Mesoscopic Mechanical Resonators as Quantum Non-Inertial Reference Frames

An atom attached to a micrometer-scale wire that is vibrating at a frequency of 100 MHz and with displacement amplitude 1 nm experiences an acceleration magnitude 10^9 ms^-2, approaching the surface gravity of a neutron star. As one application of such extreme non-inertial forces in a mesoscopic setting, we consider a model two-path atom interferometer with one path consisting of the 100 MHz vibrating wire atom guide. The vibrating wire guide serves as a non-inertial reference frame and induces an in principle measurable phase shift in the wave function of an atom traversing the wire frame. We furthermore consider the effect on the two-path atom wave interference when the vibrating wire is modeled as a quantum object, hence functioning as a quantum non-inertial reference frame. We outline a possible realization of the vibrating wire, atom interferometer using a superfluid helium quantum interference setup.Comment: Published versio

Phonon-mediated thermal conductance of mesoscopic wires with rough edges

We present an analysis of acoustic phonon propagation through long, free-standing, insulating wires with rough surfaces. Due to a crossover from ballistic propagation of the lowest-frequency phonon mode at $\omega <\omega _{1}=\pi c/W$ to a diffusive (or even localized) behavior upon the increase of phonon frequency, followed by re-entrance into the quasi-ballistic regime, the heat conductance of a wire acquires an intermediate tendency to saturate within the temperature range $T\sim \hbar \omega_{1}/k_{B}$.Comment: 4 pages, 3 figures included; minor changes and corrections, figures 1 and 2 replaced by better versions; to appear in PRB Brief Report

Titanium dioxide nanoparticles as radiosensitisers: An in vitro and phantom-based study

Objective: Radiosensitisation caused by titanium dioxide nanoparticles (TiO2-NPs) is investigated using phantoms (PRESAGE® dosimeters) and in vitro using two types of cell lines, cultured human keratinocyte (HaCaT) and prostate cancer (DU145) cells. Methods: Anatase TiO2-NPs were synthesised, characterised and functionalised to allow dispersion in culture-medium for in vitro studies and halocarbons (PRESAGE® chemical compositions). PRESAGE® dosimeters were scanned with spectrophotometer to determine the radiation dose enhancement. Clonogenic and cell viability assays were employed to determine cells survival curves from which the dose enhancement levels &quot;radiosensitisation&quot; are deduced. Results: Comparable levels of radiosensitisation were observed in both phantoms and cells at kilovoltage ranges of x-ray energies (slightly higher in vitro). Significant radiosensitisation (~67 %) of control was also noted in cells at megavoltage energies (commonly used in radiotherapy), compared to negligible levels detected by phantoms. This difference is attributed to biochemical effects, specifically the generation of reactive oxygen species (ROS) such as hydroxyl radicals (•OH), which are only manifested in aqueous environments of cells and are non-existent in case of phantoms. Conclusions: This research shows that TiO2-NPs improve the efficiency of dose delivery, which has implications for future radiotherapy treatments. Literature shows that Ti2O3-NPs can be used as imaging agents hence with these findings renders these NPs as theranostic agents

Quantum nano-electromechanics with electrons, quasiparticles and Cooper pairs: effective bath descriptions and strong feedback effects

Using a quantum noise approach, we discuss the physics of both normal metal and superconducting single electron transistors (SET) coupled to mechanical resonators. Particular attention is paid to the regime where transport occurs via incoherent Cooper-pair tunneling (either via the Josephson quasiparticle (JQP) or double Josephson quasiparticle (DJQP) process). We show that, surprisingly, the back-action of tunneling Cooper pairs (or superconducting quasiparticles) can be used to significantly cool the oscillator. We also discuss the physical origin of negative damping effects in this system, and how they can lead to a regime of strong electro-mechanical feedback, where despite a weak SET - oscillator coupling, the motion of the oscillator strongly effects the tunneling of the Cooper pairs. We show that in this regime, the oscillator is characterized by an energy-dependent effective temperature. Finally, we discuss the strong analogy between back-action effects of incoherent Cooper-pair tunneling and ponderomotive effects in an optical cavity with a moveable mirror; in our case, tunneling Cooper pairs play the role of the cavity photons.Comment: 27 pages, 7 figures; submitted to the New Journal of Physics focus issue on Nano-electromechanical Systems; error in references correcte

Closed-Flux Solutions to the Constraints for Plane Gravity Waves

The metric for plane gravitational waves is quantized within the Hamiltonian framework, using a Dirac constraint quantization and the self-dual field variables proposed by Ashtekar. The z axis (direction of travel of the waves) is taken to be the entire real line rather than the torus (manifold coordinatized by (z,t) is RxR rather than $S_1$ x R). Solutions to the constraints proposed in a previous paper involve open-ended flux lines running along the entire z axis, rather than closed loops of flux; consequently, these solutions are annihilated by the Gauss constraint at interior points of the z axis, but not at the two boundary points. The solutions studied in the present paper are based on closed flux loops and satisfy the Gauss constraint for all z.Comment: 18 pages; LaTe

Modelling stillbirth mortality reduction with the Lives Saved Tool.

BACKGROUND: The worldwide burden of stillbirths is large, with an estimated 2.6 million babies stillborn in 2015 including 1.3 million dying during labour. The Every Newborn Action Plan set a stillbirth target of ≤12 per 1000 in all countries by 2030. Planning tools will be essential as countries set policy and plan investment to scale up interventions to meet this target. This paper summarises the approach taken for modelling the impact of scaling-up health interventions on stillbirths in the Lives Saved tool (LiST), and potential future refinements. METHODS: The specific application to stillbirths of the general method for modelling the impact of interventions in LiST is described. The evidence for the effectiveness of potential interventions to reduce stillbirths are reviewed and the assumptions of the affected fraction of stillbirths who could potentially benefit from these interventions are presented. The current assumptions and their effects on stillbirth reduction are described and potential future improvements discussed. RESULTS: High quality evidence are not available for all parameters in the LiST stillbirth model. Cause-specific mortality data is not available for stillbirths, therefore stillbirths are modelled in LiST using an attributable fraction approach by timing of stillbirths (antepartum/ intrapartum). Of 35 potential interventions to reduce stillbirths identified, eight interventions are currently modelled in LiST. These include childbirth care, induction for prolonged pregnancy, multiple micronutrient and balanced energy supplementation, malaria prevention and detection and management of hypertensive disorders of pregnancy, diabetes and syphilis. For three of the interventions, childbirth care, detection and management of hypertensive disorders of pregnancy, and diabetes the estimate of effectiveness is based on expert opinion through a Delphi process. Only for malaria is coverage information available, with coverage estimated using expert opinion for all other interventions. Going forward, potential improvements identified include improving of effectiveness and coverage estimates for included interventions and addition of further interventions. CONCLUSIONS: Known effective interventions have the potential to reduce stillbirths and can be modelled using the LiST tool. Data for stillbirths are improving. Going forward the LiST tool should seek, where possible, to incorporate these improving data, and to continually be refined to provide an increasingly reliable tool for policy and programming purposes

Quantum Nondemolition Measurement of Discrete Fock States of a Nanomechanical Resonator

We study theoretically a radio frequency superconducting interference device integrated with a nanomechanical resonator and an LC resonator. By applying adiabatic and rotating-wave approximations, we obtain an effective Hamiltonian that governs the dynamics of the mechanical and LC resonators. Nonlinear terms in this Hamiltonian can be exploited for performing a quantum nondemolition measurement of Fock states of the nanomechanical resonator. We address the feasibility of experimental implementation and show that the nonlinear coupling can be made sufficiently strong to allow the detection of discrete mechanical Fock states

Intermodulation and Parametric Amplification in a Superconducting Stripline Resonator Integrated with a dc-SQUID

We utilize a superconducting stripline resonator containing a dc-SQUID as a strong intermodulation amplifier exhibiting a signal gain of 24dB and a phase modulation of 30dB. Studying the system response in the time domain near the intermodulation amplification threshold reveals a unique noise-induced spikes behavior. We account for this response qualitatively via solving numerically the equations of motion for the integrated system. Furthermore, employing this device as a parametric amplifier yields an abrupt rise of 38dB in the generated side-band signal