2,272 research outputs found
Women’s experiences of over-the-counter and prescription medication during pregnancy in the UK: findings from survey free-text responses and narrative interviews
OBJECTIVES: To explore women's experiences of over-the-counter and prescription medication advice and use during pregnancy. DESIGN: A study design consisting of an online survey and nested in-depth interviews with a subsample of participants. We analysed data from survey free-text responses and in-depth interviews using thematic analysis. Quantitative survey data is published elsewhere.The UK. PARTICIPANTS: Women were eligible if living in the UK, aged 16-45 years, were pregnant or had been pregnant in the last 5 years regardless of pregnancy outcome. A total of 7090 women completed the survey, and 34 women who collectively had experienced 68 pregnancies were subsequently interviewed. RESULTS: Medication prescribing and use during pregnancy was common. The prescribing, dispensing and taking of some advised medications were restricted through women's or prescribers' fear of fetal harm. Lack of adherence to national prescribing guidance, conflicting professional opinion and poor communication resulted in maternal anxiety, avoidable morbidity and women negotiating complex and distressing pathways to obtain recommended medications. In contrast, some women felt overmedicated and that pharmacological treatments were used without exploring other options first. CONCLUSION: Increased translation of national guidance into practice and greater personalisation of antenatal care are needed to improve the safety, efficacy and personalisation of prescribing in pregnancy
Spitzer Observations of Low Luminosity Isolated and Low Surface Brightness Galaxies
We examine the infrared properties of five low surface brightness galaxies
(LSBGs) and compare them with related but higher surface brightness galaxies,
using Spitzer Space Telescope images and spectra. All the LSBGs are detected in
the 3.6 and 4.5um bands, representing the stellar population. All but one are
detected at 5.8 and 8.0um, revealing emission from hot dust and aromatic
molecules, though many are faint or point-like at these wavelengths. Detections
of LSBGs at the far-infrared wavelengths, 24, 70, and 160um, are varied in
morphology and brightness, with only two detections at 160um, resulting in
highly varied spectral energy distributions. Consistent with previous
expectations for these galaxies, we find that detectable dust components exist
for only some LSBGs, with the strength of dust emission dependent on the
existence of bright star forming regions. However, the far-infrared emission
may be relatively weak compared with normal star-forming galaxies.Comment: 20 pages, 8 figures, accepted to Ap
Impact of D0-D0bar mixing on the experimental determination of gamma
Several methods have been devised to measure the weak phase gamma using
decays of the type B+- --> D K+-, where it is assumed that there is no mixing
in the D0-D0bar system. However, when using these methods to uncover new
physics, one must entertain the real possibility that the measurements are
affected by new physics effects in the D0-D0bar system. We show that even
values of x_D and/or y_D around 10^{-2} can have a significant impact in the
measurement of sin^2{gamma}. We discuss the errors incurred in neglecting this
effect, how the effect can be checked, and how to include it in the analysis.Comment: 18 pages, Latex with epsfig, 8 figure
Absolute physical calibration in the infrared
We determine an absolute calibration for the Multiband Imaging Photometer for Spitzer 24 μm band and recommend adjustments to the published calibrations for Two Micron All Sky Survey (2MASS), Infrared Array Camera (IRAC), and IRAS photometry to put them on the same scale. We show that consistent results are obtained by basing the calibration on either an average A0V star spectral energy distribution (SED), or by using the absolutely calibrated SED of the Sun in comparison with solar-type stellar photometry (the solar analog method). After the rejection of a small number of stars with anomalous SEDs (or bad measurements), upper limits of ~1.5% root mean square (rms) are placed on the intrinsic infrared (IR) SED variations in both A-dwarf and solar-type stars. These types of stars are therefore suitable as general-purpose standard stars in the IR. We provide absolutely calibrated SEDs for a standard zero magnitude A star and for the Sun to allow extending this work to any other IR photometric system. They allow the recommended calibration to be applied from 1 to 25 μm with an accuracy of ~2%, and with even higher accuracy at specific wavelengths such as 2.2, 10.6, and 24 μm, near which there are direct measurements. However, we confirm earlier indications that Vega does not behave as a typical A0V star between the visible and the IR, making it problematic as the defining star for photometric systems. The integration of measurements of the Sun with those of solar-type stars also provides an accurate estimate of the solar SED from 1 through 30 μm, which we show agrees with theoretical models
Measurements of Lifetimes and a Limit on the Lifetime Difference in the Neutral D-Meson System
Using the large hadroproduced charm sample collected in experiment E791 at
Fermilab, we report the first directly measured constraint on the decay-width
difference Delta Gamma for the mass eigenstates of the D0-D0bar system. We
obtain our result from lifetime measurements of the decays D0 --> K-pi+ and D0
--> K-K+, under the assumption of CP invariance, which implies that the CP
eigenstates and the mass eigenstates are the same. The lifetime of D0 --> K-K+
(the CP-even final state is \tau_KK = 0.410 +/- 0.011 +/- 0.006 ps, and the
lifetime of D0 --> K-pi+ (an equal mixture of CP-odd and CP-even final states
is tau_Kpi = 0.413 +/- 0.003 +/- 0.004 ps. The decay-width difference is Delta
Gamma = 2(Gamma_KK - Gamma_Kpi) = 0.04 +/- 0.14 +/- 0.05 ps^-1. We relate these
measurements to measurements of mixing in the neutral D-meson system.Comment: 8 pages + 3 figures + 2 table
A Search for Dark Matter Annihilation with the Whipple 10m Telescope
We present observations of the dwarf galaxies Draco and Ursa Minor, the local
group galaxies M32 and M33, and the globular cluster M15 conducted with the
Whipple 10m gamma-ray telescope to search for the gamma-ray signature of
self-annihilating weakly interacting massive particles (WIMPs) which may
constitute astrophysical dark matter (DM). We review the motivations for
selecting these sources based on their unique astrophysical environments and
report the results of the data analysis which produced upper limits on excess
rate of gamma rays for each source. We consider models for the DM distribution
in each source based on the available observational constraints and discuss
possible scenarios for the enhancement of the gamma-ray luminosity. Limits on
the thermally averaged product of the total self-annihilation cross section and
velocity of the WIMP, , are derived using conservative estimates for
the magnitude of the astrophysical contribution to the gamma-ray flux. Although
these limits do not constrain predictions from the currently favored
theoretical models of supersymmetry (SUSY), future observations with VERITAS
will probe a larger region of the WIMP parameter phase space, and
WIMP particle mass (m_\chi).Comment: 33 pages, 12 figures, accepted for publication in the Astrophysical
Journa
Far Infrared Source Counts at 70 and 160 microns in Spitzer Deep Surveys
We derive galaxy source counts at 70 and 160 microns using the Multiband
Imaging Photometer for Spitzer (MIPS) to map the Chandra Deep Field South
(CDFS) and other fields. At 70 microns, our observations extend upwards about 2
orders of magnitude in flux density from a threshold of 15 mJy, and at 160
microns they extend about an order of magnitude upward from 50 mJy. The counts
are consistent with previous observations on the bright end. Significant
evolution is detected at the faint end of the counts in both bands, by factors
of 2-3 over no-evolution models. This evolution agrees well with models that
indicate most ofthe faint galaxies lie at redshifts between 0.7 and 0.9. The
new Spitzer data already resolve about 23% of the Cosmic Far Infrared
Background at 70 microns and about 7% at 160 microns.Comment: Small modifications to match printed version. Models in Differential
Counts plots were changed. MIPS Source Counts are available at:
http://lully.as.arizona.edu/GTODeep/Counts/ . Accepted for Publication in
ApJS Special Issue on Spitze
New Debris Disks Around Nearby Main Sequence Stars: Impact on The Direct Detection of Planets
Using the MIPS instrument on the Spitzer telescope, we have searched for
infrared excesses around a sample of 82 stars, mostly F, G, and K main-sequence
field stars, along with a small number of nearby M stars. These stars were
selected for their suitability for future observations by a variety of
planet-finding techniques. These observations provide information on the
asteroidal and cometary material orbiting these stars - data that can be
correlated with any planets that may eventually be found. We have found
significant excess 70um emission toward 12 stars. Combined with an earlier
study, we find an overall 70um excess detection rate of % for mature
cool stars. Unlike the trend for planets to be found preferentially toward
stars with high metallicity, the incidence of debris disks is uncorrelated with
metallicity. By newly identifying 4 of these stars as having weak 24um excesses
(fluxes 10% above the stellar photosphere), we confirm a trend found in
earlier studies wherein a weak 24um excess is associated with a strong 70um
excess. Interestingly, we find no evidence for debris disks around 23 stars
cooler than K1, a result that is bolstered by a lack of excess around any of
the 38 K1-M6 stars in 2 companion surveys. One motivation for this study is the
fact that strong zodiacal emission can make it hard or impossible to detect
planets directly with future observatories like the {\it Terrestrial Planet
Finder (TPF)}. The observations reported here exclude a few stars with very
high levels of emission, 1,000 times the emission of our zodiacal cloud,
from direct planet searches. For the remainder of the sample, we set relatively
high limits on dust emission from asteroid belt counterparts
Debris disks around Sun-like stars
We have observed nearly 200 FGK stars at 24 and 70 microns with the Spitzer
Space Telescope. We identify excess infrared emission, including a number of
cases where the observed flux is more than 10 times brighter than the predicted
photospheric flux, and interpret these signatures as evidence of debris disks
in those systems. We combine this sample of FGK stars with similar published
results to produce a sample of more than 350 main sequence AFGKM stars. The
incidence of debris disks is 4.2% (+2.0/-1.1) at 24 microns for a sample of 213
Sun-like (FG) stars and 16.4% (+2.8/-2.9) at 70 microns for 225 Sun-like (FG)
stars. We find that the excess rates for A, F, G, and K stars are statistically
indistinguishable, but with a suggestion of decreasing excess rate toward the
later spectral types; this may be an age effect. The lack of strong trend among
FGK stars of comparable ages is surprising, given the factor of 50 change in
stellar luminosity across this spectral range. We also find that the incidence
of debris disks declines very slowly beyond ages of 1 billion years.Comment: ApJ, in pres
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