Performance behaviour in elite sports

To win that one final, to be the best in the world or to become an Olympic champion. That is what high-potential and elite athletes train for. Every day and for many years. The way to get there is dynamic and complex, and full of challenges athletes need to handle. To effectively deal with the challenges this rocky road throws at them, athletes require performance behaviour. Performance behaviour reflects the athlete’s actual behaviour in all situations he is confronted with on a day-to-day basis. It leads to optimal development and a maximum level of performance in sport. To enhance athletes’ performance behaviour, they should develop psychological competencies. This dissertation provides insight in the psychological competencies that high-potential and world-class athletes require to deal with the challenges they face in different stages of their athletic career. Yet unanswered questions are studied, such as: what are the perceived challenges high-potential and elite athletes are confronted with throughout their athletic career? What psychological competencies do they need to deal with the challenges of their athletic career? Are those psychological competencies the same in each of the stages of athletic development? And how can coaches assess the psychological competencies of their athletes? Being the first to study the competencies of performance behaviour, Suzan Blijlevens’ dissertation shows that high-potential and elite athletes in different stages of their athletic career are confronted with partly similar and partly different challenges. As a consequence, the need and importance of the possession of specific psychological competencies changes throughout the athletic career. This dissertation revealed a number of recommendations for those responsible for athletes’ development (e.g. coaches, sport psychologists and other support staff). The practical output of this dissertation is among others an observation tool performance behaviour and a learning line for TeamNL, which now will be further optimized and implemented

Prediction of future car forms based on historical trends

SummaryCars are one of the most important products that affects our daily life. Manufacturers of cars are inclined to know factors that affect the sales of cars and how to influence them. Car is a very competitive product whose technology is already matured. Thus, purchase decisions of a car depend on factors such as, aesthetics, ergonomics, features available and price. Exterior form and colour of a car are the most important factors that influence likeness of the car. We did a case study on car aesthetics (form, colour, shape, and user focus) with more than 500 car advertisements over the past 70 years, appearing in various car magazines. Results show that form of cars has changed from sharp to smooth over the years, and white colour cars are becoming more popular. Additionally, car size is becoming smaller and increasingly focused towards family. Thus, manufacturers are recommended to develop compact, efficient and hybrid cars

Searching for the 'sweet-spot': Demonstrating the contribution of shape analysis tools in stimuli creation

Within design research several well-known principles have been identified that influence aesthetic pleasure for product designs. More specifically, these design principles indicate an optimal balance on a certain design attribute that receives the highest aesthetic pleasure (e.g., Most Advanced, Yet Acceptable). While these go far in explaining the effects of design on appraisal, the nature of the stimuli used in these studies makes it difficult to identify exactly where this optimal balance lies and thus does not inform a designer on how to adjust a given attribute to create an aesthetically pleasing product design. In this study, we conduct a meta analysis on one such study exploring the design principle Most Advanced, Yet Acceptable and demonstrate the application of shape comparison tools in relating the sweet-spot in terms of changes in product shape. Results from the application show the way in which quantifying difference in shape can help to identify aspects of shape where minor changes result in substantial increases/decreases in aesthetic pleasure, as well as its use in relating a value of difference to optimum values of aesthetic pleasure

Acquisition and maintenance of excellence:the challenges faced by Dutch top-level gymnasts throughout different stages of athletic development

The purpose of the present study is to identify the within-career challenges top-level gymnasts experience during the initiation, development and mastery stage of athletic development in training sessions, competition, and in daily life. In-depth interviews are used to explore the perceived challenges of 16 talented and elite gymnasts (M = 16.5 years, SD = 4.6 years). Participants are divided into three groups, according to the stage of their athletic development. Several challenges are perceived in all stages of athletic development (e.g. learning new elements, dealing with stress under pressure, dealing with distractions and managing their dual career). As the number of different challenges increases as the gymnasts reach the mastery stage, challenges seem to become more personal and specific than in previous stages. The study shows obvious differences in the nature of the perceived challenges for different stages of athletic development, which provides useful insights for those who work with talented and elite athletes

The potential of individualized dosing of ravulizumab to improve patient-friendliness of paroxysmal nocturnal haemoglobinuria treatment at reduced costs

Contains fulltext : 237767.pdf (Publisher’s version ) (Open Access)Ravulizumab is a very expensive complement C5-inhibitor for the treatment of paroxysmal nocturnal haemoglobinuria, with a fixed-dosing interval of 8 weeks. For lifelong treatment, a cost-effective and patient-friendly dosing strategy is preferred. We therefore explored alternative ravulizumab dosing regimens in silico based on the thorough dose-finding studies of the manufacturer. Extending the interval to 10 weeks or individually extending the interval to a mean of 12.8 weeks based on pharmacokinetic monitoring resulted in noninferior efficacy in terms of lactate dehydrogenase normalization, with drug cost savings up to 37%. We here show the potential of individualized ravulizumab dosing to improve patient-friendliness at reduced costs

18F-FDG PET/CT for diagnosing infectious complications in patients with severe neutropenia after intensive chemotherapy for haematological malignancy or stem cell transplantation

Item does not contain fulltextPURPOSE: Between 30 and 50% of febrile neutropenic episodes are accounted for by infection. C-reactive protein (CRP) is a nonspecific parameter for infection and inflammation but might be employed as a trigger for diagnosis. The aim of the study was to evaluate whether (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT can be used to detect inflammatory foci in neutropenic patients with elevated CRP and whether it helps to direct treatment. METHODS: Twenty-eight consecutive patients with neutropenia as a result of intensive chemotherapy for haematological malignancies or myeloablative therapy for haematopoietic stem cell transplantation were prospectively included. (18)F-FDG PET/CT was added to the regular diagnostic workup once the CRP level rose above 50 mg/l. RESULTS: Pathological FDG uptake was found in 26 of 28 cases despite peripheral neutrophil counts less than 0.1 x 10(-9)/l in 26 patients: in the digestive tract in 18 cases, around the tract of the central venous catheter (CVC) in 9 and in the lungs in 7 cases. FDG uptake in the CVC tract was associated with coagulase-negative staphylococcal bacteraemia (p < 0.001) and deep venous thrombosis (p = 0.002). The number of patients having Streptococcus mitis bacteraemia appeared to be higher in patients with grade 3 oesophageal FDG uptake (p = 0.08). Pulmonary FDG uptake was associated with the presence of invasive fungal disease (p = 0.04). CONCLUSION: (18)F-FDG PET/CT scanning during chemotherapy-induced febrile neutropenia and increased CRP is able to detect localized foci of infection and inflammation despite the absence of circulating neutrophils. Besides its potential role in detecting CVC-related infection during febrile neutropenia, the high negative predictive value of (18)F-FDG PET/CT is important for avoiding unnecessary diagnostic tests and therapy.1 januari 201

A rare case of supraspinatus tendon rupture

Item does not contain fulltext1 januari 201

Intestinal Damage Determines the Inflammatory Response and Early Complications in Patients Receiving Conditioning for a Stem Cell Transplantation

Contains fulltext : 87954.pdf (publisher's version ) (Open Access)BACKGROUND: Stem cell transplantation (SCT) is still complicated by the occurrence of fever and inflammatory complications attributed to neutropenia and subsequent infectious complications. The role of mucosal barrier injury (MBI) of the intestinal tract therein has received little attention. METHODS: We performed a retrospective analysis in 163 SCT recipients of which data had been collected prospectively on intestinal damage (citrulline), inflammation (C-reactive protein), and neutrophil count. Six different conditioning regimens were studied; 5 myeloablative (MA) and 1 non-myeloablative (NMA). Linear mixed model multivariate and AUC analyses were used to define the role of intestinal damage in post-SCT inflammation. We also studied the relationship between the degree of intestinal damage and the occurrence of early post-SCT complications. RESULTS: In the 5 MA regimen there was a striking pattern of inflammatory response that coincided with the occurrence of severe intestinal damage. This contrasted with a modest inflammatory response seen in the NMA regimen in which intestinal damage was limited. With linear mixed model analysis the degree of intestinal damage was shown the most important determinant of the inflammatory response, and both neutropenia and bacteremia had only a minor impact. AUC analysis revealed a strong correlation between citrulline and CRP (Pearson correlation r = 0.96). Intestinal damage was associated with the occurrence of bacteremia and acute lung injury, and influenced the kinetics of acute graft-versus-host disease. CONCLUSION: The degree of intestinal damage after myeloablative conditioning appeared to be the most important determined the inflammatory response following SCT, and was associated with inflammatory complications. Studies should explore ways to ameliorate cytotoxic therapy-induced intestinal damage in order to reduce complications associated with myeloablative conditioning therapy

The effectiveness of ibrutinib in chronic lymphocytic leukaemia: a nationwide, population-based study in the Netherlands

Contains fulltext : 218321.pdf (Publisher’s version ) (Closed access