Sertoliform cystadenoma: a rare benign tumour of the rete testis

Abstract Sertoliform cystadenoma of the rete testis represents an uncommon benign tumour. They appear in patients from 26 to 62 years of age. We describe a case of a 66-year-old man with a tumour in the area of the epididymal head. The tumour markers were not increased. Under the assumption of a malignant testicular tumour an inguinal orchiectomy was performed. The cut surface of this tumour was of grey/white color and showed small cysts. The tumour consisted of two compartments. The epithelial like tumour cells showed a sertoliform growth pattern and cystic dilatations. In between the tumour cells repeatedly actin expressing sclerotic areas could be recognized as the second tumour component. Proliferative activity was not increased. Immunohistochemically the tumour cells were positiv for inhibin, S-100, and CD 99. Alpha feto protein (AFP), human chorionic gonadotropin (ß-HCG) and placental alkaline phosphatase (PLAP) as well as synaptophysin, epithelial membrane antigene (EMA), and BCL-2 were not expressed. As far as we know this is the sixth reported case of this tumour. Because of the benign nature of this tumour the correct diagnosis is important for the intra- and postoperative management. Here we present a case of this rare tumour and discuss potential differential diagnosis. Virtual Slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1956026143857335</p

SURESOFT workshop series

Researchers develop software to process or generate data to test their scientific hypotheses. Especially researchers from STEM disciplines (Science, Technology, Engineering, and Mathematics) validate their models through self-developed software prototypes. However, they do not necessarily have a programming or software engineering background. Moreover, scientific software development happens in a time-constrained environment focusing on the fast publication of results. In addition, as scientists usually have limited contracts, the software is developed with short-term goals in mind. Therefore, the resulting software is mostly rapidly developed and contains code artifacts that are hard to maintain, extend and even reproduce due to missing documentation or dependencies. These factors, among others, hinder researchers from progressing and further developing their software. Thus, research software sustainability is vital to the research process to ensure that software can be evolved and reused by the next generation of scientists. To foster sustainability, scientists can highly benefit from education in principles and practices of software engineering, which can further be supported by established methods, tools, and technologies. This paper introduces SURESOFT, a twofold approach to address challenges in the development of research software regarding sustainable science that combines tools and infrastructure with education in the form of workshops and training. Furthermore, we report our experience of applying the SURESOFT approach to five software projects from different fields and discuss challenges, such as common bad practices and applicability in diverse scenarios