune responses upon different types of prenatal malaria exposure (PME) and subsequent risk of malaria in infancy remain poorly understood. In this study, we examined the impact of four types of PME (i.e., maternal peripheral infection and placental acute, chronic, and past infections) on both spontaneous and toll-like receptors (TLRs)-mediated cytokine production in cord blood and how these innate immune responses modulate the risk of malaria during the first year of life. METHODS: We conducted a birth cohort study of 313 mother-child pairs nested within the COSMIC clinical trial (NCT01941264), which was assessing malaria preventive interventions during pregnancy in Burkina Faso. Malaria infections during pregnancy and infants' clinical malaria episodes detected during the first year of life were recorded. Supernatant concentrations of 30 cytokines, chemokines, and growth factors induced by stimulation of cord blood with agonists of TLRs 3, 7/8, and 9 were measured by quantitative suspension array technology. Crude concentrations and ratios of TLR-mediated cytokine responses relative to background control were analyzed. RESULTS: Spontaneous production of innate immune biomarkers was significantly reduced in cord blood of infants exposed to malaria, with variation among PME groups, as compared to those from the non-exposed control group. However, following TLR7/8 stimulation, which showed higher induction of cytokines/chemokines/growth factors than TLRs 3 and 9, cord blood cells of infants with evidence of past placental malaria were hyper-responsive in comparison to those of infants not-exposed. In addition, certain biomarkers, which levels were significantly modified depending on the PME category, were independent predictors of either malaria risk (GM-CSF TLR7/8 crude) or protection (IL-12 TLR7/8 ratio and IP-10 TLR3 crude, IL-1RA TLR7/8 ratio) during the first year of life. CONCLUSIONS: These findings indicate that past placental malaria has a profound effect on fetal immune system and that the differential alterations of innate immune responses by PME categories might drive heterogeneity between individuals to clinical malaria susceptibility during the first year of life

The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production

Abstract Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described